Takahiro Higuchi
Hyogo College of Medicine
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International Journal of Cardiology | 2016
Naoko Nose; Kazuhito Fukushima; Constantin Lapa; Rudolf A. Werner; Mehrbod S. Javadi; Junichi Taki; Takahiro Higuchi
UNLABELLEDnCoronary flow reserve (CFR), defined as the ratio of maximum coronary flow increase from baseline resting blood flow, is one of the most sensitive parameters to detect early signs of coronary arteriosclerosis at the microvascular level. Myocardial perfusion PET is a well-established technology for CFR measurement, however, availability is still limited. The aim of this study is to introduce and validate myocardial flow reserve measurement by myocardial perfusion SPECT.nnnMETHODSnMyocardial perfusion SPECT at rest and ATP stress (0.16mg/Kg/min) was performed in 10 patients with known coronary artery disease. Immediately after the injection of Tc-99m sestamibi (MIBI), left ventricular (LV) dynamic planar angiographic data were obtained for 90s. Coronary flow reserve index as measured by MIBI SPECT (CFRMIBI) was calculated as follows: CFRMIBI=CmsSbmb/CmbSbms, where subscripts b, s, Cm, and Sbm indicate baseline, during stress, myocardial counts with MIBI SPECT, and integral of LV counts with first pass angiography, respectively. Additionally, standard stress/rest (15)O-water PET to estimate CFR was performed in all patients as standard of reference.nnnRESULTSnCFRMIBI increased in conjunction with CFR, but underestimated blood flow at high flow rates. The relationship between CFRMIBI (Y) and CFRPET (X) was well fitted as follows: Y=1.40x(1-exp(1.79/x)) (r=0.84).nnnCONCLUSIONSnThe index of CFRMIBI reflects the CFR by (15)O-water PET but underestimates flow at high flows, maybe as a reflection of pharmacokinetic limitations of MIBI.
Society of Nuclear Medicine Annual Meeting Abstracts | 2012
Takahiro Higuchi; Behrooz H. Yousefi; Sybille Reder; Christoph Rischpler; Eliane Weidl; Ming Yu; Simon P. Robinson; Markus Schwaiger; Stephan Nekolla
Society of Nuclear Medicine Annual Meeting Abstracts | 2009
Taek-Soo Lee; Riikka Lautamäki; Takahiro Higuchi; Frank Bengel; Benjamin Tsui
Society of Nuclear Medicine Annual Meeting Abstracts | 2010
Takahiro Higuchi; Kenji Fukushima; Jinsong Xia; Riikka Lautamäki; James Fox; William B. Mathews; Zsolt Szabo; Frank Bengel
Annals of Nuclear Cardiology | 2018
Mitsuru Hirano; Rudolf A. Werner; Takahiro Higuchi
Society of Nuclear Medicine Annual Meeting Abstracts | 2010
Kenji Fukushima; Takahiro Higuchi; Anthony DiPaula; Karl H. Schuleri; John Hilton; William B. Mathews; Robert F. Dannals; Zsolt Szabo; Albert Lardo; Frank Bengel
Society of Nuclear Medicine Annual Meeting Abstracts | 2009
Takahiro Higuchi; Kenji Fukushima; Jinsong Xia; Riikka Lautamäki; James Fox; William B. Mathews; Zsolt Szabo; Frank Bengel
4th Theranostics World Congress | 2016
Michael Lassmann; Rudolf A. Werner; Alexander Weich; Hans-Juergen Wester; Michael Scheurlen; Takahiro Higuchi; Samuel Samnick; Christina Bluemel; Martina Rudelius; Andreas K. Buck; Constantin Lapa; Ken Herrmann
Society of Nuclear Medicine Annual Meeting Abstracts | 2014
Constantin Lapa; Tomohiko Yamane; Min-Jae Park; Rudolf A. Werner; Mehrbod S. Javadi; Takahiro Higuchi
Society of Nuclear Medicine Annual Meeting Abstracts | 2013
Takahiro Higuchi; Behrooz H. Yousefi; Sybille Reder; Monika Beschorner; Florian Gaertner; Christoph Rischpler; Ming Yu; Simon P. Robinson; Markus Schwaiger; Stephan Nekolla