T. Pasciuto

Ovarian masses with papillary projections diagnosed and removed during pregnancy: ultrasound features and histological diagnosis

To elucidate the ultrasound features that can discriminate between benign and malignant ovarian cysts with papillary projections but no other solid component in pregnant women.

Imaging in gynecological disease (11): clinical and ultrasound features of mucinous ovarian tumors

To describe the clinical and ultrasound findings in patients with mucinous ovarian tumors.

Imaging in gynecological disease (12): clinical and ultrasound features of invasive and non‐invasive malignant serous ovarian tumors

To describe clinical and ultrasound features of different subclasses of malignant serous ovarian tumors according to the World Health Organization 2014 classification.

PRospective Imaging of CErvical cancer and neoadjuvant treatment (PRICE) study: role of ultrasound to predict partial response in locally advanced cervical cancer patients undergoing chemoradiation and radical surgery

Chemoradiation‐based neoadjuvant treatment followed by radical surgery is an alternative therapeutic strategy for locally advanced cervical cancer (LACC), but ultrasound variables used to predict partial response to neoadjuvant treatment are not well defined. Our goal was to analyze prospectively the potential role of transvaginal ultrasound in early prediction of partial pathological response, assessed in terms of residual disease at histology, in a large, single‐institution series of LACC patients triaged to neoadjuvant treatment followed by radical surgery.

The PRICE study: The role of conventional and diffusion-weighted magnetic resonance imaging in assessment of locally advanced cervical cancer patients administered by chemoradiation followed by radical surgery

ObjectivesTo analyse the role of DW-MRI in early prediction of pathologically-assessed residual disease in locally-advanced cervical cancer (LACC) treated with neoadjuvant chemoradiotherapy followed by radical surgery.MethodsBetween October 2010–June 2014, 108 women with histologically-proven cervical cancer were screened; 88 were included in this study. Tumour volume (TV) and ADCmean were measured before (baseline-MRI) and after 2 weeks of chemoradiotherapy (early-MRI). According to histopathology, treatment response was classified as complete (CR) or partial (PR). Comparisons were made with Mann-Whitney, Wilcoxon and χ2 tests. ROC curves were generated for statistically significant parameters on univariate analysis.ResultsCR and PR were documented in 40 and 48 patients. At baseline-MRI, TV did not differ between groups. At early-MRI, TV was higher in PR than in CR (p=0.001). ΔTV reduction after treatment was lower in PR than in CR (63.6% vs. 81.1%; p=0.001). At baseline-MRI and early-MRI, ADCmean did not differ between PR and CR. ROC curve showed best cut-off for predicting pathological PR was ΔTV reduction of 73% with sensitivity, specificity, accuracy, NPV, PPV of 73%, 72.5%, 72.7%, 76%, 69%.ConclusionsTV evaluated before and early after treatment could predict pathological response in LACC. ADCmean did not correlate with treatment outcome.Key Points• Early-MRI tumour volume assessment could predict pathological response to nCRT in LACC.• Best cut-off for predicting pathological PR was ΔTV reduction of 73 %.• Early-MRI ADCmeanmeasurements did not correlate with treatment outcome.

Prospective multimodal imaging assessment of locally advanced cervical cancer patients administered by chemoradiation followed by radical surgery. The PRICE (PRospective Imaging of CErvical cancer and neoadjuvant treatment) study 2: the role of ultrasound after chemoradiation to assess residual tumor

To determine the diagnostic performance of two‐dimensional (2D) ultrasound parameters, three‐dimensional (3D) power Doppler and contrast‐enhanced indices in detecting residual disease in locally advanced cervical cancer patients triaged to neoadjuvant treatment followed by radical surgery.

Role of CA125/CEA ratio and ultrasound parameters in identifying metastases to the ovaries in patients with multilocular and multilocular‐solid ovarian masses

To investigate ultrasound features and the best cut‐off value of the cancer antigen 125/carcinoembryonic antigen (CA125/CEA) ratio to discriminate ovarian metastases from benign and primary malignant ovarian neoplasms in two selected groups of morphological ovarian masses, namely multilocular masses with five or more locules and multilocular‐solid masses.

Imaging in gynecological disease (13): clinical and ultrasound characteristics of endometrioid ovarian cancer

To describe the clinical and ultrasound characteristics of ovarian pure endometrioid carcinomas.

Imaging in gynecological disease: clinical and ultrasound characteristics of ovarian clear cell carcinoma

To describe the clinical and ultrasound characteristics of ovarian pure clear cell carcinoma.

OP08.04: Clinical and ultrasound characteristics of malignant ovarian masses in pregnant women: Short oral presentation abstracts

Results The median age was 32.5 (range, 23-42) years old. 2/22 (9%) patients had a mucinous borderline tumor, 8/22 (36.4%) had a serous or endocervicaltype borderline tumor, 7/22 (31.8%) had a primary epithelial ovarian carcinoma and 5/22 (22.8%) had a metastatic tumor to the ovary. On ultrasound, mucinous ovarian borderline tumors were described as multilocular (1/2,50%) or multilocularsolid (1/2,50%) lesions, with a minimal vascularization. Serous/endocervical-type borderline tumors were described as unilocularsolid (3/8, 37.5%) or multilocular-solid (5/8, 62.5%) masses and all of them had papillary projections. Conclusion