Tadateru Takahashi
West Japan Railway Company
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Featured researches published by Tadateru Takahashi.
Pathobiology | 2004
Hiroki Kuniyasu; Takamitsu Sasaki; Tomonori Sasahira; Hitoshi Ohmori; Tadateru Takahashi
Macrophage infiltration into colon cancer and amphoterin expression in cancer cells was examined in 42 human colon cancers invading the subserosa. The mean number of infiltrating macrophages was significantly higher in Dukes’ B cases than in Dukes’ C cases (p = 0.0065). Tumors with few infiltrating macrophages (macrophage depletion) were significantly more frequent in Dukes’ C cases than in Dukes’ B cases (p = 0.0014). No Dukes’ C cases with relevant macrophage infiltration showed macrophage-cancer cell contact, whereas 5 Dukes’ B cases showed such contact (p < 0.0001). In human colon cancer cells implanted in the cecum of nude mice, KM12SM (highly metastatic) tumors yielded less macrophage infiltration and more liver metastases than KM12C (low risk of metastasis) tumors (14 ± 3 vs. 78 ± 32 and 24 ± 6 vs. 5 ± 3 per liver, respectively). Amphoterin expression was detected at high frequency in both Dukes’ B and C cases (p = 0.0684). In macrophage-depleted cases, amphoterin expression was significantly higher than that in non-depleted cases (p = 0.0015). To confirm biological effects of amphoterin on macrophages, an infiltration assay using the cell-layered Boyden chamber was done. Infiltration of PMA-treated U937 monocytes through the KM12SM cell layer was increased by pretreatment of KM12SM cells with amphoterin antisense S-oligodeoxynucleotide exposure. Moreover, extracted amphoterin inhibited PMA-U937 monocyte infiltration in a dose-dependent manner. Thus, amphoterin may play an important role in the inhibition of macrophage infiltration into colon cancer.
Gastroenterology Research and Practice | 2010
Masahiro Kawanishi; Yukio Kuwada; Yutaka Mitsuoka; Shogo Sasao; Teruo Mouri; Eiichi Takesaki; Tadateru Takahashi; Kazuhiro Toyota; Tamaki Nakatani
Double gallbladder is a rare congenital biliary anomaly, but an accessory gallbladder arising from the left hepatic duct is a more remarkably rare congenital anomaly. We report a case of double gallbladder with adenocarcinoma and gallstones, which was preoperatively diagnosed by endoscopic retrograde cholangiopancreatography (ERCP) and then confirmed by open laparotomy. A review of the literature is presented.
Journal of the Anus, Rectum and Colon | 2017
Manabu Shimomura; Kazuhiro Toyota; Nozomi Karakuchi; Kosuke Ono; Naofumi Tsukiyama; Masayuki Shishida; Koichi Oishi; Kazuaki Miyamoto; Masahiro Ikeda; Seiji Sadamoto; Tadateru Takahashi
Objectives: Palliative surgeries such as stoma creation and bypass are effective for relieving symptoms related to incurable abdominal malignancies; however, these methods are controversial in patients with severe metastatic disease or poor pre-surgical health. The aim of this study was to examine the clinical significance of the prognostic nutritional index (PNI) in evaluations for palliative surgery. Methods: We retrospectively analyzed data from 37 patients who underwent palliative surgery for histologically-proven colorectal adenocarcinoma from 2009 to 2015. We investigated both risk factors for postoperative complications and prognostic factors. We used a PNI cutoff value of 40, as defined by previous studies. Results: The reason for surgery was stenosis in 18 patients, obstruction in 12, fistula in 5, and bleeding in 2. Bypass was performed in 10 cases, ileostomy in 5, and colostomy in 22. Postoperative morbidity and mortality occurred in 9 and 2 patients, respectively. Median overall survival time was 8.9 months. Only low PNI correlated with postoperative complications at trend-level (p=0.07), and the 2 patients with mortality were classified as PNI-low. The presence of ascites (p=0.003) and PNI (p=0.02) were identified as independent prognostic factors. Conclusions: PNI could be used as an objective marker for deciding whether to proceed with palliative surgery, independent of the extent of metastatic disease.
Case Reports in Gastroenterology | 2017
Masayuki Shishida; Masahiro Ikeda; Nozomi Karakuchi; Kosuke Ono; Naofumi Tsukiyama; Manabu Shimomura; Koichi Oishi; Kazuaki Miyamoto; Kazuhiro Toyota; Seiji Sadamoto; Tadateru Takahashi
The present paper describes a case of hemorrhagic cholecystitis in a patient on maintenance dialysis. The patient presented with right upper quadrant abdominal pain. Computed tomography revealed swelling of the gallbladder, high- and isodensity contents of the gallbladder, and high-density stone in the gallbladder neck. He was hospitalized for suspected acute cholecystitis. After hospitalization, his levels of total bilirubin, aspartate aminotransferase, and alanine aminotransferase increased. T2-weighted magnetic resonance imaging showed low-intensity contents expanded to include a wide area from the common bile duct to the cystic duct and gallbladder neck. Endoscopic retrograde cholangiopancreatography revealed clotting from the duodenal papilla. After cannulation of the bile duct, old blood and pus began to flow from the mammary papilla, and an endoscopic nasobiliary drainage tube was placed. After his liver function had improved, the patient underwent laparoscopic cholecystectomy. His sample revealed that the gallbladder was filled with blood clots and stones. His postoperative course was uneventful and he was discharged on day 19 after the procedure. Although hemorrhagic cholecystitis is rare, it should be considered as a differential diagnosis for patients on dialysis who have acute abdominal symptoms.
Oncology Reports | 2003
Hiroki Kuniyasu; Yoshitomo Chihara; Tadateru Takahashi
International Journal of Molecular Medicine | 2002
Hiroki Kuniyasu; Yoshitomo Chihara; Tadahiko Kubozoe; Tadateru Takahashi
Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 2001
Hiroyuki Naito; Takayuki Nomimura; Tadateru Takahashi; Masahiro Ikeda; Norio Masumoto; Yoshitaka Kato
Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 1998
Kentaro Emoto; Tadateru Takahashi; Takayuki Nomimura; Ichiro Omori; Hajime Hayashi; Yoshitaka Kato
Nihon Rinsho Geka Gakkai Zasshi (journal of Japan Surgical Association) | 1997
Kentaro Emoto; Tadateru Takahashi; Yoshitaka Kato; Takayuki Nomimura; Ichiro Omori; Hajime Hayashi; Toshiyuki Iwamoto; Seiji Fujisaki
Nippon Daicho Komonbyo Gakkai Zasshi | 2008
Kazuhiro Toyota; Tadateru Takahashi; Masahiro Ikeda; Noriaki Tokumoto