Taewan Kim
Andong National University
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Featured researches published by Taewan Kim.
International Immunopharmacology | 2010
Da-Hye Jung; Hyejin Park; Hye-Eun Byun; Yoon-Moon Park; Taewan Kim; Byung-Oh Kim; Sung Hee Um; Suhkneung Pyo
Diosgenin is a precursor of steroid hormones, which can be found in several plant species. Diosgenin has been shown to have a variety of biological activities including anti-inflammatory activity, but through a mechanism that is unclear. Especially, the effect of this agent on macrophage function has not been characterized in detail. In the present study, we examined the effects of diosgenin on the production of inflammatory mediators in lipopolysaccharide (LPS)/interferon gamma (IFN-gamma)-activated murine macrophage. Macrophages pre-exposed to diosgenin (0.1-10 microM) were stimulated with LPS/IFN-gamma. Pretreatment with diosgenin resulted in the inhibition of NO production and inducible nitric oxide synthase (iNOS) protein and mRNA expression in a concentration-dependent manner. In addition, diosgenin inhibits production of reactive oxygen species (ROS), interleukin-1 (IL-1), and IL-6, but not that of tumor necrosis factor-alpha (TNF-alpha). Inhibition of these inflammatory mediators appears to be at the transcriptional level, since diosgenin decreased LPS/IFN-gamma-induced NF-kappaB and AP-1 activity. Diosgenin blocked CK2 activation and phosphorylation of c-Jun NH(2)-terminal kinase (JNK), but not that of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase 1/2 (ERK 1/2). These results indicate that the inhibition of these signaling molecules expression was correlated with the reduced production of inflammatory mediators in macrophages. Taken together the present data suggest that diosgenin reduces the production of inflammatory meditators by inhibiting LPS/IFN-gamma-triggered CK2, JNK, NF-kappaB and AP-1 activation, thereby implicating a mechanism by which diosgenin may exert its immunosuppressive effects.
Vascular Pharmacology | 2010
Ko-Woon Choi; Hyejin Park; Da Hye Jung; Taewan Kim; Yoon-Moon Park; Byung-Oh Kim; Eun-Hwa Sohn; Eun-Yi Moon; Sung Hee Um; Dong-Kwon Rhee; Suhkneung Pyo
Atherosclerosis is a chronic inflammatory disease and the expression of adhesion molecules on vascular smooth muscle cells (VSMCs) contributes to the progress of the disease. Diosgenin, a precursor of steroid hormones, has been shown to have a variety of biological activities including anti-inflammatory activity; however, its molecular mechanisms are poorly understood. This study examined the effect of diosgenin on the expression of adhesion molecules induced by TNF-α in cultured mouse VSMC cell line, MOVAS-1. Preincubation of VSMCs for 2h with diosgenin (0.1-10 μM) dose-dependently inhibited TNF-α-induced adhesion of THP-1 monocytic cells and mRNA and protein expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1). Diosgenin abrogated TNF-α induced production of intracellular reactive oxygen species (ROS) and phosphorylation of p38, ERK, JNK and Akt. Diosgenin was also shown to inhibit NK-κB activation induced by TNF-α. Furthermore, diosgenin inhibited TNF-α-induced IκB kinase activation, subsequent degradation of IκBα, and nuclear translocation of NF-κB. Our results indicate that diosgenin inhibits the adhesive capacity of VSMC and the TNF-α-mediated induction of ICAM-1 and VCAM-1 in VSMC by inhibiting the MAPK/Akt/NF-κB signaling pathway and ROS production, which may explain the ability of diosgenin to suppress inflammation within the atherosclerotic lesion and modulate immune response.
Korean Journal of Food Preservation | 2009
Tae Hoon Kim; Seung-Ryeul Shin; Taewan Kim; In-Chul Lee; Moon-Young Park; Cheorun Jo
Korean Journal of Food Preservation | 2015
Eun-Woo Lee; Taewan Kim; Hyun-Seok Kim; Youn-Moon Park; Seong-Ho Kim; Moo-Hyeog Im; Jae Hoon Kwak; Tae Hoon Kim
Korean Journal of Horticultural Science & Technology | 2015
Yoon-Moon Park; Taewan Kim; Hyun-Seok Kim; Tae Hoon Kim; Yoo Jin Park
한국식품영양과학회 산업심포지움발표집 | 2014
Jin-Young Kim; Sha Li; Myoung Chul Yoon; Yong-Xiang Wu; Youn-Moon Park; Hyun-Seok Kim; Taewan Kim
한국식품영양과학회 산업심포지움발표집 | 2014
Sung-il Cho; Jin me Yoon; Sha Li; Jin-Young Kim; Yong-Xiang Wu; Youn-Moon Park; Hyun-Seok Kim; Taewan Kim
한국식품영양과학회 산업심포지움발표집 | 2014
Jin me Yoon; Sung-il Cho; Sha Li; Yong-Xiang Wu; Taewan Kim
한국식품영양과학회 산업심포지움발표집 | 2014
Sha Li; Jin-Young Kim; Sung-il Cho; Myung-Chul Yun; Jin me Yoon; Yong-Xiang Wu; Taewan Kim
한국식품영양과학회 산업심포지움발표집 | 2014
Myung Chul Yun; Yong-Xiang Wu; Sha Li; Jin-young Kim; Taewan Kim