Tae-Sung Kim

Detection of Hepatic Metastases Using Dual-Time-Point FDG PET/CT Scans in Patients with Colorectal Cancer

PurposeThe purpose of this study was to determine the most useful parameter of dual-time-point 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography/computed tomography (PET/CT) for detection of hepatic metastases in patients with colorectal cancer.ProceduresThirty-nine patients had undergone a dual-time-point PET/CT scan and a subsequent histopathological confirmation for a workup of hepatic metastases. Detection rates were compared for visual analysis score, standardized uptake value (SUV), tumor-to-liver uptake ratio (TLR), and percent changes of the SUV and TLR.ResultsOf 91 liver lesions, 86 lesions were confirmed as metastases. The SUV and TLR of metastatic lesions on the delayed images were higher than those on the first scan (p < 0.001). The signal-to-noise ratio of the delayed PET scan was higher than that of the first scan (p < 0.0001). The TLR and SUV of the delayed scan showed the highest detection rates of 92% and 88%, whereas percent changes of SUV and TLR showed the lowest detection rates (51%, 67%). Visual analysis detected 87% on the delayed scan and 77% on the first scan.ConclusionsA delayed scan is more favorable for the detection of hepatic metastases of colorectal cancer, and the TLR on the delayed scan was the most useful parameter.

16.2: Advanced TFT-LCD Data Line Reduction Method

A new multiplexing technique has been developed which eliminates 2/3 of the TFT-LCD data lines and column drivers by rearranging horizontally-placed RGB pixels vertically. The method requires three times the number of gate drivers, which in turn are integrated in α-Si silicon onto the glass substrate. This new method has been successfully tested and verified on a 12.1-inch WXGA TFT-LCD panel using only two data driver ICs.

Improved Prognostic Value of Standardized Uptake Value Corrected for Blood Glucose Level in Pancreatic Cancer Using F-18 Fdg Pet

Background: The purpose of this study was to determine the effect of blood glucose level correction on pancreatic cancer prognosis predictions after curative resection using F-18 fluorodeoxyglucose positron emission tomography (FDG PET). Methods: We enrolled 43 patients with pancreatic cancer who underwent preoperative FDG PET. Patient outcomes were categorized according to cancer recurrence in the clinical period. Maximum standardized uptake values (SUVmax) of tumors were measured using FDG PET, and blood glucose-corrected SUV (SUVgluc) was calculated as SUVmax × blood glucose level/100. Results: Pancreatic cancer recurrence was observed within 9 months in 24 of 43 patients. SUVgluc, but not SUVmax, was significantly higher in the recurrence group than in the nonrecurrence group. Receiver operating characteristic analysis revealed that SUVgluc of 4.8 and SUVmax of 3.0 were the best cutoff values for predicting tumor recurrence. The 9-month recurrence-free survival rates were 72.3% for patients with SUVgluc ≤4.8, 23.5% for patients with SUVgluc >4.8, 75.0% for patients with SUVmax ≤3.0, and 45.0% for patients with SUVmax >3.0. SUVgluc was determined to be a significant predictive factor for tumor recurrence, along with differentiation, whereas SUVmax was not. Conclusion: SUVgluc on FDG PET aids in better predicting the prognosis of patients with pancreatic cancer after curative resection than does SUVmax without correction.

69.1: Invited Paper: Advancements for Highest-Performance LCD-TV

Samsung continues to pursue state-of-the-art performance to propel the LCD-TV market. Past issues for LCD-TV have included achievement of high contrast ratio, preservation of low light detail, color tracking and color accuracy, high luminance and color uniformity, and high performance over a wide angle of view. As these are now legacy issues, Samsung has turned its attention to the last major performance challenge for LCD-TV, which is faithful motion image reproduction. This paper will consider the various approaches being taken to address this issue, then will describe new technology to counteract the problem, including a new panel structure to enable high speed driving. Additionally, Samsung has just announced groundbreaking of its 8th generation LCD-TV panel facility. This new development, which will enable highly efficient mass-production of >50″ screens, will also be reported.

60.1: Response Time Compensation for Black Frame Insertion

Black frame insertion has been widely adopted for better motion quality in LCDs. In order to maximize the blur reduction effect, fast temporal response is also critical. In this paper, the special behavior of LC molecules in a black insertion environment has been analyzed, and we propose an effective means to implement Response Time Compensation (RTC) with black insertion.

F-18 fluorodeoxyglucose and F-18 fluorothymidine positron emission tomography/computed tomography imaging in a case of neurosarcoidosis.

Purpose: F-18 fluorothymidine (FLT) PET/CT is considered more specific for malignancy than F-18 fluorodeoxyglucose (FDG) PET/CT. This case report presents F-18 FLT and F-18 FDG scans of a patient with neurosarcoidosis. Materials and Methods: We describe a 34-year-old man who presented with myelopathic symptoms and signs. The patients evaluation included serological tests for systemic autoimmunity, CSF analysis, magnetic resonance imaging of the spinal cord and brain, abdominal CT, whole-body F-18 FDG and F-18 FLT PET/CT, and high-resolution chest CT. The patient finally underwent transbronchial mediastinal lymph node biopsy for definite diagnosis. Results: The neurologic symptoms were relapsing and remitting. Magnetic resonance imaging demonstrated corresponding abnormal lesions in the spinal cord. Under a tentative diagnosis of multiple sclerosis, the patient was treated with beta-interferon, which showed no beneficial effect. Abdominal CT for evaluation of unexplained abdominal discomfort revealed abdominal lymphadenopathies. F-18 FDG PET/CT showed multiple symmetrical intense accumulations of F-18 FDG on mediastinal and abdominal lymph nodes, whereas only faint to mild F-18 FLT accumulations were observed. Biopsy of mediastinal lymph nodes indicated nontuberculous granulomatous disease. A final diagnosis of neurosarcoidosis was made, and his clinical symptoms and signs were markedly improved by immunosuppressive treatment. Conclusions: Multiple F-18 FDG-avid lymphadenopathies with mild F-18 FLT uptake can be characteristic findings of sarcoidosis. The combination of F-18 FDG and F-18 FLT PET/CT can be helpful in differentiating granulomatous inflammatory diseases such as neurosarcoidosis from malignancy and in localizing the most appropriate biopsy site of active sarcoidosis.

P‐51: Advanced Method for Motion‐Blur Reduction in LCDs

Recently there have been many attempts to reduce motion artifacts in LCDs. However, motion blur caused by the sample-and-hold driving inherent in LCDs is still a limitation for high-quality LCD TV applications. In this paper, we present an effective method called cyclic data blanking (CDB) to improve motion image quality and to minimize flickering effects and ghost images.

New era for TFT‐LCD size and viewing‐angle performance

— Samsung has announced the development of a full-high-definition (1920 × 1080) 82-in. TFT-LCD panel using Super-PVA (S-PVA) technology, the worlds largest TFT-LCD. In addition to the size breakthrough, this product achieves 600 nits of brightness, a contrast ratio of over 1200:1, an angle of view of 180°, a color gamut of 92%, and an 8-msec response time. Several key enabling technologies were developed to achieve these specifications, including two-transistor direct-driven independently controlled S-PVA subpixels, non-even-area-ratio subpixels for optimal off-axis gamma, gate overlap driving for larger driving margin, new CCFL technology for higher color gamut, and advanced fabrication techniques including the use of Samsungs new Gen 7 line. Many of these technologies will be applied to other products within Samsungs LCD-TV product line. Samsungs broader development efforts toward the overall LCD-TV market, including production status of the Gen 7 facility, will be updated.

43.3: Distinguished Paper: An Advanced Intra‐Panel Interface (AiPi) with Clock Embedded Multi‐Level Point‐to‐Point Differential Signaling for Large‐Sized TFT‐LCD Applications

In this paper, we present the newly developed intra-panel interface targeting to replace conventional multi-drop bus architecture with point-to-point differential interface. The multi-level signaling scheme is adopted to remove separate clock and control signal lines by embedding clock information into multi-level signal. The clock embedding scheme removes the skew problem found in previously announced intra-panel interface, and provides lower EMI. The simple multi-level signal detector is used to regenerate the clock signal from the data stream and does not require any sophisticated clock recovery unit in the receiver. The AiPi can be an effective solution to large size TFT LCD applications due to the reduced signal lines, lower EMI, and lower power consumption.

Comparison of Image Enhancement Methods for the Effective Diagnosis in Successive Whole-Body Bone Scans

Whole-body bone scan is one of the most frequent diagnostic procedures in nuclear medicine. Especially, it plays a significant role in important procedures such as the diagnosis of osseous metastasis and evaluation of osseous tumor response to chemotherapy and radiation therapy. It can also be used to monitor the possibility of any recurrence of the tumor. However, it is a very time-consuming effort for radiologists to quantify subtle interval changes between successive whole-body bone scans because of many variations such as intensity, geometry, and morphology. In this paper, we present the most effective method of image enhancement based on histograms, which may assist radiologists in interpreting successive whole-body bone scans effectively. Forty-eight successive whole-body bone scans from 10 patients were obtained and evaluated using six methods of image enhancement based on histograms: histogram equalization, brightness-preserving bi-histogram equalization, contrast-limited adaptive histogram equalization, end-in search, histogram matching, and exact histogram matching (EHM). Comparison of the results of the different methods was made using three similarity measures peak signal-to-noise ratio, histogram intersection, and structural similarity. Image enhancement of successive bone scans using EHM showed the best results out of the six methods measured for all similarity measures. EHM is the best method of image enhancement based on histograms for diagnosing successive whole-body bone scans. The method for successive whole-body bone scans has the potential to greatly assist radiologists quantify interval changes more accurately and quickly by compensating for the variable nature of intensity information. Consequently, it can improve radiologists’ diagnostic accuracy as well as reduce reading time for detecting interval changes.