Tadashi Hata
Tottori University
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Publication
Featured researches published by Tadashi Hata.
Journal of Electrocardiology | 1985
Hiroshi Kotake; Junichi Hasegawa; Tadashi Hata; Hiroto Mashiba
The effects of disopyramide on the membrane potentials and currents of rabbit sinus node cells were studied using the conventional microelectrode and voltage clamp methods. Disopyramide (5 and 10 micrograms/m1) produced a negative chronotropic effect, and decreased the maximum rate of depolarization, the overshoot potential and the maximum diastolic potential. The action potential duration at half-amplitude was prolonged, and the slope of diastolic depolarization was reduced. In the voltage clamp experiments, disopyramide (10 and 50 micrograms/m1) reduced the potassium outward current (IK) without changing its kinetics. Disopyramide reduced the slow inward current Isi and increased the recovery time constant of Isi. The hyperpolarization-activated current (Ih) was also decreased by the drug. From these results, it is concluded that disopyramide has a depressant effect on the electrical activity of sinus node cells by mediating depression of IK, Isi and Ih.
Japanese Circulation Journal-english Edition | 1984
Junichi Hasegawa; Takashi Kasahara; Satoshi Kuroda; Masanori Aume; Toshifumi Kosaka; Hiroshi Kotake; Narifumi Norimoto; Tadashi Hata; Tomoyuki Furuse; Hiroto Mashiba
Japanese Journal of Electrocardiology | 1985
Riichiro Ishiko; Toshiyuki Noguchi; Narifumi Norimoto; Tadashi Hata; Hiroto Mashiba; Yoshikazu Shimoda
Japanese Circulation Journal-english Edition | 1985
lchiro Hisatome; Osamu lkawa; Jiro Miyamoto; Takashi Nishigaki; Narifumi Norimoto; Hiroshi Kotake; Tadashi Hata; Hiroto Mashiba
Japanese Journal of Electrocardiology | 1984
Tadashi Hata; Takashi Nishigaki; Hiroshi Kotake; Tomoyuki Furuse; Hiroto Mashiba
Japanese Circulation Journal-english Edition | 1984
Satoshi Kuroda; Masanori Aume; Takashi Nishigaki; Toshifumi Kosaka; Tadashi Hata; Junichi Hasegawa; Hiroshi Kotake; Narifumi Norimoto; Tomoyuki Furuse; Hiroto Mashiba
Japanese Circulation Journal-english Edition | 1983
Junichi Hasegawa; Hiroo Kawamoto; Tadashi Hata; Tomoyuki Furuse; Hiroto Mashiba; Tsuguhisa Ehara
Japanese Circulation Journal-english Edition | 1983
Hiroo Kawamoto; Toshifumi Kosaka; Tadashi Hata; Tomoyuki Furuse; Hiroto Mashiba; Tadao Ito
Purine and pyrimidine metabolism | 1982
Ichiro Hisadome; Tadashi Hata; Akira Takeda; Shoshi Shimoyama; Hiroto Mashiba; Yoshihiro Ando
Japanese Journal of Electrocardiology | 1982
Hiroshi Kotake; Junichi Yamasaki; Tadashi Hata; Hiroto Mashiba
