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Publication
Featured researches published by Takao Nishimura.
Vox Sanguinis | 1989
Masaki Miyamoto; Shigeru Sasakawa; Yoshihide Ishikawa; Atsuko Ogawa; Takao Nishimura; Toru Kuroda
Abstract. We developed a new filter, ‘Sepacell‐PL’, consisting of a blood administraiton set for the preparation of leukocyte‐poor platelet concentrates at the patients bedside. This filter is packed with 1.8 μm polyester fibers coated with a new polymer, and has a volume of 14 ml. Sepacell‐PL removed more than 99% of the leukocytes while approximately 93% of platelets were recovered from 10 units of platelet concentrates which contained 5 times 108 leukocytes and 3 times 1011 platelets. The functions of pre‐ and postfiltrated platelets were unchanged. The filtration procedure is very simple, without priming with saline to remove air and wet the filter. Moreover, platelet concentrates can be passed through the filter at a flow rate of 4 ml/min, or at a higher flow rate of 54 ml/min by gravity.
Journal of the Japan Society of Blood Transfusion | 1992
Tsuneo A. Takahashi; Shin-Ichiroh Oka; Takao Nishimura; Mari Hosoda; Yuko Mogi; Hiroko Ohchi; Momoyo Nasu; Seiji Chiba; Naokuni Yamawaki; Sadayoshi Sekiguchi
The new high-performance R-S350 leukocyte removal filter was developed to deplete leukocytes from red cell concentrate and whole blood with high efficiency, that is, a higher than 4-log reduction. When 1 unit of red cell concentrate stored for 1 to 2 days was applied, the leukocytes were removed by 4.77 logs with 86.4% red cell recovery and the average filtration time was 15.5min. The average number of residual leukocytes was 4.56±6.74×104/unit (n=25). The R-5350 is also able to remove leukocytes from freshly drawn or 1-day-stored whole blood in a closed system. The leukocyte removal rate was 4.60 logs for fresh whole blood and 4.88 logs for blood stored for 1 day. Platelet removal rates were 2.4 to 2.8 logs and red cell recovery was about 90%. The filtration time was less than 15min for fresh whole blood. During storage of red cell concentrates prepared from filtered or nonfiltered whole blood for 3 weeks at 4°C, neither the ATP and 2, 3-DPG levels nor the morphological score of red cells significantly differed between the two types but the level of supernatant hemoglobin was less in the filtered red cell concentrates.A closed system with a leukocyte-removal filter has advantages for the extension of the storage period for more than 24 hours and keeps the cells in better physiological condition. The new R-5350 filter can be used in a closed system for leukocyte removal from whole blood before storage and is expected to be useful for the prevention of alloimmunization and other side effects of blood transfusion.
Archive | 1989
Toru Kuroda; Takao Nishimura
Archive | 1991
Shin-Ichiroh Oka; Takao Nishimura
Archive | 1994
Tatsuya Fukuda; Takao Nishimura; Naokuni Yamawaki
Archive | 1992
Tatsuya Fukuda; Takao Nishimura; Naokuni Yamawaki
Archive | 1995
Tatsuya Fukuda; Takao Nishimura; Naokuni Yamawaki
Archive | 1988
Toru Kuroda; Takao Nishimura
Archive | 1991
Shin-Ichiroh Oka; Takao Nishimura
Archive | 1989
Toru Kuroda; Takao Nishimura