Sweety Singhal

An efficient aerobic oxidative cyanation of tertiary amines with sodium cyanide using vanadium based systems as catalysts

The first report on the use of vanadium-based catalysts for oxidative cyanation of tertiary amines with molecular oxygen in the presence of sodium cyanide and acetic acid to afford the corresponding alpha-aminonitriles in good to excellent yields is described.

PEG-assisted solvent and catalyst free synthesis of 3,4-dihydropyrimidinones under mild reaction conditions

PEG-assisted solvent and catalyst free synthesis of 3,4-dihydropyrimidinones under mild and neutral reaction conditions is described.

Mild Organic Ammonium Tribromide–Mediated Regioselective Ring Opening of Epoxides with Alcohols, Water, Acetic Anhydride, and Amines Under Solvent-Free Reaction Conditions

Abstract Organic ammonium tribromide (OATB), N-methylpyrrolidine-2-one hydrotribromide (MPHT) was found to be an efficient catalyst for the regioselective ring opening of epoxides with various nucleophiles under solvent free conditions. This procedure occurs under neutral and mild reaction conditions with out adding any additive and afforded high yields of products.

Synthesis of 3,4-dihydropyrimidinones in the presence of water under solvent free conditions using conventional heating, microwave irradiation/ultrasound

Abstract An efficient, simple, and environmentally clean synthesis of 3,4-dihydropyrimidinones in excellent yields in the presence of water without additional solvent/acid catalyst under conventional heating, microwave irradiation/ultrasound is reported.

MoO3/Al2O3 : AN EFFICIENT AND REUSABLE HETEROGENEOUS CATALYST FOR SOLVENT-FREE SYNTHESIS OF COUMARINS VIA PECHMANN CONDENSATION

16 wt % alumina supported MoO 3 has been found to be an efficient catalyst for the synthesis of various substituted coumarins via Pechmann condensation. This method offers several advantages like high yields, facile recovery and reusability of the catalyst without loss in activity, nearly neutral and solvent free condition.

Stereoselective Synthesis of endo-7-Halo-3-Oxo-2-Azabicyclo[4.1.0]Heptanes by Reductive Hydrodehalogenation of gem-Dihalocyclopropanes

The reduction of 7-gem-dihalo-3-oxo-2-azabicyclo[4.1.0]heptanes with metallic zinc yielded stereoselective synthesis of novel heterocyclic endo-7-halo-3-oxo-2-azabicyclo[4.1.0]heptanes in good to high yields without any evidence for the formation of corresponding exo-isomers. The prepared heterocyclic compounds were characterized by various techniques and their stereochemistry was established on the basis of the values of the coupling constants for H-1, H-5, H-6 and H-7 by recording homonuclear spin-spin decoupled H NMR spectra. The developed protocol has many advantages such as simple reaction conditions, lower cost, high yields, and selective synthesis of novel heterocyclic cyclopropyl compounds present in a large number of biologically active natural products and pharmaceuticals compounds.