Svitlana Gorobets

Effect of a magnetic field on the etching of steel in nitric acid solutions

The effect of a static magnetic field on the chemical etching of steel in nitric acid solutions was studied. It was demonstrated that the field substantially promotes the process of etching because of the magnetohydrodynamic intensification of mass transfer, the limiting stage of steel dissolution in nitric acid solutions.

Magnetic dipole interaction of endogenous magnetic nanoparticles with magnetoliposomes for targeted drug delivery

Dynamics of magnetoliposomes binding to the tumor cells and the efficiency of their recognition for targeted drug delivery is largely determined by physical interaction. In this paper we assess the strength of magnetic dipole interaction that occurs between endogenous magnetic nanoparticles in tumor cells and exogenous magnetic nanoparticles as a component of magnetoliposomes, and compare it with the forces of specific binding of the antigen-antibody complex. To assess the strength of magnetic dipole interaction the model of chains of identical particles was used, and an order of magnitude, 10−9 N, was obtained. Thus, the indicated force has an order of magnitude close to the forces of specific binding, and even more. The force of magnetic dipole interaction between a magnetically marked dosage form and tumor cells is virtually the additional specific binding force — “passive targeting” for targeted drug delivery in consequence of the fact that tumor cells tend to contain the number of biogenic nanoparticles of magnetite (Fe3O4) by an order of magnitude greater than normal.

Influence of magnetostatic fields of a ferromagnetic substrate on the electrodeposition of nickel dendrites

The influence of the magnetic state of a ferromagnetic wire substrate on the morphology of deposited nickel obtained by electrolysis has been studied. It has been demonstrated using statistical analysis that in the course of nickel electrodeposition without external magnetic field the dimensional characteristics of the arising dendritic structures are affected significantly by the residual magnetization of the substrate. When in the course of Ni electrodeposition even a weak dc magnetic field is applied perpendicularly to the wire axis, nearly identical structures are formed; that is, the system “forgets” its previous magnetic state. The magnetic properties of the substrate were visualized using powder patterns.

Stationary flows of liquid in the vicinity of the small ferromagnetic particles in permanent homogeneous magnetic fields

The phenomenon of stationary flow origin is investigated in solutions of electrolytes near small ferromagnetic particles, having various shapes, under influence of an external permanent homogeneous magnetic field. Dependence of velocity of the flows on the size of needle and ball shaped ferromagnetic particles is represented in the paper.

Роль патогенних мікроорганізмів у накопиченні біогенних магнітних наночастинок у тканинах легень

Purpose: In this paper the role of pathogenic microorganisms in the accumulation of biogenic magnetic nanoparticles in lung tissues is examined. The main purpose of the present research is to prove that biogenic magnetic nanoparticles can be accumulated in lung tissues because of the pathogenic microorganisms during lung disease. Methods: Pairwise and multiple alignment of amino acid sequences, electron paramagnetic resonance. Results: The producers of biogenic magnetic nanoparticles were found among pathogenic microorganisms that cause lung disease. Biogenic magnetic nanoparticles can be accumulated in lung tissues because of these pathogenic microorganisms during relevant lung diseases. The presence of biogenic magnetic nanoparticles in lung tissues was proved using the electron paramagnetic resonance spectra analysis. Discussion: The results of the present research can be used to understand the possible reasons of toxic and allergic effects and even corking of vessels during uncontrolled accumulation of magnetic nanoparticles in different organs and tissues because of their magnetic dipole-dipole interaction with biogenic magnetic nanoparticles on cell membranes and to prevent it.

Physiological origin of biogenic magnetic nanoparticles in health and disease: from bacteria to humans

The discovery of biogenic magnetic nanoparticles (BMNPs) in the human brain gives a strong impulse to study and understand their origin. Although knowledge of the subject is increasing continuously, much remains to be done for further development to help our society fight a number of pathologies related to BMNPs. This review provides an insight into the puzzle of the physiological origin of BMNPs in organisms of all three domains of life: prokaryotes, archaea, and eukaryotes, including humans. Predictions based on comparative genomic studies are presented along with experimental data obtained by physical methods. State-of-the-art understanding of the genetic control of biomineralization of BMNPs and their properties are discussed in detail. We present data on the differences in BMNP levels in health and disease (cancer, neurodegenerative disorders, and atherosclerosis), and discuss the existing hypotheses on the biological functions of BMNPs, with special attention paid to the role of the ferritin core and apoferritin.

ANALYSIS OF EFFECTIVNESS OF MAGNETICALLY LABELED BIOSORBENT OBTAINED THROUGH THE MECHANICAL AND MAGNETOHYDRODYNAMIC STIRRING

The efficiency of Cu 2+ ion extraction of magnetically labeled biosorbent based on yeast Sacharomyces cerevisiae obtained by magnetohydrodynamic stirring in combined magnetic and electric fields has been determined. The effect of different concentration of magnetic nanoparticles and yeast cells on the magnetic susceptibility was determined. Optimal magnetite content is 1 %, as such biosorbent has a maximum magnetic susceptibility and the best stability. The higher sorption capacity is observed for magnetically labeled biosorbent obtained through the magnetohydrodynamic stirring in the combined magnetic and electric field with concentration of magnetite 1 %. The process of active and passive biosorption shows that part of the magnetite nanoparticles has been attached to the surface of biosorbent. This indicates that both passive and active sorption takes place in the process of interaction of yeast cells and magnetite nanoparticles.

Фрактальна розмірність резистентних та чутливих до доксорубіцину клітин раку молочної залози, експонованих у магнітному полі

У роботі досліджується фрактальна розмірність резистентних та чутливих до дії доксорубіцину клітин раку молочної залози, експонованих у магнітному полі. Виявлено, що резистентні та чутливі до дії доксорубіцину клітини раку молочної залози лінії MCF мають різне значення фрактальної розмірності. Таким чином, головна мета цього дослідження полягає в перевірці можливості використання фрактальної розмірності як маркеру для визначення чутливості до дії доксорубіцину клітин раку молочної залози лінії MCF, експонованих у магнітному полі.

Magnetic force microscopy of atherosclerotic plaque.

In this work by methods of scanning probe microscopy, namely by atomic force microscopy and magnetic force microscopy the fragments of atherosclerotic plaque section of different nature were investigated. The fragments of atherosclerotic vessels with elements of immature plaque were taken during the coiled artery bypass surgery by alloprosthesis. As the result of investigation we found magnetically ordered phase of endogenous origin in the fragment of solid plaque of mixed structure. This phase is presents biogenic magnetic nanoparticles and their clusters with average size characteristic of 200-400 nm.