T. K. Lau

Trends in maternal obesity and associated risks of adverse pregnancy outcomes in a population of Chinese women.

Objective  To assess the effect of increasing body mass index (BMI) on pregnancy outcome in a population of Chinese women.

Non-invasive prenatal testing for fetal chromosomal abnormalities by low-coverage whole-genome sequencing of maternal plasma DNA: review of 1982 consecutive cases in a single center

To review the performance of non‐invasive prenatal testing (NIPT) by low‐coverage whole‐genome sequencing of maternal plasma DNA at a single center.

Effect of twin-to-twin delivery interval on umbilical cord blood gas in the second twins

Objective To examine the effect of twin‐to‐twin delivery interval on the umbilical cord blood gas status of the second twin following vaginal delivery.

Predictors of successful external cephalic version at term: a prospective study

Objective To investigate clinical and ultrasonographic predictors of outcome of external cephalic version at term.

Fetal aneuploidy screening by maternal plasma DNA sequencing: ‘False positive’ due to confined placental mosaicism

INTRODUCTION Non-invasive prenatal testing (NIPT) of fetal Down syndrome by maternal plasma DNA sequencing have been proven to be a highly efficient screening test, with both sensitivity and specificity of over 99%. This new screening test has been recently put into clinical service used either as a primary or secondary screening test for aneuploidy. There is increasing evidence that this new technology is also highly efficient in the screening of aneuploidies involving other chromosomes. Research so far has suggested that these cell-free DNAs are from the placenta. Therefore, an abnormal NIPT result could be due to conditions other than fetal trisomy. We report here a case in which the NIPT was positive for trisomy 22 because of confined placental mosaicism.

Fetal intra‐abdominal umbilical vein varix: what is the clinical significance?

To assess the clinical significance of fetal intra‐abdominal umbilical vein (FIUV) varix.

Prediction of birth weight by fetal crown-rump length and maternal serum levels of pregnancy-associated plasma protein-A in the first trimester

To determine whether the first trimester crown–rump length (CRL), maternal serum levels of pregnancy‐associated plasma protein A (PAPP‐A) and free beta‐human chorionic gonadotropin (fβ‐hCG) are independent predictors of birth weight.

Which ultrasound or biochemical markers are independent predictors of small-for-gestational age?

To investigate which ultrasound or biochemical markers in both the first and the second trimesters are the best predictors for fetal growth and small‐for‐gestational age (SGA).

The impact of human copy number variation on a new era of genetic testing

Please cite this paper as: Choy K, Setlur S, Lee C, Lau T. The impact of human copy number variation on a new era of genetic testing. BJOG 2010;117:391–397.

Customizing fetal biometric charts

To study the effects of maternal and pregnancy characteristics on fetal biometric size using longitudinal ultrasound measurements and to construct customized models for fetal biometric size charts.