Szilágyi T

Macrophage disappearance reaction induced by lymphokines

Macrophage disappearance reaction was induced in normal (non-sensitized) guinea pigs by human lymphokines deriving from Con A-stimulated lymphocytes, by ellagic acid (an activator of intrinsic coagulation) and by thromboplastin (an activator of extrinisic coagulation). The results are discussed from the aspect of the pathomechanism of macrophage disappearance reaction.

Effects of lymphokines on fibrinolysis and kinin generation in human plasma.

Supernatants from Con-A-stimulated human lymphocytes containing leukocyte migration inhibitory factor, skin reactive factor and procoagulant activities were tested for their effect on fibrinolysis and kinin generation. The supernatants of stimulated lymphocytes activated the fibrinolysis and generated kinin in human plasma. These results are discussed from the aspect of cell-mediated (type IV) immune inflammation.

Local effect of single stranded polyadenylic acid on passive cutaneous anaphylaxis in mice.

Single stranded polyadenylic acid (Poly A) administered locally inhibited passive cutaneous anaphylaxis in mice. In experiments performed by equilibrium dialysis Poly A was able to bind histamine. The association constant of the reaction was determined,Kα=1.3±0.2×105 l/M. One Poly A molecule can bind maximally two molecules of histamine dichloride. Poly A inhibited the antigen-induced release of histamine from the peritoneal rat mast cells when it was given together with sensitizing antibodies.

Effect of the ganglionic blocking agent: 1:2:2:6:6-pentamethylpiperidine on different types of allergic skin reactions

We examined the effect of ganglionic blocking agent 1:2:2:6:6-pentamethylpiperidine (Synapleg®, EGyT) on the allergic skin inflammations of immediate (passive cutaneous anaphylaxis, inverse passive Arthus) and delayed (dinitrochlorobenzene, Jones-Mote) hypersensitivity. It was found that the ganglionic blocking agent inhibits the inflammations of immediate hypersensitivity to a greater extent than the delayed ones.