Tae Kun An
Chonbuk National University
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Publication
Featured researches published by Tae Kun An.
International Journal of Pharmaceutics | 2003
Hasoo Seong; Tae Kun An; Gilson Khang; Sang-Un Choi; Chong Ock Lee; Hai Bang Lee
Implantable polymeric device that can release chemotherapeutic agent directly into central nervous system (CNS) has had an impact on malignant glioma therapy. The purpose of our study was to develop an implantable polymeric device, which can release intact 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) for long-term period over 1 month, and to evaluate its cytotoxicity against XF 498 human CNS tumor cells in vitro. BCNU was incorporated into biodegradable poly(D,L-lactide-co-glycolide) (PLGA), by using spray-drying method. BCNU-loaded PLGA microparticles were characterized by scanning electron microscopy (SEM), powder X-ray diffraction, and differential scanning calorimetry. SEM observation of the microparticles showed that the microparticles were spherical, i.e. microspheres. Homogeneous distribution of BCNU in PLGA microsphere was confirmed by significant reduction of crystallinity of BCNU. Microspheres were fabricated into wafers with flat and smooth surface by direct compression method. In vitro release of BCNU in pH 7.4 phosphate buffered saline was prolonged up to 8 weeks after short initial burst period. Antitumor activity of BCNU-loaded PLGA wafer against XF 498 human CNS tumor cells continued over 1 month and, PLGA only did not affect the growth of the cells. Meanwhile, the cytotoxic activity of BCNU powder disappeared within 12 h. These results strongly suggest that the BCNU/PLGA formulations increase release period of carmustine in vivo and also be useful in the development of implantable polymeric device for malignant glioma.
Macromolecular Research | 2003
Jin Soo Lee; Gang Soo Chae; Tae Kun An; Gil Son Khang; Sun Hang Cho; Hai Bang Lee
The controlled delivery of anticancer agents using biodegradable polymeric implant has been developed to solve the problem of penetration of blood brain barrier and severe systemic toxicity. This study was performed to prepare 5-FU-loaded poly(L-lactide-co-glycolide) (PLGA) wafer fabricated microparticles prepared by two different method and to evaluate their release profile for the application of the treatment of brain tumor. 5-FU-loaded PLGA microparticles were characterized by scanning electron microscopy (SEM), powder X-ray diffraction (XRD), and differential scanning calorimetry (DSC). SEM observation of the 5-FU-loaded PLGA microparticles prepared by rotary solvent evaporation method showed that 5-FU was almost surrounded by PLGA and significant reduction of crystallinity of 5-FU was confirmed by XRD. In case of release profile of 5-FU from 5-FU-loaded PLGA wafer fabricated microparticles prepared by mechanical mixing, the release profile of 5-FU followed near first order release kinetics. In contrast to the above result, release profile of 5-FU from 5-FU-loaded PLGA wafer fabricated microparticles prepared by rotary solvent evaporation method followed near zero order release kinetics. These results indicate that preparation method of the 5-FU-loaded PLGA microparticles to fabricate into wafers was contributed to drug release profile.
European Journal of Pharmaceutics and Biopharmaceutics | 2005
Jin Soo Lee; Tae Kun An; Gang Soo Chae; Je Kyo Jeong; Sun Hang Cho; Hai Bang Lee; Gilson Khang
Archive | 2007
Hyun Jung Noh; Cheong Weon Cho; Jeong Ku; Taek Rho Kim; Hee Chol Kang; Qing Ri Cao; Eun Young Yang; Tae Kun An; Eun Kyung Jeon; Jae Kyoung Ko; Hye Suk Hong; Il Hwan Kim; Hea Ran Suh; Hye Jin Han; Gang Soo Chae
Archive | 2010
Il Hwan Cho; 조일환; Oh Eok Kwon; 권오억; Tae Kun An; 안태군; Chi Hye Park; 박지혜; Young Mee Chung; 정영미; Nak Hyun Choi; 최낙현; Bo Hyun Sung; 성보현; Young Ryool Kim; 김영률
Archive | 2002
Tae Kun An; Hui Jung Kang; Jin Soo Lee; Hasoo Seong; Je Kyo Jeong; Gilson Khang; Yongkil Hong; Hai Bang Lee; Banpo Dong
publisher | None
author
Archive | 2015
서혜란; Hea Ran Suh; 안태군; Tae Kun An; 최주현; Ju Huen Choi; 오승연; Seung Youn Oh; 김아람; A Ram Kim; 김종민; Jong Min Kim; 안국환; Gug Hwan An; 남윤진; Yoon Jin Nam; 전대연; Dae Yeon Jeon; 오영흔; Young Heun Oh; 한상민; Sang Min Han; 배민희; Min Hee Bae
Archive | 2013
Il Hwan Cho; ファン チョ,イル; Il Ki Hong; キ ホン,イル; Tae Kun An; クン アン,テ; Yong Taek Lee; テク リー,ヨン; Seon Oh Jeong; オー チョン,セオン; Myeong Sik Yoon; シク ユン,ミョン; Oh Eok Kwon; エク クウォン,オー; Si Beum Lee; ボム リー,シ; Da Won Oh; ウォン オー,ダ; Nak Hyun Choi; ヒュン チョイ,ナク; Hee Jeong Lee; チョン リー,ヘー; Hyun Jung Noh; ジュン ノー,ヒュン
Archive | 2009
Yong Tack Lee; 이용택; Myeong Sik Yoon; 윤명식; Hye Suk Hong; 홍혜숙; Il Hwan Cho; 조일환; Tae Kun An; 안태군; Si Beum Lee; 이시범; Hae Jong Jang; 장해종; Mi Kyung Park; 박미경