Takekazu Onda

Triple marker screening in native Japanese women

Prenatal screening using the maternal serum markers alpha‐fetoprotein, human chorionic gonadotropin, and unconjugated oestriol was investigated in a native Japanese population. Comparison with a Caucasian U.S. population revealed differences which led to modification of the generally used equations for risk calculations. Prenatal screening was shown to be clinically useful.

Agreement between predicted risk and prevalence of Down syndrome in second‐trimester triple‐marker screening in Japan

Based on 9350 pregnant Japanese women who were screened by serum triple‐marker determination, accuracy of predicted risk for Down syndrome was examined using 24 Down syndrome cases detected either prenatally or postnatally. The correlation is statistically very high (r=0·98) between the predicted risks and the prevalence of Down syndrome cases. Here we emphasize that this could be accomplished only by an extensive follow‐up study, implemented in our prospective intervention programme.

Rapid Detection of Chromosome Aneuploidies by Prenatal Interphase FISH (Fluorescence in situ Hybridization) and Its Clinical Utility in Japan

Objective: The purpose of this study was to assess the accuracy, informative rate, detection rate, and clinical utility of prenatal interphase fluorescence in situ hybridization (FISH) analysis of amniotic fluid samples from Japanese women.

Dimeric Inhibin A as a Fourth Marker for Down's Syndrome Maternal Serum Screening in Native Japanese Women

Objective: This study was conducted to assess the usefulness of dimeric inhibin A as a fourth marker for Downs syndrome screening in addition to AFP, hCG and uE3 markers for native Japanese women.

Triple Marker Screening for Trisomy 21, Trisomy 18 and Open Neural Tube Defects in Singleton Pregnancies of Native Japanese Pregnant Women

Objective: To report the results of prenatal triple marker screening on a population of Japanese pregnant women.