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Dive into the research topics where Takeshi Ohnuma is active.

Publication


Featured researches published by Takeshi Ohnuma.


Tetrahedron Letters | 1993

A total synthesis of 6,7-dihydroeponemycin and determination of stereochemistry of the epoxide ring

Hideaki Hoshi; Takeshi Ohnuma; Shimpei Aburaki; Masataka Konishi; Toshikazu Oki

Abstract A total synthesis of 6,7-dihydroeponemycin 2 was achieved via the epoxide intermediate 8a . Unresolved absolute configuration of the epoxide ring in 2 and eponemycin 1 was determined to be 2 R by application of the asymmetric Sharpless epoxidation of 9 .


Archive | 1989

Epipodophyllotoxin altroside derivatives

Takeshi Ohnuma; Hideaki Hoshi; Hideo Kamei; Takayuki Naito


Archive | 1990

Acylated derivatives of etoposide

Takeshi Ohnuma; Rika Obata; Hideo Kamei; Takayuki Naito


The Journal of Antibiotics | 1993

Synthesis and antifungal activity of pradimicin derivatives. Modifications of the sugar part.:MODIFICATIONS OF THE SUGAR PART

Shimpei Aburaki; Haruhiro Yamashita; Takeshi Ohnuma; Hajime Kamachi; Toshio Moriyama; Shinji Masuyoshi; Hideo Kamei; Masataka Konishi; Toshikazu Oki


Archive | 1989

Fluoro-substituted epipodophyllotoxin glucosides

Takeshi Ohnuma; Tetsuro Yamasaki; Hideo Kamei; Takayuki Naito


Archive | 1991

4'-demethylepipodophyllotoxin glycosides

Takeshi Ohnuma; Rika Obata


Archive | 1991

Alkoxymethylidene epipodophyllotoxin glucosides.

Takeshi Ohnuma; Takayuki Naito; Hideo Kamei


Bioscience, Biotechnology, and Biochemistry | 1995

Screening and Production of Arylsulfatases for Target Therapy with Etoposide 4′-Sulfate, an Antitumor Prodrug

Satoshi Yamamoto; Tomokazu Ueki; Koji Tomita; Takeshi Ohnuma; Yosuke Sawada; Yasuo Fukagawa; Toshikazu Oki


Chemical & Pharmaceutical Bulletin | 1992

Preparation and Antitumor Activity of 2"-O-, 3"-O- and 2", 3"-Di-O-substituted Derivatives of Etoposide

Takeshi Ohnuma; Rika Obata; Yuji Nishiyama; Tetsuro Yamasaki; Hideo Kamei; Takayuki Naito; Toshikazu Oki


Chemical & Pharmaceutical Bulletin | 1993

Electrochemical Oxidation of Anti-tumor Agent, Etoposide

Rika Obata; Takeshi Ohnuma

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Satoshi Yamamoto

Takeda Pharmaceutical Company

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