T. W. van Haeften

Association of variants of transcription factor 7-like 2 (TCF7L2) with susceptibility to type 2 diabetes in the Dutch Breda cohort

Aim/hypothesisA strong association between susceptibility to type 2 diabetes and common variants of transcription factor 7-like 2 (TCF7L2), encoding an enteroendocrine transcription factor involved in glucose homeostasis, has been reported in three different populations (Iceland, Denmark and USA) by Grant et al. We aimed to replicate these findings in a Dutch cohort.MethodsWe analysed the genotypes of two intronic single nucleotide polymorphisms (SNPs) in TCF7L2 gene in 502 unrelated type 2 diabetes patients and in a set of healthy controls (n = 920). The two SNPs showed almost complete linkage disequilibrium (D′ = 0.91).ResultsWe were able to replicate the previously reported association in our Breda cohort. The minor alleles of both variants were significantly over-represented in cases (odds ratio [OR] 1.29, 95% CI 1.09–1.52,

Reduced second phase insulin secretion in carriers of a sulphonylurea receptor gene variant associating with Type II diabetes mellitus.

p = 3 \times 10^{{ - 3}}

Does physical training increase insulin sensitivity in chronic heart failure patients

for rs12255372; OR 1.41, 95% CI 1.19–1.66,

Decreased insulin secretory capacity and normal pancreatic B‐cell glucose sensitivity in non‐obese patients with NIDDM

p = 4.4 \times 10^{{ - 5}}

Influence of gliclazide on glucose-stimulated insulin release in man

for rs7903146). In addition, TCF7L2 haplotypes were analysed for association with the disease. The analysis of haplotypes did not reveal any strong association beyond that expected from analysing individual SNPs. The TT haplotype carrying the minor alleles was more frequent among cases (OR 1.38,