T.K. Bharathi

DABCO catalyzed dimerization of α,β-unsaturated ketones and nitriles

Abstract α,β-Unsaturated ketones dimerize in the presence of catalytic amount of 1,4-diazabicyclo[2.2.2]octane(DABCO) to produce the corresponding 2-methylene-1,5-diketones in good yields. Acrylonitrile provides the corresponding dimerized product.

DABCO catalyzed coupling of α-keto esters with acrylonitrile and methyl acrylate

Abstract Coupling of acrylonitrile to α-keto esters is readily achieved using 1,4-diazabicyclo[2.2.2]-octane(DABCO) as a catalyst to produce 2-[1-carboalkoxy-1-hydroxyalkyl]acrylonitriles in good yields. Similar reaction with methyl acrylate produces the corresponding 2-substituted acrylates.

Enantioselective synthesis of α- and β-hydroxy acids using trans-2-phenylcyclohexan-1-ol-as chiral auxiliary

trans-2-Phenylcyclohexanol has been used as a chiral auxiliary for the preparation of α- and β-hydroxy acids in 85–100% and 11–89% enantiomeric purities respectively.

Convenient enantioselective hydrolysis of racemic trans-1-acetoxy-2-aryloxycyclohexanes by crude pig liver acetone powder (PLAP)

Crude pig liver acetone powder (PLAP) hydrolyzes trans-1-acetoxy-2 aryloxycyclohexanes enantio-selectively to produce the corresponding alcohols in high optical purities.

A General Synthesis of α-Methylene-β-Hydroxyalkanones

Abstract Several α-methylene-β-hydroxyalkanones have been prepared by 1,4-diazabicyclo[2.2.2]-octane(DABCO) catalyzed coupling of α, β-unsaturated ketones with aldehydes.

trans-2-Phenoxycyclohexan-1-OL as New Chiral Auxiliary: Synthesis of Chiral α-Hydroxy Acids

Abstract (1R,2R)-2-Phenoxycyclohexan-1-ol is used as a chiral auxiliary for the preparation of α-hydroxy acids in high optical purities.

Towards Chiral Reformatsky Reagents

Abstract Chiral β-hydroxyacids are obtained via the Reformatsky reaction of lactic acid derivatives with carbonyl compounds in 11–100% optical purities.