Takao Koike

BINDING OF BETA2‐GLYCOPROTEIN I TO PLATELET‐DERIVED MICROPARTICLES

Department of Haematology. Royal Free Hospital and School of Medicine, London NW3 2QG A. V. HOPFBRANU B. F. A. JACKSON the apo-enzyme and deficiency of the holo-enzyme due to a lack of the necessary 5.10-methylene tetrahydrofolate polyglutamate co-enzyme. 3 . The essence of the methyl-folate trap hypothesis, as we state in our paper, is not the pile-up of methyl-folate but starvation of tetrahydrofolate. The absence of a methyl-folate pile-up in patients with deficiency of 5,10-methylene reductase would not necessarily lead to starvation of tetrahydrofolate or formyl-tetrahydrofolate needed for folate polyglutamate synthesis and thus for folate coenzymes required in biochemical reactions in DNA synthesis. 4. The fact that patients with folate deficiency do not