Tae Won Kang

2-Chloro-4,6-dimethoxy-1,3,5-triazine: A New Effective and Convenient Coupling Reagent for Cephalosporin Derivatives

Abstract Chloro-4,6-dimethoxy-1,3,5-triazine(CDMT) 2 was reacted with 2-(2-amino-4-thiazolyl)-2-syn-alkoxyiminoacetic acid 1 to give an active ester intermediate 3.

A Mild and Efficient Tetrahydropyranylation of Alcohols

Abstract Triphenylphosphine (TPP)-iodotrimethylsilane (TMSI) was found to be a convenient and highly effective catalyst for the tetrahydropyranylation of aliphatic and aromatic alcohols with dihydropyran in dichloromethane at ambient temperature.

A Facile Removal of P-Methoxybenzyl and Diphenylmethyl Ester with Iodotrimethyl-Silane-Triphenylphosphine

Abstract Diphenylmethyl (DPM) and p-methoxybenzyl (PMB) ester of cephalosporin derivatives were converted to the corresponding carboxylic acid using iodotrimethylsilane (TMSI)-triphenylphosphine (TPP) in dichloromethane at room temperature in good yields.

Diethyl Chlorophosphate: An Effective and Convenient Coupling Reagent of Cephalosporin Derivatives

Abstract A coupling reagent, diethyl chlorophosphate (DECP) 2, was reacted with 2-(2-amino-4-thiazolyl)-2-syn-alkoxyiminoacetic acid 1 to give an active ester intermediate 3.

Preparation Of Ceph-3-Em Esters Unaccompanied By δ3 To δ2 Isomerization Of The Cephalosporin Derivatives

Abstract A synthesis of cephalosporin derivatives by reacting cephalosporin free carboxylic acid with alkyl halide in the presence of cesium carbonate and potassium carbonate is disclosed. δ3 to δ2 isomerization, a side reaction commonly reported in preparation of cephalosporin derivatives, was successfully eliminated The desired δ3 was obtained as a sloe product in the reaction.

N,N'-Diisopropyl-O-Diphenylmethyl Isourea: A Mild and Convenient Alkylating Agent for the Formation of Cephalosporin Derivatives

Abstract N,N-Diisopropyl-O-diphenylmethyl isourea reacts with cephalosporin-4-carboxylic acid in tetrahydrofuran at room temperature to give the diphenylmethyl (DPM) ester in good yields without isomerization of the double bond from C-3 to C-2.