Takaaki Ohmori

CA125-PRODUCING ADENOCARCINOMA OF THE SEMINAL VESICLE

A case of primary seminal vesicle carcinoma is reported. The tumor was a CA125‐producing adenocarcinoma consisting of fine papillary‐tubular, intricate branching or anastomosing glandular structures and was composed of small cuboidal, but occasionally hobnailed, cells with mostly clear, but occasionally granular, cytoplasm. Some tumor cells showed evidence of secretion of seromucinous materials into the interpapillary and cystic space. lmmunohistochemically, almost half of the tumor cells expressed a positive reaction with anti‐CAl25, a common serological marker for ovarian epithelial carcinomas; however, no tumor cells expressed any other serological tumor markers such as carcinoem‐bryonic antigen, α‐fetoprotein, human chorionic gonadotropin, prostatic specific acid phosphatase, or prostatic specific antigen. The patient showed a high level of serological CA125, which fluctuated parallel with the growth, removal and recurrence of the tumor. The morphological and immunohistochemical findings suggested a close relationship between the present tumor and clear cell carcinoma of the ovary, which is thought to be of a Müllerian‐Wolfian duct origin.

Giant hepatic angiomyolipoma.

phoma of the heart in two patients with the acquired immunodeficiency syndrome. Arch. Parhol. Lab. Meti. 1987; 111; 254 256. HAMBLEN AS. In: Lynlpphokines. Oxford: IRI. Press, 1988. J A V l E R BU. Y A U N T W J , CROSBY D T . H A L L T C . Cardiac metastases in lymphoma and leukaemia. 06. Chrsl 1967; 52; 481-484. MCALLISTCK H A , FENOGLIO J J . A r l m o/ ~ U ~ ~ Z O Y Pur/iolo,y.y, Tumours of the cardiovascular system. 2nd series, fasicle 15. Washington, DC: Armed Forces Institute of Pathology, 1978. ROBINSON FC. Aneurysms of the coronary arteries. Am. Hmi-I J . 1985; 109; 129 135. ROH LS. PAPARO GP. Primary malignant lymphoma of the heart in sudden unexpected death. J . Forensic Sciences 1982: 27; 718-722.

MALIGNANT GRANULAR CELL TUMOR OF THE ESOPHAGUS

Malignant granular cell tumor of the esophagus found in a 70‐year‐old female was reported. Microscopically, the tumor showed a variety of the histology from compact proliferation of polygonal granular cells in pseudo‐epitheliomatous pattern to plexiform proliferation of elongated granular and fibroblastic cells in neuroflbromatous pattern, and the tumor cells frequently contained eosinophilic globules in the cytoplasm. Histochemically, argyrophilic neurofibrils in the stroma and argyrophilic cytoplasmic processes or grains were seen. Immunohistochemically, the tumor cells showed positive reaction with S–100 protein (S–100), but all reactions with myoglobin (MG), desmin (DM), fibronectin (FN), creatinine phosphokinase–mm (CPK), factor gthrelated antigen (F8RA), alpha–1–antitrypsin (AIAT), alpha–1–anti–chymotrypsin (AIACT), keratin (KN), and carcinoembryonic antigen (CEA) were negative. Electron microscopy revealed that the tumor cells had typical lysosomal granules filled with proteinaceous electron dense materials and fine membrane‐bound particles sized 15 to 45 nm resembling virus or neurosecretory granule.

Pericardial malignant mesothelioma: Case report and discussion of immunohistochemical and histochemical findings

An extremely rare case of malignant mesothelioma of the pdcardium is reported. The tumor appeared to be the Uphasic type of diffuse malignant mesothetioma which presgnt many small to tine lipid droplets in the cytoplasm, particularly that of the epithelial cell, and a positive immunohistochemical reaction with antibodies to low molecular weight cytokeratin (45–50 kDa) in all of the tumor cells. The literature is also reviewed and the presence of lipid droplets and the importance of the immunohistochemical positivity to low molecular weight cytokeratin for differential diagnosis from other malignant tumors, such as invasive adeno‐carcinoma or primary sarcoma of the pleura, or soft tissue sarcoma involving the pleura is discussed.

Solitary plasmacytoma of the submandibular lymph node with stromal amyloid deposits.

This report concerns a case of solitary extramedullary plasmacytoma of the left submandibular lymph node in a 56‐year‐old man. The tumor showed monoclonal proliferation of abnormal plasma cells which revealed highly positive stainings of both methylgreen pyronin and kappa light chain using the immunoperoxidase technique in the cytoplasms, and further revealed massive‘.amyloid’deposits in the stroma, which suggested the possibility of sequential amyloid formation upon the secretion of paraprotein by tumor cells.

Sclerosing encapsulating peritonitis and non-occlusive mesenteric infarction found at autopsy in a man who had undergone continuous ambulatory peritoneal dialysis: a histochemical and immunohistochemical study.

This is a report of a post‐mortem histological, histochemical, and immunohistochemical examination of a rare case of sclerosing encapsulating peritonitis (SEP) and non‐occlusive mesenteric infarction (NOMI), two serious complications of continuous ambulatory peritoneal dialysis (CAPD), with which a man suffering hepatitis C virus (HCV)‐induced liver cirrhosis for 7 years and trauma‐induced paraplegia for 50 years had been treated for 1 year. The direct cause of death was encephalopathy caused by extreme hyperammonemia (11 250 μg/dL in serum). The autopsy revealed that the SEP had drastically reduced the length of the small intestine to 210 cm, 180 cm of which presented acute ischemic enteritis with Gram‐negative bacterial infection. Histological examination of the SEP revealed that the exterior was composed of normal serosal elastic lamina, but with a cocoon‐like appearance remarkably thickened by fibrosis to 3–8 times that of the normal subserosal layer and consisting of spindle cells and blood vessels, with some infiltration of mast cells and lymphocytes. The immunohistochemical examination of the spindle cells revealed few AE1/AE3(+) cells, HHF35(+) cells, and CD34(+) cells, many CD117(+) cells with slight proliferative activity based on MIB‐1 positivity (proliferation index <1%), but no CD44(+) cells. It was concluded that either the few CD34(+) and/or the many CD117(+) cells were mesenteric stem cells that had originated from the serosa, proliferated, then differentiated into myofibroblasts or fibroblasts, producing collagen and hyaluronic acid in the matrix, leading to the gradual formation of the SEP, which was induced by the continual irritation of CAPD.

MALIGNANT FIBROUS HISTIOCYTOMA SHOWING CYTOPLASMIC HYALINE GLOBULES AND STROMAL OSTEOIDS: A Case Report with Light and Electron Microscopic, Histochemical, and Immunohistochemical Study

A 56‐year‐old man died of widespread metastases of malignant fibrous histiocytoma (MFH) primarily developed in the left lower gingiva after a rapid clinical course is reported. Primary and metastatic tumors showed light and electron microscopic, histochemical and immunohistochemical characteristics of MFH together with cytoplasmic hyaline globules and stromal osteoids. Hyaline globules revealed periodic acid‐Schiff positive and diastase resistant reactions but not positive with any histochemical and immunohistochemical reactions. Osteoids were partially calcified and rimmed by osteoblastic tumor cells. The present case of MFH may provide difficulties in the differential diagnosis from some osteoid‐forming sarcomas in soft tissues with relation to the histogenesis.

Low susceptibility of specific inbred colonies of rats to nickel tumorigenesis in soft tissue

Nickel sarcomatogenesis induced by a single intramuscular injection of 10 mg of nickel subsulfide (NiSS) into the soft tissue of two different colonies of Wistar rats was studied. In spontaneously hypertensive rats (SHR), a specific inbred colony of rats derived from a certain Wistar strain, the sarcoma induction rate was lower than that in common closed colony rats of the same strain (CWR). Sarcomas were induced in only 7 of the 30 rats (23.3%) in the SHR group (15 female and 15 male) but in 21 of the 31 rats (67.7%) in the CWR group (15 female and 16 male) (P < 0.005). The incidence of sarcoma induction was lower in female rats than in male rats in both the SHR (female 13.3% < male 33.3%) and CWR (female 53.3% < male 81.4%) groups. Primary tumors in the SHR group exhibited a lower grade of metastasis to lymph nodes (P < 0.001) and lungs (P < 0.05) than in the CWR group. Our study demonstrated that rats in a certain specific inbred colony are less susceptible to nickel tumorigenesis in soft tissue than rats in a common closed colony.

A fatal case of fungal endocarditis of the tricuspid valve associated with long-term venous catheterization and treatment with antibiotics in a patient with a history of alcohol abuse

We report a fatal case of fungal (candidal) endocarditis of the tricuspid valve with clinico-pathologically interesting findings following and associated with candidal pneumonia during long-term central venous catheterization (CVC) for intravenous therapy and long-term treatment with antibiotics for bacterial and fungal infection in a patient with a history of alcohol abuse. We review the literature on fungal cardiac infection related to long-term catheterization and alcohol abuse, and discuss the pathogenesis.

Adenoendocrine cell carcinoma of the gallbladder: A histochemical and immunohistochemical study

A case of adenoendocrine cell carcinoma of the gallbladder with adenomucous cells and neuroendocrine cells is report‐ ed. A histochemical and immunohistochemical study revealed that the primary tumor in the gallbladder was composed of mucus‐secreting and/or argyrophil cells. Furthermore, the tumor showed a positive reaction to carcinoembryonic antigen (CEA) in all tumor cells, to chromogranin A and cytokeratin in many tumor cells, to endocrine granule constituent (EGC) in some tumor cells, and to serotonin and somatostatin in a few tumor cells. In addition, a few mucous cells showed argyrophilia and EGC‐positivity in their cytoplasms. This case suggests that the adenoendocrine cell tumor is derived from endodermal stem cells as a result of bidirectional (exocrine and endocrine) differentiation.