Takeshi Ishigami

Diltiazem-associated photodistributed hyperpigmentation : Report of two Japanese cases and published work review

Scherschum et al. proposed diltiazem‐associated photodistributed hyperpigmentation as a novel type of drug‐induced photosensitive lichenoid eruption. The characteristic clinical features were slate‐gray reticulated hyperpigmentation on sun‐exposed areas, while lichenoid dermatitis with prominent pigmentary incontinence was noted histologically. Although the clinical and histological features were similar to those of lichen planus pigmentosus, the histological features did not show either compact hyperkeratosis or wedge‐shaped hypergranulosis, which are typical histological features of lichen planus. We describe two Japanese cases of diltiazem‐associated photodistributed hyperpigmentation, who were successfully treated with topical tacrolimus, and review the published work.

Germline mutations of the PTCH gene in Japanese patients with nevoid basal cell carcinoma syndrome

Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder characterized by developmental and skeletal anomalies, palmo-plantar pits, odontogenic keratocysts, ectopic calcification, and occurrence of various types of tumors including basal cell carcinoma. Recent evidence has indicated that the human homologue of a Drosophila segment polarity gene, PTCH, is a NBCCS susceptibility gene. In the study presented here, we detected two novel mutations of the PTCH gene, I805X/2395delC and Y93X/C297A, in two unrelated Japanese patients. Early protection of the skin from the sunlight is important to the prevention of BCC development in NBCCS patients. Genetic analysis of the PTCH gene is essential for the early, definitive diagnosis of NBCCS, especially before the expression of clinical manifestations is complete.

Paraneoplastic pemphigus associated with non-Hodgkin's lymphoma

Auteur(s) : Takeshi ISHIGAMI1, Yoshiaki KUBO1 ykubo@clin.med.tokushima-u.ac.jp, Yoshihiro MATSUDATE1, Shinichi ANSAI1, Seiji ARASE1, Bungo OHYAMA2, Takashi HASHIMOTO2 1 Department of Dermatology, University of Tokushima Institute of Health Biosciences, 3-18-15 Kuramoto-cho, 770-8503 Tokushima-city, Japan 2 Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan Paraneoplastic pemphigus (PNP) is an autoimmune blistering disease described first by Anhalt et al. in 1990 [1]. [...]

Bowen disease of the palm associated with human papillomavirus 52.

Human papillomavirus (HPV) is a well‐known risk factor for many human cancers, especially cervical cancers. Among the nonmelanoma skin cancers, Bowen disease (BD) of the genitalia and fingers has also been shown to be closely associated with the high‐risk types of HPV, especially HPV16. We report a case of BD of the palm, which is a very rare location for BD. In addition to its rare location, HPV52, which is classified as a mucous high‐risk HPV type, was detected in the lesion by PCR restriction fragment length polymorphism analysis. To our knowledge, this is the first reported case of BD associated with HPV52.

A case of pyoderma gangrenosum associated with anterior necrotizing scleritis in a patient with ulcerative colitis.

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Drug eruption induced by gonadotropin-releasing hormone analogs accompanying radiation-recall phenomenon

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A Case of Subcutaneous and Mediastinal Emphysema Caused by Dental Treatment

29歳,女性。2002年6月,歯科医院にて左下顎智歯周囲炎を治療中,左頬部の腫脹が出現し,急速に両側頚部に拡大してきたため同日当科紹介受診。初診時,左頬部から両側頚部にかけて腫脹し,触診にて握雪感を認めた。CTで上咽頭から上縦隔に広範囲に皮下気腫がみられ,縦隔内にもガス像を認めたため,歯科治療に使用したエアシリンジによる皮下気腫および縦隔気腫と診断した。予防的にレボフロキサシンを投与し6日目には腫脹は消退した。歯科治療により顔面から頚部の皮下気腫が生じることがあることを知っておく必要があると考える。