Takasaki N

Surgical correction of buried penis after traffic accident – a case report

BackgroundBuried penis, most commonly seen in children, is particularly debilitating in adults, resulting in inability to void while standing and it also affects vaginal penetration. We report a case of buried penis due to a traffic accident, which caused dislocation of the fractured pubic bone that shifted inside and pulled the penis by its suspensory ligament.Case presentationA 55-year-old man was admitted to our hospital with a chief complaint of hidden penis while in the sitting position. He had suffered a pelvic fracture in a traffic accident four years previously, and his penis was covered with suprapubic fat when he was in a sitting position. He was unable to have sexual intercourse. We performed a penile lengthening procedure, including inverse V-Y-plasty of the dorsal skin of the penile root, suspensory desmotomy and fat removal, under general anesthesia. There was a good cosmetic result with satisfactory penile erection, which allowed successful sexual intercourse after surgery.ConculsionWe performed penile elongation surgery with inverse V-Y-plasty of the dorsal skin of the penile root, suspensory desmotomy, and fat removal. Surgical treatment of buried penis achieves marked aesthetic and functional improvement, and benefits the majority of patients, resulting in satisfactory erection and successful sexual intercourse.

Sensitization interval and administration method alter the effect of 15-deoxyspergualin on heart transplantation in sensitized recipient rats

We evaluated the effect of 15-deoxyspergualin (DSG) on accelerated rejection. Brown Norway rats (BN) served as organ donors and Lewis rats (LEW) as recipients. In an accelerated rejection model, after a LEW rat was sensitized with BN skin, a BN heart was transplanted. Various intervals between sensitization and heart transplantation were examined. The heart allografts in sensitized recipients were rejected earlier than those in unmodified recipients regardless of the sensitization interval. DSG (2.5 mg/kg per day), given to the recipients during the sensitization phase, significantly prolonged graft survival compared with the untreated hosts when the sensitization interval was short. When the recipients were treated with DSG after heart transplantation, heart graft survival was significantly prolonged regardless of the sensitization interval. Flow cytometric analysis and complement-dependent cytotoxicity tests revealed that DSG suppressed antidonor antibody formation and that postoperative administration of DSG significantly decreased the proliferation of B cells when the sensitization interval was short and the proliferation of class II antigen-positive cells when the sensitization interval was long.

Experimental studies on pathogenesis and progression of uremic neuropathy in rats

我々は, 尿毒症性末梢神経障害の病因および進展に及ぼす要因を検索する目的で, 慢性腎不全ラットの末梢神経内ミオイノシトール濃度, イノシトールリン脂質に取り込まれる32Pの比率を測定した.BUN, 血清クレアチニンは腎不全作製後1, 7, 20週とも対照に比し有意に高値を示し, 末梢神経伝導速度は有意に低下していた. 慢性腎不全ラットの血漿ではミオイノシトール濃度が対照に比し3-4倍の高値を示しているが, 坐骨神経内ミオイノシトール濃度は1週目1.76±1.23 (nmol/mg wet weight) (対照1.90±0.30), 7週目1.22±0.76 (1.63±0.76), 20週目0.52±0.42 (0.59±0.13) で, 対照との間に有意の差は認められなかった. また, イノシトールリン脂質やその他のリン脂質への32Pの取り込みの間に有意の差は認められなかった. 以上の結果より, 尿毒症性末梢神経障害の発症, 進展とイノシトールリン脂質代謝に関連性は認めず, 糖尿病性末梢神経障害の病因とは異なると考えられた.