T Kirchner

Revealing the Role of Anchoring Groups in the Electrical Conduction Through Single‐Molecule Junctions

A combined experimental and theoretical study is presented revealing the influence of metal-molecule coupling on electronic transport through single-molecule junctions. Transport experiments through tolane molecules attached to gold electrodes via thiol, nitro, and cyano anchoring groups are performed. By fitting the experimental current-voltage characteristics to a single-level tunneling model, we extract both the position of the molecular orbital closest to the Fermi energy and the strength of the metal-molecule coupling. The values found for these parameters are rationalized with the help of density-functional-theory-based transport calculations. In particular, these calculations show that the anchoring groups determine the junction conductance by controlling not only the strength of the coupling to the metal but also the position of the relevant molecular energy levels.

Constrained image-based B0 shimming accounting for “local minimum traps” in the optimization and field inhomogeneities outside the region of interest

To improve B0 shimming for applications in high‐ and ultrahigh‐field magnetic resonance imaging and magnetic resonance spectroscopy.

Reduction of voxel bleeding in highly accelerated parallel 1H MRSI by direct control of the spatial response function

To substantially improve spatial localization in magnetic resonance spectroscopic imaging (MRSI) accelerated by parallel imaging. This is important in order to make MRSI more reliable as a tool for clinical applications.

Mechanisms of SNR and line shape improvement by B0 correction in overdiscrete MRSI reconstruction

Inhomogeneities of the main magnetic field cause line broadening and location‐dependent frequency shifts in brain MRSI. These are often visible despite advanced B0 shimming. The purpose of this work is to propose an advanced B0 correction method that can easily be applied during postprocessing.

Over-discretized SENSE reconstruction and B 0 correction for accelerated non-lipid-suppressed 1H FID MRSI of the human brain at 9.4 T

The aim of this work was to use post‐processing methods to improve the data quality of metabolite maps acquired on the human brain at 9.4 T with accelerated acquisition schemes. This was accomplished by combining an improved sensitivity encoding (SENSE) reconstruction with a B0 correction of spatially over‐discretized magnetic resonance spectroscopic imaging (MRSI) data.

Overdiscrete Reconstruction for Highly Accelerated Parallel 1H MRSI at 7T with Efficient Control of Voxel Bleeding

not available 409 Tumorous lesions I. Nöbauer-Huhmann Radiology, Medical University of Vienna, Vienna/AUSTRIA Learning Objectives: Upon completion of this session, participants should be able to 1.) Recognize characteristic radiologic features of solitary spine lesions 2.) determine the most likely diagnosis 3.) recommend an adequate imaging algorithm Body: Primary bone tumors of the spine are rare, compared with osseous metastases or manifestations of myeloproliferative disease. The radiologist coming across a solitary osseous lesion of the spine should be able to recognize its typical imaging characteristics (including tumor matrix, margin and transition zone, local extension, cortical destruction, periosteal reaction, soft tissue involvement, potential multifocal manifestation, and more specific features, as fluid-fluid-levels, coarse vertical trabeculation, or a nidus). Also taking into account general considerations, as the age of the patient, his symptoms and the location of the lesion (this includes the vertebral level, as well as the site within the vertebra itself) can help in defining the most likely diagnosis. Benign entities include enostosis, hemangioma (which may be locally aggressive), osteoid osteoma and osteoblastoma, osteochondroma, locally aggressive tumors as the giant cell tumour, and tumor like lesions as the aneurysmatic bone cyst. Among the malignant lesions are osteosarcomas, chondrosarcomas, chordomas, and ewing sarcomas. The radiologist should be aware of the diagnostic value of the imaging modalities, including projection radiography, CT, MRI, PET/CT, and other methods. He may also, if necessary, help in defining an optimal biopsy site or perform an image guided biopsy himself. He should be able to initiate an adequate imaging algorithm, and know when to refer the patient to a tumor center. References: Murphey MD, Andrews CL, Flemming DJ, et al. Primary tumors of the spine: radiologic-pathologic correlation. RadioGraphics 1996;16(5):1131–1158. Vidal JA, Murphey MD. Primary Tumors of the Osseous Spine. Magn Reson Imaging Clin N Am 2007; 15: 239–255. Rodallec MH, Feydy A, Larousserie F, et al. Diagnostic Imaging of Solitary Tumors of the Spine: What to Do and Say. RadioGraphics 2008; 28:1019–1041. ACR Appropriateness Criteria® primary bone tumors () Ultra-short echo time: techniques and insights Saturday, October 6 ESMRMB 2012 314 79 Scientific Session Preclinical Studies & Basic Science 16:10 17:40 Room 5A Ultra-short echo time: techniques and