Tadeusz A. Wysocki

A review of routing protocols for mobile ad hoc networks

Abstract The 1990s have seen a rapid growth of research interests in mobile ad hoc networking. The infrastructureless and the dynamic nature of these networks demands new set of networking strategies to be implemented in order to provide efficient end-to-end communication. This, along with the diverse application of these networks in many different scenarios such as battlefield and disaster recovery, have seen MANETs being researched by many different organisations and institutes. MANETs employ the traditional TCP/IP structure to provide end-to-end communication between nodes. However, due to their mobility and the limited resource in wireless networks, each layer in the TCP/IP model require redefinition or modifications to function efficiently in MANETs. One interesting research area in MANET is routing. Routing in the MANETs is a challenging task and has received a tremendous amount of attention from researches. This has led to development of many different routing protocols for MANETs, and each author of each proposed protocol argues that the strategy proposed provides an improvement over a number of different strategies considered in the literature for a given network scenario. Therefore, it is quite difficult to determine which protocols may perform best under a number of different network scenarios, such as increasing node density and traffic. In this paper, we provide an overview of a wide range of routing protocols proposed in the literature. We also provide a performance comparison of all routing protocols and suggest which protocols may perform best in large networks.

The Theory of Quaternion Orthogonal Designs

Over the past several years, there has been a renewed interest in complex orthogonal designs for their application in space-time block coding. Motivated by the success of this application, this paper generalizes the definition of complex orthogonal designs by introducing orthogonal designs over the quaternion domain. This paper builds a theory of these novel quaternion orthogonal designs, offers examples, and provides several construction techniques. These theoretical results, along with the results of preliminary simulations, lay the foundation for developing applications of these designs as orthogonal space-time-polarization block codes.

Scalability of MANET routing protocols for heterogeneous and homogenous networks

In Mobile Ad hoc Network (MANET), mobility, traffic and node density are main network conditions that significantly affect performance of routing protocols. Much of the previous research in MANET routing have focused on developing strategies, which suit one specific networking scenario. Therefore, there is no existing protocol that can work well in all different networking scenarios. This paper reviews characteristics of several different classes of routing protocols. Moreover, most of current routing protocols assume homogeneous networking conditions where all nodes have the same capabilities and resources. This paper presents extensive studies simulations for DSR, AODV, LAR1, FSR and WRP in homogenous and heterogeneous networks that consist of different nodes with different resources. The results showed that while all protocols perform reasonably well in homogenous networking conditions, their performance suffer significantly over heterogonous networks.

Fading measurements at 2.4 GHz for the indoor radio propagation channel

To design efficient modulation and error control schemes for wireless local area networks, characterisation of signal fading is required. In this paper, we present fading measurements gathered for the indoor propagation channel at 2.4 GHz. A statistical analysis of the measurements was undertaken and the obtained fading distributions, level crossing rates, and average duration of fades are presented and discussed.

Simulation of capture behaviour in IEEE 802.11 radio modems

We investigate the performance of common capture models in terms of the fairness properties they reflect across contenting hidden connections. We propose a new capture model, message retraining, as a means of providing an accurate description of experimental data. Using two fairness indices we undertake a quantitative study of the accuracy with which each capture model is able to reflect experimental data. Standard capture models are shown to be unable to accurately reflect the fairness properties of empirical data. The message retraining capture model is shown to provide a good estimate of actual system performance in varying signal strength conditions.

On Optimising Route Discovery in Absence of Previous Route Information in MANETs

This paper present a new routing protocol for Ad hoc networks, called On-demand Tree-based Routing Protocol (OTRP). This protocol combines the idea of hop-by-hop routing such as AODV with an efficient route discovery algorithm called Tree-based Optimized Flooding (TOF) to improve scalability of Ad hoc networks when there is no previous knowledge about the destination. To achieve this in OTRP, route discovery overheads are minimized by selectively flooding the network through a limited set of nodes, referred to as branching-nodes. The theoretical analysis and simulation results showed that OTRP outperforms AODV, DYMO, and OLSR and it reduces overheads as number of nodes and traffic increase.

Endosomal Trafficking of Nanoformulated Antiretroviral Therapy Facilitates Drug Particle Carriage and HIV Clearance

ABSTRACT Limitations of antiretroviral therapy (ART) include poor patient adherence, drug toxicities, viral resistance, and failure to penetrate viral reservoirs. Recent developments in nanoformulated ART (nanoART) could overcome such limitations. To this end, we now report a novel effect of nanoART that facilitates drug depots within intracellular compartments at or adjacent to the sites of the viral replication cycle. Poloxamer 407-coated nanocrystals containing the protease inhibitor atazanavir (ATV) were prepared by high-pressure homogenization. These drug particles readily accumulated in human monocyte-derived macrophages (MDM). NanoATV concentrations were ∼1,000 times higher in cells than those that could be achieved by the native drug. ATV particles in late and recycling endosome compartments were seen following pulldown by immunoaffinity chromatography with Rab-specific antibodies conjugated to magnetic beads. Confocal microscopy provided cross validation by immunofluorescent staining of the compartments. Mathematical modeling validated drug-endosomal interactions. Measures of reverse transcriptase activity and HIV-1 p24 levels in culture media and cells showed that such endosomal drug concentrations enhanced antiviral responses up to 1,000-fold. We conclude that late and recycling endosomes can serve as depots for nanoATV. The colocalization of nanoATV at endosomal sites of viral assembly and its slow release sped antiretroviral activities. Long-acting nanoART can serve as a drug carrier in both cells and subcellular compartments and, as such, can facilitate viral clearance. IMPORTANCE The need for long-acting ART is significant and highlighted by limitations in drug access, toxicity, adherence, and reservoir penetrance. We propose that targeting nanoformulated drugs to infected tissues, cells, and subcellular sites of viral replication may improve clinical outcomes. Endosomes are sites for human immunodeficiency virus assembly, and increasing ART concentrations in such sites enhances viral clearance. The current work uncovers a new mechanism by which nanoART can enhance viral clearance over native drug formulations.

Fading characteristics for indoor wireless channels at 5 GHz unlicensed bands

The paper reports on experiments undertaken at the University of Wollongong to characterise fading profiles of indoor wireless channels at the 5 GHz bands. The measurements were undertaken at different locations around the campus with results recorded for post-processing to calculate the Rician k-factor, the level crossing rate and the average fade duration.

Modelling and comparative performance analysis of a time-reversed UWB system

The effects of multipath propagation lead to a significant decrease in system performance in most of the proposed ultra-wideband communication systems. A time-reversed system utilises the multipath channel impulse response to decrease receiver complexity, through a prefiltering at the transmitter. This paper discusses the modelling and comparative performance of a UWB system utilising time-reversed communications. System equations are presented, together with a semianalytical formulation on the level of intersymbol interference and multiuser interference. The standardised IEEE 802.15.3a channel model is applied, and the estimated error performance is compared through simulation with the performance of both time-hopped time-reversed and RAKE-based UWB systems.

The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy

During studies to extend the half-life of crystalline nanoformulated antiretroviral therapy (nanoART) the mixed lineage kinase-3 inhibitor URMC-099, developed as an adjunctive neuroprotective agent was shown to facilitate antiviral responses. Long-acting ritonavir-boosted atazanavir (nanoATV/r) nanoformulations co-administered with URMC-099 reduced viral load and the numbers of HIV-1 infected CD4+ T-cells in lymphoid tissues more than either drug alone in infected humanized NOD/SCID/IL2Rγc-/- mice. The drug effects were associated with sustained ART depots. Proteomics analyses demonstrated that the antiretroviral responses were linked to affected phagolysosomal storage pathways leading to sequestration of nanoATV/r in Rab-associated recycling and late endosomes; sites associated with viral maturation. URMC-099 administered with nanoATV induced a dose-dependent reduction in HIV-1p24 and reverse transcriptase activity. This drug combination offers a unique chemical marriage for cell-based viral clearance. From the Clinical Editor: Although successful in combating HIV-1 infection, the next improvement in antiretroviral therapy (nanoART) would be to devise long acting therapy, such as intra-cellular depots. In this report, the authors described the use of nanoformulated antiretroviral therapy given together with the mixed lineage kinase-3 inhibitor URMC-099, and showed that this combination not only prolonged drug half-life, but also had better efficacy. The findings are hoped to be translated into the clinical setting in the future.