T. Ram Reddy
Dr. Reddy's Laboratories
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Publication
Featured researches published by T. Ram Reddy.
Chemical Communications | 2011
G. Rajeshwar Reddy; T. Ram Reddy; Suju C. Joseph; K. Sateesh Reddy; L. Srinivasula Reddy; P. Mahesh Kumar; G. Rama Krishna; C. Malla Reddy; D. Rambabu; Ravikumar Kapavarapu; Chandana Lakshmi; Teja Meda; K. Krishna Priya; Kishore V. L. Parsa; Manojit Pal
A sequential Pd-mediated multi-component reaction followed by Suzuki or Heck or Sonogashira coupling in a single pot has been developed for the synthesis of functionalized pyrroles as potential inhibitors of PDE4.
RSC Advances | 2012
G. Rajeshwar Reddy; T. Ram Reddy; Suju C. Joseph; K. Sateesh Reddy; Manojit Pal
An iodine-catalyzed four-component reaction of 1,3-dicarbonyl compounds, amines, aldehydes and nitroalkanes afforded polysubstituted pyrroles under a metal free condition. Simplicity, low cost and good yields are the key features of this methodology. The mechanism of this four component process is discussed and structural elaboration of one of the compounds synthesized using Suzuki and Sonogashira coupling is presented.
Green Chemistry | 2012
T. Ram Reddy; L. Srinivasula Reddy; G. Rajeshwar Reddy; Kaviraj Yarbagi; Y. Lingappa; D. Rambabu; G. Rama Krishna; C. Malla Reddy; K. Shiva Kumar; Manojit Pal
Montmorillonite K-10 mediated green and one-pot synthesis of 2-substituted quinolines has been accomplished via a 3-component reaction of aniline, aldehydes and ethyl 3,3-diethoxypropionate in the presence of air oxygen in water. The crystal structure analysis and H-bonding patterns of one compound prepared are presented.
RSC Advances | 2012
G. Rajeshwar Reddy; T. Ram Reddy; Suju C. Joseph; K. Sateesh Reddy; Chandana Lakshmi T. Meda; Ajit Kandale; D. Rambabu; G. Rama Krishna; C. Malla Reddy; Kishore V. L. Parsa; K. Shiva Kumar; Manojit Pal
A regioselective synthesis of 1,2,3,4-tetrasubstituted pyrroles has been achieved via Yb(OTf)3-mediated 3-component reaction of amines, a 1,3-diketone and phenacyl bromide in a single pot. Yb(OTf)3 was identified as a reusable catalyst and a number of pyrrole derivatives were prepared by using this strategy. Single crystal X-ray diffraction study of a representative compound confirmed the substitution pattern on the central pyrrole ring. The crystal structure analysis of the same compound indicated the presence of a sheet-like molecular arrangement along the bc-plane present in the molecule. A possible mechanism for the regioselective formation of 1,2,3,4-tetrasubstituted pyrrole rings is discussed. A number of compounds synthesized showed PDE4 inhibitory properties when tested in vitro and two of them were identified as inhibitors of further interest.
Bioorganic & Medicinal Chemistry Letters | 2011
T. Ram Reddy; L. Srinivasula Reddy; G. Rajeshwar Reddy; Venkata Subbaiah Nuthalapati; Y. Lingappa; Sandhya Sandra; Ravikumar Kapavarapu; Parimal Misra; Manojit Pal
A multi component based synthesis involving palladium catalyzed C-C bond forming reaction has been developed as a new strategy to access systematically modified functionalized 2-aminochromenes. This MCR involves the use of bromobenzaldehyde as a key component and is highlighted by generating a new compound library. Many of these compounds showed Mycobacterium tuberculosis H37Rv chorismate mutase inhibiting properties in vitro representing the lead example of chorismate mutase inhibition by heteroarene based compounds.
European Journal of Medicinal Chemistry | 2013
T. Ram Reddy; G. Rajeshwar Reddy; L. Srinivasula Reddy; Chandana Lakshmi T. Meda; Kishore V. L. Parsa; K. Shiva Kumar; Y. Lingappa; Manojit Pal
Montmorillonite K-10 mediated MCR of anilines, arylaldehydes and ethyl-3,3-diethoxypropionate in water afforded 2,6-unsubstituted dihydropyridines depending on the nature of anilines employed. A variety of dihydropyridines were prepared by using this green methodology in good yields and montmorillonite K-10 was found to be an inexpensive and reusable catalyst. The structure elaboration of a representative compound was carried out under Heck conditions. Some of the compounds synthesized showed significant inhibition of PDE4B when tested in vitro. Docking studies indicated that one of the ester moieties of these compounds played a key role in their interactions with the PDE4B protein.
European Journal of Medicinal Chemistry | 2012
T. Ram Reddy; G. Rajeshwar Reddy; L. Srinivasula Reddy; Subbarao Jammula; Y. Lingappa; Ravikumar Kapavarapu; Chandana Lakshmi T. Meda; Kishore V. L. Parsa; Manojit Pal
Tetrahedron Letters | 2013
G. Rajeshwar Reddy; T. Ram Reddy; R. Gangadhara Chary; Suju C. Joseph; Soumita Mukherjee; Manojit Pal
Synthesis | 2012
L. Srinivasula Reddy; T. Ram Reddy; N. C. Gangi Reddy; Reddy Bodireddy Mohan; Y. Lingappa
Journal of The Korean Chemical Society | 2011
L. Srinivasula Reddy; N. C. Gangi Reddy; T. Ram Reddy; Y. Lingappa; Reddy Bodireddy Mohan