Takeyuki Sanbe

Palatoplasty and Growth of the Temporal Bone Mastoid Air Cells

Objectives The present study was undertaken to analyze the relationship between the method used for manipulation of the levator veli palatini muscle and the area of the mastoid air cells in patients with cleft palate. Design Retrospective study. Patients The subjects were 50 patients seen for surgical treatment of cleft palate. Interventions Palatoplasty was carried out using the mucosal flap method in 25 patients and the mucoperiosteal flap method in 25 patients. In the mucosal flap method, the levator veli palatini muscle was overlapped and sutured, followed by posterior movement of the muscle bundle (the posterior relocation group). In the mucoperiosteal flap method (the control group), the mucoperiosteal flap was pushed back, followed by end-to-end suturing of the muscle. The area of the mastoid air cells was measured on X-rays when patients were 5 years old. Results The mastoid air cell area did not differ significantly between the posterior relocation group (mean, 5.00 cm2; range, 1.66 to 19.7 cm2) and the control group (mean, 5.3 cm2; range, 2.29 to 15.9 cm2). Conclusion No significant growth of mastoid air cells was noted following posterior relocation of the levator veli palatini muscle. Thus, in cases of cleft palate in which significant growth of mastoid air cells is not expected following reconstruction of the levator veli palatini muscle, the results confirm the view that tympanic ventilation tube insertion is the most suitable method for the treatment of otitis media.

Association of aging with glomerular filtration changes in cardiac rehabilitation participants with chronic kidney disease

a Division of Cardiology, Showa University Fujigaoka Rehabilitation Hospital, Yokohama, Japan b Cardiac Rehabilitation, Showa University Fujigaoka Rehabilitation Hospital, Yokohama, Japan c Division of Cardiology, Showa University Fujigaoka Hospital, Yokohama, Japan d Showa University Research Institute for Sport and Exercise Sciences, Yokohama, Japan e Department of Physical Therapy, School of Health Sciences, Tokyo University of Technology, Tokyo, Japan

Basic and clinical immunology – 3025. Suppression of eosinphil activation by levocetirizine hydrochloride in vivo

Methods The influence of histamine H1 receptor antagonists on eosinophil functions was examined through the choice of levocetirizine hydrochloride (LH) in vivo.Patients with Japanese cedar pollinosis were orally treated with LH once a day at a single dose of 5 mg for two weeks during Japanese cedar pollen season (February 2012 to April 2012). Nasal secretions were obtained before and after treatment with the filter paper method. Eosinophil activation was assessed by measuring the levels of both ECP and MBP in nasal secretions by ELISA. We also examined the number of eosinophils in nasal secretions and IgE levels in peripheral blood obtained from patients before and after treatment with LH.

Basic and clinical immunology – 3023. Influence of fexofenadine hydrochloride on uteroglobin production from nasal epithelial cells in vitro and in vivo

Background Uteroglobin (CC10) is well known to be an immuno-suppressive protein secreted from airway epithelial cells after inflammatory stimulation and function in development of allergic disorders. Although histamine H1 receptor antagonists are used for the treatment of allergic disorders, the influence of the agents on CC10 production is not well understood. In the present study, we examined the influence of a histamine H1 receptor antagonist, fexofenadine hydrochloride (FEX) on CC10 production in vitro and in vivo.

Conservative medical treatment of salivary fistulas of post-surgical parotid tumors

対象は，2004年4月から2009年8月までに当科で耳下腺腫瘍の手術を行った178例のうち術後合併症として唾液瘻を併発した8例である。方法は，まず皮下に貯留している唾液を圧迫し手術時の皮膚切開線から排泄させる。唾液の排泄される部位にトレチノイントコフェリル軟膏をすり込むように塗布する。また創部は毎日シャワーにて洗浄し，同軟膏を塗布する。結果として手術から唾液瘻発生までの期間は，6～27日であり，平均12.6日であった。唾液瘻を確認し，本治療法にて治療を開始してから治癒までの期間は，14～31日であり平均17.8日であった。本治療法は，患者のQOLの向上，医療者側の負担を減らすことができると考えられ，今後耳下腺腫瘍手術後の唾液瘻治療の選択肢の一つになると考えられた。