T. W. van Haeften
Utrecht University
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Publication
Featured researches published by T. W. van Haeften.
Diabetologia | 2007
J. V. van Vliet-Ostaptchouk; Ronit Shiri-Sverdlov; Alexandra Zhernakova; Eric Strengman; T. W. van Haeften; Marten H. Hofker; Cisca Wijmenga
Aim/hypothesisA strong association between susceptibility to type 2 diabetes and common variants of transcription factor 7-like 2 (TCF7L2), encoding an enteroendocrine transcription factor involved in glucose homeostasis, has been reported in three different populations (Iceland, Denmark and USA) by Grant et al. We aimed to replicate these findings in a Dutch cohort.MethodsWe analysed the genotypes of two intronic single nucleotide polymorphisms (SNPs) in TCF7L2 gene in 502 unrelated type 2 diabetes patients and in a set of healthy controls (n = 920). The two SNPs showed almost complete linkage disequilibrium (D′ = 0.91).ResultsWe were able to replicate the previously reported association in our Breda cohort. The minor alleles of both variants were significantly over-represented in cases (odds ratio [OR] 1.29, 95% CI 1.09–1.52,
European Journal of Clinical Investigation | 2004
T. W. van Haeften; Th. B. Twickler
Diabetologia | 2000
Leen M. 't Hart; J. M. Dekker; T. W. van Haeften; J. B. Ruige; C. D. A. Stehouwer; D. W. Erkelens; Robert J. Heine; J. A. Maassen
p = 3 \times 10^{{ - 3}}
Current Genomics | 2009
M. G. M. Wolfs; M. H. Hofker; Cisca Wijmenga; T. W. van Haeften
Clinical Science | 2004
L.W.E. Sabelis; P.J. Senden; B.C.M. te Boekhorst; H.J. Hulzebos; A. van de Wiel; T. W. van Haeften; Maria L. Zonderland; W.L. Mosterd
for rs12255372; OR 1.41, 95% CI 1.19–1.66,
Cell and Tissue Research | 1992
T. W. van Haeften; H. Schooneveld
European Journal of Clinical Investigation | 1991
T. W. van Haeften; W. W. A. Van Maarschalkerweerd; J. E. Gerich; E. A. Vand Der Veen
p = 4.4 \times 10^{{ - 5}}
Nutrition & Diabetes | 2015
M. G. M. Wolfs; Nanda Gruben; Sander S. Rensen; Froukje J. Verdam; Jan Willem M. Greve; A. Driessen; Cisca Wijmenga; Wim A. Buurman; Lude Franke; Ludger Scheja; Debby P.Y. Koonen; Ronit Shiri-Sverdlov; T. W. van Haeften; M. H. Hofker; Jingyuan Fu
Metabolism-clinical and Experimental | 1991
T. W. van Haeften; Thiemo Veneman; J. E. Gerich; E. A. Van Der Veen
for rs7903146). In addition, TCF7L2 haplotypes were analysed for association with the disease. The analysis of haplotypes did not reveal any strong association beyond that expected from analysing individual SNPs. The TT haplotype carrying the minor alleles was more frequent among cases (OR 1.38,
Cell and Tissue Research | 1989
H. Schooneveld; H.M. Smid; P. M. Boonekamp; T. W. van Haeften
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