Sylvia M. J. Hains

Effects of Experience on Fetal Voice Recognition

The ability of human fetuses to recognize their own mothers voice was examined. Sixty term fetuses were assigned to one of two conditions during which they were exposed to a tape recording of their mother or a female stranger reading a passage. Voice stimuli were delivered through a loudspeaker held approximately 10 cm above the maternal abdomen and played at an average of 95 dB SPL. Each condition consisted of three 2-min periods: no stimulus, voice (mother or stranger), and no stimulus. Fetal heart rate increased in response to the mothers voice and decreased in response to the strangers; both responses were sustained for 4 min. The finding of differential behavior in response to a familiar versus a novel voice provides evidence that experience influences fetal voice processing. It supports an epigenetic model of speech perception, presuming an interaction between genetic expression of neural development and species-specific experience.

Fetal sensitivity to properties of maternal speech and language

Fetal speech and language abilities were examined in 104 low-risk fetuses at 33-41 weeks gestational age using a familiarization/novelty paradigm. Fetuses were familiarized with a tape recording of either their mother or a female stranger reading the same passage and subsequently presented with a novel speaker or language: Studies (1) & (2) the alternate voice, (3) the fathers voice, and (4) a female stranger speaking in native English or a foreign language (Mandarin); heart rate was recorded continuously. Data analyses revealed a novelty response to the mothers voice and a novel foreign language. An offset response was observed following termination of the fathers and a female strangers voice. These findings provide evidence of fetal attention, memory, and learning of voices and language, indicating that newborn speech/language abilities have their origins before birth. They suggest that neural networks sensitive to properties of the mothers voice and native-language speech are being formed.

Social Competence and Person-Object Differentiation: An Analysis of the Still-Face Effect.

The communicative abilities of infants, revealed in the still-face (SF) procedure, were examined in 2 studies comparing behavior toward people and «interactive» objects. In Experiment 1, thirty-two 3- and 6-month-olds were presented with an object and a person (mother or female stranger). The SF effect was produced only by mothers and strangers. Positive affect clearly established person-object differentiation; infants smiled at people but rarely at the object. In Experiment 2, twelve 3-month-olds were presented with 4 stimuli: a female stranger and 3 objects with features varying in similarity to an abstract, smiling face. Again, infants reseerved their smiles for the person

Individual differences in word recognition latency

Previous studies of the effects of word characteristics on word recognition have used orthogonal combinations of word variables and have failed to consider individual differences. The present study examined word naming (Experiment 1) and lexical decision (Experiment 2) tasks using an unrestricted set of words and a correlational analysis. Individual differences were considered using a measure of the subjects’ knowledge of the English vocabulary. The results of Experiment 1 indicated that log (RT) for word naming is affected by word length, word frequency, and the number of syllables in the word; the results of Experiment 2 confirmed the effects of length and frequency but also showed that log (RT) is a function of the age at which the word is introduced to a child’s reading vocabulary. Subjects with a high vocabulary score were more rapid in Experiment 1 but were slower in Experiment 2, compared to subjects with a low vocabulary score. More importantly, high-vocabulary subjects, in both studies, were less affected by word length than the low-vocabulary subjects. The results suggest that subjects do differ in their reading strategy and that word length and word frequency may affect different stages in the word recognition process.

Swaddling after heel lance : Age-specific effects on behavioral recovery in preterm infants

We examined responses of preterm infants to swaddling after a heel lance. Fifteen preterm infants from two postconceptional age (PCA) groups (Group 1: n = 7, PCA < 31 wk; Group 2: n = 8, PCA ≥ 31 wk) were observed for 30 minutes during blood sampling followed by routine care; blood sampling followed by swaddling; and no blood sampling and routine care. In both groups, blood sampling resulted in concurrent increases in heart rate and state of arousal, in negative facial displays, and in reductions in blood oxygen-saturation. After the blood was drawn, infants less than 31 weeks PCA exhibited an immediate and spontaneous return to behavioral patterns similar to those observed during the no-blood-sample condition, regardless of treatment condition. Infants 31 weeks PCA or older exhibited protracted behavioral disturbance that was significantly reduced by the use of swaddling. We discuss the significance of these findings.

Infant Sensitivity to Perturbations in Adult Facial, Vocal, Tactile, and Contingent Stimulation During Face-to-Face Interactions

Results from studies using the Still-Face procedure showed that 3–6-month-olds respond to dynamic faces in face-to-face interactions, but not to changes in adult voice, touch or contingency in both live and televised interactions. Infant visual attention distinguished between normal and still-face periods, while smiling distinguished people from objects, and upright from inverted faces. Results from other paradigms showed that the adult voice and touch can affect infant responding and infants are sensitive to contingency. A complete description of infant’s perceptual capacities requires the use of multiple response measures and consideration of the experimental demands.

Maturation of human fetal responses to airborne sound in low- and high-risk fetuses

The purpose of the study was to characterize the onset and maturation of airborne sound-elicited responses in low- and high-risk preterm fetuses. In Study 1, a total of 91 low-risk fetuses at 27, 30, 33, and 36 weeks GA received three sound trials at 90, 100, 105 and 110 dB and three no-stimulus control trials. The onset of cardiac acceleration and body movement responses occurred at 30 weeks GA. Maturation of the cardiac response was observed with a decrease in threshold from 105-110 dB at 33 weeks GA to 100-105 dB at 36 weeks GA. In Study 2, the procedure was similar except that the 43 high-risk fetuses at 27, 30 and 33 weeks GA did not receive sounds at 90 dB. For the high-risk fetuses, the onset of cardiac and motor responses also occurred at 30 weeks GA. At 33 weeks GA, those high-risk fetuses subsequently born at term showed an increased magnitude of the cardiac acceleration response compared to low-risk fetuses. The results indicate that both low- and high-risk fetuses begin responding to sounds at the same gestational age. Differential responses observed over gestation in the high-risk group most likely indicate differential functional development of the auditory-response system.

Effects of Endotracheal Tube Suctioning on Arterial Oxygen Tension and Heart Rate Variability

The purpose of this study was to examine the autonomic mechanisms underlying changes in heart rate (HR) and systolic blood pressure (SBP) responses to endotracheal tube (ETT) suctioning and to compare the open versus closed methods of ETT suctioning on these measures and on arterial oxygen tension. Eighteen orally intubated participants, 33 to 82 years of age (M = 60 years), were randomized for the order of suctioning method. Arterial oxygen tension (PaO 2 ) was measured before suctioning and 30 s and 5 min following suctioning. Beat-to-beat HR and arterial blood pressure data were collected for 10-min periods before and after suctioning. HR and SBP measures were analyzed before suctioning and 1 min and 5 min following suctioning. Although there were no significant effects of ETT suctioning on the autonomic mechanisms of HR modulation and no significant differences between the two methods of suctioning, ETT suctioning resulted in an increase in HR, SBP, and PaO 2 . However, there was a decrease in the parasympathetic nervous system indicator of HR variability (HRV) following open suctioning. All patients in this study maintained a PaO 2 level 80 mm Hg, which may account for our lack of significant autonomic changes. This suggests that hyperoxygenation with 100% oxygen for a minimum of 1 min (or 20 breaths), as delivered by preoxygenation modes available on most microprocessor ventilators, should be the method of choice for all hyperoxygenation procedures to avoid a decrease in PaO 2 following suctioning.

The effects of exercise conditioning in normal and overweight pregnant women on blood pressure and heart rate variability.

Pre-pregnancy obesity is a risk factor for preeclampsia, gestational diabetes, and hypertension. Regular exercise during pregnancy has been shown to decrease the risk of these obstetrical complications. The purpose of this prospective study was to measure the effects of an exercise program in normal-weight and overweight/obese pregnant women on blood pressure (BP) and cardiac autonomic function, determined by heart rate variability (HRV) and baroreflex sensitivity (BRS). Twenty-two sedentary pregnant women, recruited at 20 weeks gestational age (GA), were grouped as normal weight or overweight/obese. They were systematically assigned to an exercise (walking) group or control (nonwalking) group after the first participants were randomly assigned. Women in the walking groups participated in a 16-week, low-intensity walking program. BP, HRV, and BRS were measured at rest and during exercise at the beginning (20 weeks GA) and end (36 weeks GA) of the walking program. Results indicated that women in the control groups (especially overweight women) showed changes in BP, HRV, and BRS over pregnancy that were not seen in the walking group. Overweight women in the control group increased resting systolic BP by 10 mmHg and diastolic BP by 7 mmHg. HRV declined in the control group but not in the walking group. A reduction in BRS and R-R interval at rest was found in all groups except the walking normal-weight group. The results suggest that an exercise program could attenuate the increase in BP and the loss of parasympathetic tone associated with pregnancy, especially in overweight women.

Fetal Development: Voice Processing in Normotensive and Hypertensive Pregnancies:

Recent observation of maternal voice recognition provides evidence of rudimentary memory and learning in healthy term fetuses. However, such higher order auditory processing has not been examined in the presence of maternal hypertension, which is associated with reduced and/or impaired uteroplacental blood flow. In this study, voice processing was examined in 40 fetuses (gestational ages of 33 to 41 weeks) of hypertensive and normotensive women. Fetuses received 2 min of no sound, 2 min of a tape-recorded story read by their mothers or by a female stranger, and 2 min of no sound while fetal heart rate was recorded. Results demonstrated that fetuses in the normotensive group had heart rate accelerations during the playing of their mothers voice, whereas the response occurred in the hypertensive group following maternal voice offset. Across all fetuses, a greater fetal heart rate change was observed when the amniotic fluid index was above compared to below the median (i.e., 150 mm), indicating that amniotic fluid volume may be an independent moderator of fetal auditory sensitivity. It was concluded that differential fetal responding to the mothers voice in pregnancies complicated by maternal hypertension may reflect functional elevation of sensorineural threshold or a delay in auditory system maturation, signifying functional differences during fetal life or subtle differences in the development of the central nervous system.