Taichi Ohmoto

Pollen morphology of andruris japonica (triuridaceae)

Abstract Pollen morphology of Andruris japonica (Triuridaceae) was investigated by light and electron microscopy. The pollen is monosulcate and has a size of 22–25 μm × 25–28 μm in polar view. In the non-apertural region the exine has gemmate to nearly verrucate protrusions of 0.4–0.5 μm in diameter and 0.3–0.5 μm in height, and a foot layer of 0.4–0.5 μm in thickness. The sporoderm of the apertural region has large gemmae of 0.7–0.8 μm in diameter and 0.6–0.7 μm in height, with a thin foot layer of 0.1 μm thickness.

QSAR Studies of Picrodendrins and Related Terpenoids — Structural Differences Between Antagonist Binding Sites on GABA Receptors of Insects and Mammals

γ -Aminobutyric acid (GABA), an inhibitory neurotransmitter, binds to the GABAA (ionotropic) receptor, to regulate the central nervous system of vertebrates. Insects have similar ionotropic receptors with different pharmacological properties, and, as a result, their GABA receptors represent promising targets for insecticides. Recently, 3D-QSAR analyses for insecticidal activity (against houseflies) and competitive activity against the specific [35S]tert-butylbicyclophosphorothionate (TBPS) binding (to rat brain membranes) of some picrotoxinin-type GABA antagonists, including γ -BHC, endosulfan, bicyclophophates, dioxatricyclododecenes (DTD) and related compounds, were carried out1 using comparative molecular field analysis (CoMFA). The CoMFA results showed that similarities and dissimilarities in sterically and electrostatically favourable and forbidden regions on the molecule were reflected in the insecticidal and rat-receptor binding activities.

酵素阻害活性による漢方処方の検討(第4報)Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesteraseによる鉱物性生薬配合処方の研究

Twenty five Chinese herbal medicinal prescriptions containing gypsum, kaolin, longgu, oyster shell and sodium sulfate were studied for the inhibitory activity of adenosine 3,5-cyclic monophosphate phosphodiesterase. The inhibitory activity of 15 prescriptions without mineral drug was higher than that of each original prescription. On the contrary, four were lower and six were not recognized to be different. All 11 prescriptions containing gypsum with an exception increased the inhibitory activity by removing gypsum. The half prescriptions containing kaolin or sodium sulfate also increased the inhibitory activity by removing the drug.