Takahiko Yoshimoto

Pulmonary alveolar proteinosis: Analysis of pulmonary washings

Bronchopulmonary washings from a patient with pulmonary alveolar proteinosis who underwent therapeutic pulmonary lavage were examined. There were large amounts of protein and lipids of which main classes were phospholipid, cholesterol and free fatty acid. The major component of phospholipids recovered from the washings was lecithin rich in palmitic acid. We also found a high IgG level in the washings. Both the findings of free cholesterol in high concentration in the washings and the electrophoretic pattern of protein in the washings suggested that the alveoli-filling material of our patient was not wholely derived from passive transudation of plasma constituents.

Effect of Nocardia rubra cell-wall skeleton treatment on tumor formation in two-stage chemical carcinogenesis of mouse skin

SummaryIn two-stage chemical carcinogenesis of mouse skin, Nocardia rubra cell-wall skeleton (N-CWS), a potent immunopotentiator, was injected SC at various times. The dorsal skin of C57BL/6 male mice (about 10 cm2) was painted with 20 μg 7,12-dimethylbenz(a)anthracene (DMBA) in 0.1 ml acetone when the animals were 11 weeks old (initiation). Seven weeks later, they were painted with 2.5 μg 12-0-tetradecanoyl-phorbol-13-acetate (TPA) in 0.1 ml acetone twice weekly for 30 weeks (promotion). The timing of N-CWS treatment was important. N-CWS treatment before initiation reduced the incidence of skin tumor and the mean number of skin tumors per mouse most effectively. It is speculated that the antitumor activity of N-CWS may be composed of at least two mechanisms, being achieved through the enhancement of immunological surveillance and through changes in the metabolism of chemical carcinogens.

A case of small cell carcinoma of the lung with metastasis to the stomach.

胃転移が生前に発見され, 化学療法により一度完全寛解した肺小細胞癌の1例を報告する.症例は64才男性, 胸痛, 咳, 血疾を主訴に来院した.胸部X線写真にて右肺門部に腫瘤影があり, 喀痰細胞診, 気管支鏡下生検にて小細胞癌と診断された.便潛血反応が陽性で, 進行性の貧血があり, 上部消化管透視を行った所, 胃腫瘍が発見された.胃内視鏡下生検にて小細胞癌と診断された.化学療法により胃転移は消失し, 2年2ヶ月生存した.