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Dive into the research topics where Takahiro Higuchi is active.

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Featured researches published by Takahiro Higuchi.


International Journal of Cardiology | 2016

Assessment of coronary flow reserve using a combination of planar first-pass angiography and myocardial SPECT: Comparison with myocardial 15O-water PET

Naoko Nose; Kazuhito Fukushima; Constantin Lapa; Rudolf A. Werner; Mehrbod S. Javadi; Junichi Taki; Takahiro Higuchi

UNLABELLEDnCoronary flow reserve (CFR), defined as the ratio of maximum coronary flow increase from baseline resting blood flow, is one of the most sensitive parameters to detect early signs of coronary arteriosclerosis at the microvascular level. Myocardial perfusion PET is a well-established technology for CFR measurement, however, availability is still limited. The aim of this study is to introduce and validate myocardial flow reserve measurement by myocardial perfusion SPECT.nnnMETHODSnMyocardial perfusion SPECT at rest and ATP stress (0.16mg/Kg/min) was performed in 10 patients with known coronary artery disease. Immediately after the injection of Tc-99m sestamibi (MIBI), left ventricular (LV) dynamic planar angiographic data were obtained for 90s. Coronary flow reserve index as measured by MIBI SPECT (CFRMIBI) was calculated as follows: CFRMIBI=CmsSbmb/CmbSbms, where subscripts b, s, Cm, and Sbm indicate baseline, during stress, myocardial counts with MIBI SPECT, and integral of LV counts with first pass angiography, respectively. Additionally, standard stress/rest (15)O-water PET to estimate CFR was performed in all patients as standard of reference.nnnRESULTSnCFRMIBI increased in conjunction with CFR, but underestimated blood flow at high flow rates. The relationship between CFRMIBI (Y) and CFRPET (X) was well fitted as follows: Y=1.40x(1-exp(1.79/x)) (r=0.84).nnnCONCLUSIONSnThe index of CFRMIBI reflects the CFR by (15)O-water PET but underestimates flow at high flows, maybe as a reflection of pharmacokinetic limitations of MIBI.


Society of Nuclear Medicine Annual Meeting Abstracts | 2012

F-18 labeled PET tracer LMI1195 for imaging norepinephrine handling in rat hearts

Takahiro Higuchi; Behrooz H. Yousefi; Sybille Reder; Christoph Rischpler; Eliane Weidl; Ming Yu; Simon P. Robinson; Markus Schwaiger; Stephan Nekolla


Society of Nuclear Medicine Annual Meeting Abstracts | 2009

Task-based human observer study for evaluation and optimization of 3D & 4D image reconstruction methods for gated myocardial perfusion SPECT

Taek-Soo Lee; Riikka Lautamäki; Takahiro Higuchi; Frank Bengel; Benjamin Tsui


Society of Nuclear Medicine Annual Meeting Abstracts | 2010

Use of the AT1R ligand C-11 KR31173 for monitoring of the myocardial effect of drugs inhibiting the renin-angiotensin system after myocardial infarction

Takahiro Higuchi; Kenji Fukushima; Jinsong Xia; Riikka Lautamäki; James Fox; William B. Mathews; Zsolt Szabo; Frank Bengel


Annals of Nuclear Cardiology | 2018

A New Era of Myocardial Perfusion Imaging: 18 F PET Tracer

Mitsuru Hirano; Rudolf A. Werner; Takahiro Higuchi


Society of Nuclear Medicine Annual Meeting Abstracts | 2010

Myocardial angiotensin II subtype 1 receptor (AT1R) imaging using PET-CT with 11C-KR31173 - A translational effort in the porcine model

Kenji Fukushima; Takahiro Higuchi; Anthony DiPaula; Karl H. Schuleri; John Hilton; William B. Mathews; Robert F. Dannals; Zsolt Szabo; Albert Lardo; Frank Bengel


Society of Nuclear Medicine Annual Meeting Abstracts | 2009

Assessment of regional myocardial angiotensin II receptor upregulation after myocardial infarction by PET

Takahiro Higuchi; Kenji Fukushima; Jinsong Xia; Riikka Lautamäki; James Fox; William B. Mathews; Zsolt Szabo; Frank Bengel


4th Theranostics World Congress | 2016

68Ga-Pentixafor-PET/CT for Imaging of Chemokine Receptor 4 Expression in Neuroendocrine Tumors - a head-to-head comparison with DOTATOC and FDG PET/CT

Michael Lassmann; Rudolf A. Werner; Alexander Weich; Hans-Juergen Wester; Michael Scheurlen; Takahiro Higuchi; Samuel Samnick; Christina Bluemel; Martina Rudelius; Andreas K. Buck; Constantin Lapa; Ken Herrmann


Society of Nuclear Medicine Annual Meeting Abstracts | 2014

Damage to and restoration of cardiac sympathetic nerve system after transient ischemia in rat hearts

Constantin Lapa; Tomohiko Yamane; Min-Jae Park; Rudolf A. Werner; Mehrbod S. Javadi; Takahiro Higuchi


Society of Nuclear Medicine Annual Meeting Abstracts | 2013

Myocardial kinetics of novel F-18 sympathetic nerve tracer LMI1195 in the isolated working rabbit heart

Takahiro Higuchi; Behrooz H. Yousefi; Sybille Reder; Monika Beschorner; Florian Gaertner; Christoph Rischpler; Ming Yu; Simon P. Robinson; Markus Schwaiger; Stephan Nekolla

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Mehrbod S. Javadi

Johns Hopkins University School of Medicine

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Rudolf A. Werner

Johns Hopkins University School of Medicine

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Hiroyuki Tsuchiya

Kyoto Pharmaceutical University

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Paco E. Bravo

Johns Hopkins University

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