Tadeusz Stacewicz

Ultrasensitive laser spectroscopy for breath analysis

At present there are many reasons for seeking new methods and technologies that aim to develop new and more perfect sensors for different chemical compounds. However, the main reasons are safety ensuring and health care. In the paper, recent advances in the human breath analysis by the use of different techniques are presented. We have selected non-invasive ones ensuring detection of pathogenic changes at a molecular level. The presence of certain molecules in the human breath is used as an indicator of a specific disease. Thus, the analysis of the human breath is very useful for health monitoring. We have shown some examples of diseases’ biomarkers and various methods capable of detecting them. Described methods have been divided into non-optical and optical methods. The former ones are the following: gas chromatography, flame ionization detection, mass spectrometry, ion mobility spectrometry, proton transfer reaction mass spectrometry, selected ion flow tube mass spectrometry. In recent twenty years, the optical methods have become more popular, especially the laser techniques. They have a great potential for detection and monitoring of the components in the gas phase. These methods are characterized by high sensitivity and good selectivity. The spectroscopic sensors provide the opportunity to detect specific gases and to measure their concentration either in a sampling place or a remote one. Multipass spectroscopy, cavity ring-down spectroscopy, and photo-acoustic spectroscopy were characterised in the paper as well.

Analytical function for lidar geometrical compression form-factor calculations.

A simple model of image formation in a Newtonian telescope was used for calculating an analytical formula, that describes the geometric compression form factors of coaxial and biaxial lidars. Calculations were successfully validated by comparison with real measurements, confirming the accuracy of our approach. The need for different alignment of coaxial and biaxial systems to increase the overlap between the lidar emitter and receiver is also discussed.

Detection of volatile organic compounds as biomarkers in breath analysis by different analytical techniques

Breath is a rich mixture containing numerous volatile organic compounds at trace amounts (ppbv-pptv level) such as: hydrocarbons, alcohols, ketones, aldehydes, esters or heterocycles. The presence of some of them depends on health status. Therefore, breath analysis might be useful for clinical diagnostics, therapy monitoring and control of metabolic or biochemical cell cycle products. This Review presents an update on the latest developments in breath analysis applied to diagnosing different diseases with the help of high-quality equipment. Efforts were made to fully and accurately describe traditional and modern techniques used to determine the components of breath. The techniques were compared in terms of design, function and also detection limit of different volatile organic compounds. GC with different detectors, MS, optical sensor and laser spectroscopic detection techniques are also discussed.

Cavity Ring-Down Absorption Spectrography based on filament-generated supercontinuum light

We performed simultaneous, multispectral CRDS measurements that for the first time use the Supercontinuum light source. We called this approach Supercontinuum Cavity Ring-Down Spectrography (SC CRDSpectrography) and successfully applied it to measuring the absorption spectrum of NO2 gas at a concentration of 2 ppm. The extrapolated sensitivity of our setup was much greater, about 5 ppb. The ppb sensitivity level is comparable to this obtainable with single wavelength dye-lasers based CRDS systems. It is, therefore, feasible to construct extremely broadband and sensitive CRDS devices basing on the SC CRDSpectrography scheme.

Cavity ring-down spectrography

We propose a modified cavity ring-down spectroscopy (CRDS) technique. A pulsed broad band laser is applied as a light source while a spectrograph equipped with gated ICCD camera is used for the signal detection. The signal is simultaneously analyzed at various wavelengths within the laser line width. It allows to get the information on absorption spectra much faster and more reliable than by means of classical CRDS method with tunable laser.

Observation of ozone concentration during the solar eclipse

Abstract We report the results of measurements of ozone concentrations during the solar eclipse of 11 August 1999. The experiment was performed in Warsaw (Poland) and its surroundings. The temporal evolution of ozone concentration was measured using the differential absorption lidar (DIAL) and it was compared with results obtained by several monitoring stations measuring with other methods. In almost all cases, a drop in the ozone concentration was observed during the eclipse. Experimental data was compared with calculations done using a simple model based on NO x –O 3 chemical kinetics.

Particle size distribution retrieval from multiwavelength lidar signals for droplet aerosol

A method of retrieval of the aerosol particle size distribution (APSD) from multiwavelength lidar signals is presented. Assumed distribution (usually a bimodal combination of lognormal functions) with a few free parameters is directly substituted into the lidar equations. The minimization technique allows one to find the parameters that provide the best fit of the assumed APSD by comparison of theoretically generated and experimental signals. Prior knowledge of the lidar ratio is not required. The approach was tested on a typical synthetic APSD consisting of spherical droplets. Comparison of lidar measurements with results from a condensation particle counter was also performed. For signals registered at 3-5 wavelengths from the UV to the near IR a satisfactory retrieval of synthetic APSD is possible for the particles within the 100-3000 nm range.

Towards optoelectronic detection of explosives

Detection of explosives is an important challenge for contemporary science and technology of security systems. We present an application of NOx sensors equipped with concentrator in searching of explosives. The sensors using CRDS with blue — violet diode lasers (410 nm) as well as with QCL lasers (5.26 μm and 4.53 μm) are described. The detection method is based either on reaction of the sensors to the nitrogen oxides emitted by explosives or to NOx produced during thermal decomposition of explosive vapours. For TNT, PETN, RDX, and HMX the detection limit better than 1 ng has been achieved.

Cavity ring down spectroscopy: detection of trace amounts of substance

We describe several applications of cavity ring-down spectroscopy (CRDS) for trace matter detection. NO2 sensor was constructed in our team using this technique and blue-violet lasers (395–440 nm). Its sensitivity is better than single ppb. CRDS at 627 nm was used for detection of NO3. Successful monitoring of N2O in air requires high precision mid-infrared spectroscopy. These sensors might be used for atmospheric purity monitoring as well as for explosives detection. Here, the spectroscopy on sharp vibronic molecular resonances is performed. Therefore the single mode lasers which can be tuned to selected molecular lines are used. Similarly, the spectroscopy at 936 nm was used for sensitive water vapour detection. The opportunity of construction of H2O sensor reaching the sensitivity about 10 ppb is also discussed.

Study of Vertical Structure of Aerosol Optical Properties with Sun Photometers and Ceilometer During the MACRON Campaign in 2007

This paper presents the measurements of a vertical structure of aerosol optical properties performed during the MACRON (Maritime Aerosol, Clouds and Radiation Observation in Norway) campaign, which took place in July and August 2007 at ALOMAR observatory on Andøya island (69.279°N, 16.009°E, elevation 380 m a.s.l.). The mean value of the aerosol optical thickness (AOT) at 500 nm during campaign was 0.12. Significant increase of the AOT above longtime mean value was observed on 7 and 8 August 2007 when the AOT exceeded 0.4 at 500 nm. Analyses of back trajectories show the aerosol transported from over Africa and Central Europe. The aerosol extinction coefficient obtained from the synergy of ceilometer and sun photometer observations reached 0.05–0.08 km−1 (at 1064 nm) in the dust layer. The single scattering albedo at the ALOMAR observatory decreased during the dust episode to 0.93–0.94, which indicates some absorptive aerosols in the lower PBL.