Tadashi Kajii

A long Y chromosome in man

SummaryAn unusually long Y chromosome was described in the phenotypically normal father and paternal grandfather of a girl with Downs syndrome, and likewise in a male infant with multiple malformations and his father, normal in phenotype. Measurements revealed that the long Y chromosome corresponded in length to autosomes of group 16–18.Information was obtained to show that the increased length of the Y chromosome was an inheritable character, and that a long Y chromosome was not always associated with an abnormal phenotype (or phenotypes).

Chromosome aberrations in leucocytes of patients with aseptic meningitis

SummaryThree patients with aseptic meningitis and two patients with scarlet fever were subjected to chromosome analysis in cultured leucocytes. Information was obtained that leucocytes of the aseptic meningitis patients exhibit random and non-specific chromosome aberrations significantly higher in frequency than the control series from scarlet fever patients. The most common type of the aberration observed was a single chromatid break including a full break in one chromatid. Isochromatid-type breaks, chromatid- and chromosome-type interchanges and acentric fragments were observed less frequently.

Concordant metaphyseal dysostosis type Schmid in identical twins

SummaryMetaphyseal dysostosis type Schmid has been described in identical twin girls. It was concluded that the concordant occurrence of the disease in the twins was the result of a fresh autosomal dominant mutation.