Takayoshi Iyobe

The immunosuppressive effect of 5-lipoxygenase inhibitor on liver allotransplantation in rats

This study was performed to examine the immunosuppressive effect of a 5-lipoxygenase inhibitor, AA-861, on liver transplantation in rodents, and also to examine the production of eicosanoids during rejection of liver allograft in these animals. Rats were divided into three groups: group I (syngenic orthotopic liver transplantation from LEW to LEW), group II (allogenic OLT from ACI to LEW with dimethyl sulfoxide), and group III (allogenic OLT from ACI to LEW with AA-861 [20 mg/kg/day] s.c. dissolved in DMSO). Histological examinations were performed, survival time was monitored, and eicosanoid levels at 3, 5, and 7 days after transplantation were measured. Mean survival time in group III was significantly longer than that in group II (36.0 +/- 6.8 vs. 11.1 +/- 0.7 days, mean +/- SEM; P < 0.01). Histologically, the degree of rejection in group III was moderate compared with that in group II. On day 3, the LTB4 level in group II was significantly higher than that in group I (3361 +/- 985 vs. 407 +/- 70 pg/ml, P < 0.05), and the PGE2 level in group III was significantly higher than that in group 1 (50.3 +/- 4.8 vs. 23.5 +/- 4.7 pg/ml, P < 0.01) and in group II (32.9 +/- 4.2 pg/ml, P < 0.05). These findings suggest that AA-861 reduced liver allograft rejection by suppressing the elevation of 5-lipoxygenase products and increasing PGE2 production in the early stage of rejection.

A case report of the liver hyperplasia developed by taking estrogen drugs.

本邦では極めてまれな,女性ホルモン剤による肝の腫瘍類似病変の1例を報告した.症例は64歳,男性.54歳時に前立腺癌で前立腺および睾丸除去術を受け,内分泌療法として合成女性ホルモン剤のdiethylstilbestrol phosphateを300mg/day,術後10年間にわたって内服していた.食欲不振を主訴に来院し,精査の結果腹部超音波でS8に径2cmのhypo echoic lesionを認め,血管造影でも同部位の濃染像を認めたため,肝細胞癌を強く疑い,S8部分切除術を施行した.切除標本は径15mmの黄色の結節で,組織学的には肝細胞の過形成性病変であり,周囲肝実質を圧排する様に増生していたが,被膜はみられなかった.同部の小葉構築は乱れ,中心静脈の増生を認めたが,核には異型性は認めなかった.FNHなどの既存の疾患の範疇には属さず,肝細胞過形成病変と診断した.