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Tadashi Hata

Tottori University

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Journal of Electrocardiology | 1985

Electrophysiological effect of disopyramide on rabbit sinus node cells

Hiroshi Kotake; Junichi Hasegawa; Tadashi Hata; Hiroto Mashiba

The effects of disopyramide on the membrane potentials and currents of rabbit sinus node cells were studied using the conventional microelectrode and voltage clamp methods. Disopyramide (5 and 10 micrograms/m1) produced a negative chronotropic effect, and decreased the maximum rate of depolarization, the overshoot potential and the maximum diastolic potential. The action potential duration at half-amplitude was prolonged, and the slope of diastolic depolarization was reduced. In the voltage clamp experiments, disopyramide (10 and 50 micrograms/m1) reduced the potassium outward current (IK) without changing its kinetics. Disopyramide reduced the slow inward current Isi and increased the recovery time constant of Isi. The hyperpolarization-activated current (Ih) was also decreased by the drug. From these results, it is concluded that disopyramide has a depressant effect on the electrical activity of sinus node cells by mediating depression of IK, Isi and Ih.

Japanese Circulation Journal-english Edition | 1984

EFFECT OF HYPOXIA ON THE β-RECEPTOR MEDIATED SLOW CHANNEL RESPONSE OF GUINEA-PIG VENTRICULAR MUSCLE : Electrophysiology(I) : II : 48 Annual Scientific Meeting, Japanese Circulation Society

Junichi Hasegawa; Takashi Kasahara; Satoshi Kuroda; Masanori Aume; Toshifumi Kosaka; Hiroshi Kotake; Narifumi Norimoto; Tadashi Hata; Tomoyuki Furuse; Hiroto Mashiba

Japanese Journal of Electrocardiology | 1985

Transient pathologenic Q wave in a patient with epilepsy

Riichiro Ishiko; Toshiyuki Noguchi; Narifumi Norimoto; Tadashi Hata; Hiroto Mashiba; Yoshikazu Shimoda

Japanese Circulation Journal-english Edition | 1985

APRINDINE-INDUCED RATE- AND VOLTAGE-DEPENDENT DEPRESSION OF MAXIMUM RATE OF RISE OF ACTION POTENTIALS IN GUINEA-PIG PAPILLARY MUSCLE : Arrhythmias (IV) : FREE COMMUNICATIONS (VI) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY

lchiro Hisatome; Osamu lkawa; Jiro Miyamoto; Takashi Nishigaki; Narifumi Norimoto; Hiroshi Kotake; Tadashi Hata; Hiroto Mashiba

Japanese Journal of Electrocardiology | 1984

Clinical Studies Using Holter-Avionics System

Tadashi Hata; Takashi Nishigaki; Hiroshi Kotake; Tomoyuki Furuse; Hiroto Mashiba

Japanese Circulation Journal-english Edition | 1984

COMPUTER GRAPHIC ANALYSIS OF REGIONAL WALL MOTION AND LEFT VENTRICULAR DV/DT DURING LATE SYSTOLE, IN PATIENT WITH ISCHEMIC HEART DISEASE : Cardiac Function (III) : III : 48 Annual Scientific Meeting, Japanese Circulation Society

Satoshi Kuroda; Masanori Aume; Takashi Nishigaki; Toshifumi Kosaka; Tadashi Hata; Junichi Hasegawa; Hiroshi Kotake; Narifumi Norimoto; Tomoyuki Furuse; Hiroto Mashiba

Japanese Circulation Journal-english Edition | 1983

CATECHOLAMINE-INDUCED DEPOLARIZATION OF GUINEA-PIG MYOCARDIAL CELLS IN POTASSIUM-RICH SOLUTION AND ITS DEPENDENCE ON TEMPERATURE : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Electrophysiology (II)

Junichi Hasegawa; Hiroo Kawamoto; Tadashi Hata; Tomoyuki Furuse; Hiroto Mashiba; Tsuguhisa Ehara

Japanese Circulation Journal-english Edition | 1983

MODEL FOR MYOCARDIAL INFARCTION: CHANGES OF SERUM CATECHOLAMINE AND β-ADRENOCEPTORS : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Myocardial Metabolism Biochemistry

Hiroo Kawamoto; Toshifumi Kosaka; Tadashi Hata; Tomoyuki Furuse; Hiroto Mashiba; Tadao Ito

Purine and pyrimidine metabolism | 1982

A Case of Transient Hypouricemia Associated with Drug-Induced Liver Disorder in Reference to Uric Acid Concentration Observed in Normal Subjects and Admitted Patients

Ichiro Hisadome; Tadashi Hata; Akira Takeda; Shoshi Shimoyama; Hiroto Mashiba; Yoshihiro Ando

Japanese Journal of Electrocardiology | 1982

Effects of disopyramide on electrophysiologic actions of rabbit sinus node cells

Hiroshi Kotake; Junichi Yamasaki; Tadashi Hata; Hiroto Mashiba

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Hiroto Mashiba

Kyushu University

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Hiroshi Kotake

Tottori University

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Tomoyuki Furuse

Tottori University

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Narifumi Norimoto

Tottori University

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Satoshi Endo

Tottori University

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Hisaichi Ishida

Tottori University

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Junichi Hasegawa

Tottori University

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Masanori Aume

Tottori University

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Hiromu Oda

Tottori University

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Naoto Hanazono

Tottori University

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