Takamasa Iimori

Creation of novel chiral synthons with enzymes and applications to natural product synthesis. 15. Efficient introduction of chiral centers into cyclohexane ring

Abstract The chiral half-ester 2 obtained by asymmetric hydrolysis of the symmetric diester 1 with pig liver esterase has been shown to be a versatile synthon for various chiral cyclohexane derivatives.

Carbon-carbon bond formation from ethyl cyanoformate and active methylene compounds

Abstract A new methodology which leads to α,β-unsaturated α-amino acids has been developed through a carbon-carbon forming reaction using ethyl cyanoformate and active methylene compounds in the presence of zinc chloride and triethyl amine.