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Tadao Shibanuma

Saitama University

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Publication

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Synthetic Communications | 1997

One-Pot Preparation of 1-Substituted Imidazole-2-thione from Isothiocyanate and Amino Acetal

Koyo Matsuda; Isao Yanagisawa; Yasuo Isomura; Toshiyasu Mase; Tadao Shibanuma

Abstract Isothiocyanates were treated with amino acetal and conc. HCl (0.5 eq.) successively in one-pot to afford 1-substituted imidazole-2-thiones in good yields.

Synthetic Communications | 1997

Alternative Synthesis of Dibenzo-and Dipyrido-[1,3]Diazepines from Thioamides and o,o′-Diaminobiaryls

Koyo Matsuda; Isao Yanagisawa; Yasuo Isomura; Toshiyasu Mase; Tadao Shibanuma

Abstract Thioamides were treated with iodomethane, and then o,o′-diaminobiphenyl or bipyridyl to afford 6-substituted-5H-dibenzo- or dipyrido [1,3]diazepines in good yields.

Archive | 1983

1,4-Dihydropyridine derivatives

Masuo Murakami; Kozo Takahashi; Masaru Iwanami; Masaharu Fujimoto; Tadao Shibanuma; Ryutaro Kawai; Toichi Takenaka

Chemical & Pharmaceutical Bulletin | 1979

Synthesis of New Water-soluble Dihydropyridine Vasodilators

Masaru Iwanami; Tadao Shibanuma; Masaharu Fujimoto; Ryutaro Kawai; Kazuharu Tamazawa; Toichi Takenaka; Kozo Takahashi; Masuo Murakami

Chemical & Pharmaceutical Bulletin | 1980

Synthesis of Optically Active 2-(N-Benzyl-N-methylamino)ethyl Methyl 2, 6-Dimethyl-4-(m-nitrophenyl)-1, 4-dihydropyridine-3, 5-dicarboxylate (Nicardipine)

Tadao Shibanuma; Masaru Iwanani; Kouhei Okuda; Toichi Takenaka; Masuo Murakami

Chemical & Pharmaceutical Bulletin | 1998

Selective Muscarinic Antagonists. II. Synthesis and Antimuscarinic Properties of Biphenylylcarbamate Derivatives

Ryo Naito; Makoto Takeuchi; Koichiro Morihira; Masahiko Hayakawa; Ken Ikeda; Tadao Shibanuma; Yasuo Isomura

Chemical & Pharmaceutical Bulletin | 1980

Synthesis of New Cephamycin Derivatives and a Novel Rearrangement between Isothiazolethioacetamides and 1,3-Dithietanecarboxamides

Masaru Iwanami; Tetsuya Maeda; Masaharu Fujimoto; Yoshinobu Nagano; Noriaki Nagano; Atsuki Yamazaki; Tadao Shibanuma; Kazuharu Tamazawa; Kuniichiro Yano

Chemical & Pharmaceutical Bulletin | 1999

Novel Potassium Channel Activators. III. Synthesis and Pharmacological Evaluation of 3,4-Dihydro-2H-1,4-benzoxazine Derivatives : Modification at the 2 Position

Yuzo Matsumoto; Ryuji Tsuzuki; Akira Matsuhisa; Noriyuki Masuda; Yoko Yamagiwa; Isao Yanagisawa; Tadao Shibanuma; Hiroyuki Nohira

Chemical & Pharmaceutical Bulletin | 1980

Synthesis of the Metabolites of 2-(N-Benzyl-N-methylamino)ethyl Methyl 2,6-Dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride (Nicardipine Hydrochloride, YC-93)

Tadao Shibanuma; Masaru Iwanami; Masaharu Fujimoto; Toichi Takenaka; Masuo Murakami

Archive | 1985

Cephalosporin compounds, and their production, and medicaments containing them

Atsuki Yamazaki; Tadao Shibanuma; Akio Koda; Kohji Nakano; Tetsuya Maeda; Noriaki Nagano; Yukiyasu Murakami; Ryuichiro Hara

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Ryuichiro Hara

Hokkaido University

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Isao Yanagisawa

Saitama University

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Ken Ikeda

Toho University

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Toichi Takenaka

Kyorin University

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Yasuo Isomura

University of Tokyo

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Makoto Takeuchi

Astellas Pharma

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Hirokazu Kubota

Astellas Pharma

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Akira Matsuhisa

Saitama University

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Hiroyuki Nohira

Saitama University

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Noriyuki Masuda

Saitama University

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