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Takaaki Okita

Bristol-Myers Squibb

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Publication

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Journal of Natural Products | 2009

Lorneic Acids, Trialkyl-Substituted Aromatic Acids from a Marine-Derived Actinomycete

Fumie Iwata; Seizo Sato; Takako Mukai; Shoichi Yamada; Jiro Takeo; Akihisa Abe; Takaaki Okita; Hiroyuki Kawahara

A marine-derived actinomyces strain (NPS554) isolated from a marine sediment sample collected from Miyazaki Harbor, Japan, at a depth of 38 m yielded two trialkyl-substituted aromatic acids, lorneic acid A (1) and lorneic acid B (2). The structures of the lorneic acids, which were elucidated by spectroscopic analysis, differed only in the side-chain, which contained either a conjugated double bond or a benzylic alcohol. Their structural differences affected inhibition activities against phosphodiesterase 5.

The Journal of Antibiotics | 1980

Bu-2313, a new antibiotic complex active against anaerobes. II. Structure determination of Bu-2313 A and B.

Mitsuaki Tsunakawa; Soichiro Toda; Takaaki Okita; Minoru Hanada; Susumu Nakagawa; Hiroshi Tsukiura; Takayuki Naito; Hiroshi Kawaguchi

The Journal of Antibiotics | 1991

SYNTHESIS, STEREOCHEMISTRY, AND BIOLOGICAL PROPERTIES OF THE DEPIGMENTING AGENTS, MELANOSTATIN, FELDAMYCIN AND ANALOGS

Kiyoto Imae; Hajime Kamachi; Haruhiro Yamashita; Takaaki Okita; Satsuki Okuyama; Takashi Tsuno; Tetsuro Yamasaki; Yosuke Sawada; Masaru Ohbayashi; Takayuki Naito; Toshikazu Oki

The Journal of Antibiotics | 1988

SYNTHESIS AND BIOLOGICAL ACTIVITY OF A NEW CEPHALOSPORIN, BMY-28232 AND ITS PRODRUG-TYPE ESTERS FOR ORAL USE

Hajime Kamachi; Yukio Narita; Takaaki Okita; Yoshio Abe; Seiji Iimura; Kozo Tomatsu; Tetsuro Yamasaki; Jun Okumura; Takayuki Naito; Toshikazu Oki; Hiroshi Kawaguchi

Archive | 1990

Antibiotic C-7 catechol-substituted cephalosporin compounds, compositions, and method of use thereof

Takaaki Okita; Hajime Kamachi; Shinji Masuyoshi; Kiyoto Imae

Chemical & Pharmaceutical Bulletin | 1982

Synthesis and Bronchodilating Activity of 2, 9-Disubstituted Adenine Derivatives : BB-1502 (9-Cyclohexyl-2-n-propoxy-9H-adenine) and Its Analogs

Takayuki Naito; Susumu Nakagawa; Takaaki Okita; Haruhiro Yamashita; Tetsuro Yamasaki; Hideo Kamei; Kozo Tomatsu; Hideyo Imanishi; Hiroshi Kawaguchi

Chemical & Pharmaceutical Bulletin | 1998

Synthesis and Structure-Activity Relationships of Phaffiaol and Related Antioxidants.

Shuji Jinno; Takaaki Okita

The Journal of Antibiotics | 1993

SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF CEPHALOSPORINS HAVING A CATECHOL IN THE C3 SIDE CHAIN

Takaaki Okita; Kiyoto Imae; Toshifumi Hasegawa; Seiji Iimura; Shinji Masuyoshi; Hajime Kamachi; Hideo Kamei

Archive | 1979

Purine derivatives and their use as bronchodilators

Takayuki Naito; Susumu Nakagawa; Tetsuro Yamasaki; Takaaki Okita; Haruhiro Yamashita

Heterocycles | 1999

Synthesis of an Antioxidant Having a Dibenz[b,f]oxepine Skeleton

Shuji Jinno; Takaaki Okita

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Hajime Kamachi

Bristol-Myers Squibb

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Shuji Jinno

Osaka University

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Takayuki Naito

Bristol-Myers Squibb

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Satsuki Okuyama

Bristol-Myers Squibb

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Haruhiro Yamashita

Bristol-Myers Squibb

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Susumu Nakagawa

Bristol-Myers Squibb

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Shinya Yamashita

Kitasato University

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Takayuki Naito

Bristol-Myers Squibb

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Kiyoto Imae

Bristol-Myers Squibb

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Tetsuro Yamasaki

Bristol-Myers Squibb

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