T. Barankay

Decrease of arylsulfatase A activity in plasma in hemorrhagic shock

Bei 52 Hunden wurde in einem 90 Minuten dauernden Blutungs-Schock mit einem Blutdruck von 40 mm Hg eine 30%ige Verminderung der Aktivität der Arylsulfatase A im Plasma beobachtet.

Time course of metabolite and enzyme changes in hypoxic conditions.

Tissue hypoxia of shock is often characterized by metabolites of anaerobic glycolysis released into the blood plasma auch as lactic and pyruvic acids and by the so-called “excess lactate” of Huckabee. (Huckabee 1958; Rosenberg et al., 1961; Peretz et al., 1965). Release of lysosomal and cytoplasmic enzymes into the circulation also occurs in hemorrhagic shock. We have shown earlier that their plasma level correlates well with the severity of shock (Gergely et al., 1970; Barankay and Petri 1969). According to the investigations of Schmidt during hypoxic damage of isolated, perfused organs a significant release of enzymes and metabolites takes place (Schimdt et al., 1966). These substances appear in the perfusate after the lapse of a certain period of time depending on their intracellular localization, binding, etc.

Effect of Vasoconstrictors on Lymph Oxygen Tension in Normo- and Hypovolemia

The effects of various vasoconstrictor agents at the microcirculatory level have been debated for many years. As these agents are still rather widely used in the therapy of various forms of shock, It seems important to acquire information about their effect on tissue oxygenation. Tissue hypoxia has a key role in the pathogenesis of shock, there are, however, few data available on the level of tissue oxygen tension because of methodological difficulties.

Effect of Corticosteroid Treatment on Lymph Oxygen Tension in Hemorrhagic Shock

Oxygen tension of thoracic duct lymph was measured continuously in dogs subjected to hemorrhagic shock. Compared to untreated controls, the group given during the development of the shock a single lar