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Takumi Tanaka

Georgia Institute of Technology

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Featured researches published by Takumi Tanaka.

Biochemical and Biophysical Research Communications | 1983

Novel substrates for angiotensin I converting enzyme

Louis B. Hersh; John T. Gafford; James C. Powers; Takumi Tanaka; Ervin G. Erdös

Homogenous human angiotensin converting enzyme (EC 3.4.15.1) cleaves dipeptides from the C-terminus of substrates containing a free carboxyl group. In this study we demonstrate that peptides containing a C-terminal nitrobenzylamine are also cleaved by the enzyme. The hydrolysis of these substrates is inhibited by the specific converting enzyme inhibitors captopril and MK421 as well as by anti-converting enzyme antibody. Sodium chloride accelerates the rate of hydrolysis forty-fold. The product of the reaction, an amino acid nitrobenzylamide, was identified by thin layer chromatography and high performance liquid chromatography. These results suggest that the carboxyl group is not an absolute requirement for substrate hydrolysis.

Biochemistry | 1985

Mammalian chymotrypsin-like enzymes.Comparative reactivities of rat mast cell proteases, human and dog skin chymases, and human cathepsin G with peptide 4-nitroanilide substrates and with peptide chloromethyl ketone and sulfonyl fluoride inhibitors

James C. Powers; Takumi Tanaka; J. Wade Harper; Yoshihiro Minematsu; Larry Barker; Danforth Lincoln; Katherine V. Crumley; Jorma E. Fräki; Norman M. Schechter; Gerald G. Lazarus; Kiichiro Nakajima; Katsuhiro Nakashino; Hans Neurath; Richard G. Woodbury

Bulletin of the Chemical Society of Japan | 1978

Studies on Aziridine-2-carboxylic Acid. I. Synthesis of the Optically Active L-Aziridine-2-carboxylic Acid and Its Derivatives

Kiichiro Nakajima; Fumiko Takai; Takumi Tanaka; Kenji Okawa

Biochemistry | 1985

Human leukocyte cathepsin G. Subsite mapping with 4-nitroanilides, chemical modification, and effect of possible cofactors.

Takumi Tanaka; Yoshihiro Minematsu; Christopher F. Reilly; James Travis; James C. Powers

Biochemistry | 1984

Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates

Kyujin Cho; Takumi Tanaka; Robert R. Cook; Walter Kisiel; Kazuo Fujikawa; Kotoku Kurachi; James C. Powers

Bulletin of the Chemical Society of Japan | 1980

Studies on 2-aziridinecarboxylic acid. III. Reaction of 1-acyl-2-aziridinecarboxylic acid peptide with amines.

Kiichiro Nakajima; Takumi Tanaka; Kaoru Morita; Kenji Okawa

Bulletin of the Chemical Society of Japan | 1980

Studies on 2-aziridinecarboxylic acid. IV. Total synthesis of actinomycin D (C1) via ring-opening reaction of aziridine.

Takumi Tanaka; Kiichiro Nakajima; Kenji Okawa

Bulletin of the Chemical Society of Japan | 1982

Studies on 2-Aziridinecarboxylic Acid. VIII. Total Synthesis of Actinomycin D and Its Serine Analogue via Ring-opening Reaction of 1-Benzyloxycarbonyl-2-aziridinecarboxylic Acid Moiety

Kiichiro Nakajima; Takumi Tanaka; Masahiro Neya; Kenji Okawa

Bulletin of the Chemical Society of Japan | 1979

Studies on 2-aziridinecarboxylic acid. II. A novel synthesis of threonine O-peptide derivatives via (2S,3S)-3-methyl-2-aziridinecarboxylic acid.

Takumi Tanaka; Kiichiro Nakajima; Toru Maeda; Akihiro Nakamura; Noboru Hayashi; Kenji Okawa

Bulletin of the Chemical Society of Japan | 1982

Studies on 2-aziridinecarboxylic acid. V. Formation of dehydroamino acid containing peptides via the isomerization by NaI of 2-aziridinecarboxylic acid containing peptides.

Kenji Okawa; Kiichiro Nakajima; Takumi Tanaka; Masahiro Neya

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Kenji Okawa

Kwansei Gakuin University

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Kiichiro Nakajima

Kwansei Gakuin University

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James C. Powers

Georgia Institute of Technology

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Louis B. Hersh

University of Kentucky

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Yoshihiro Minematsu

Georgia Institute of Technology

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Akihiro Nakamura

Okayama University

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Katsuhiro Nakashino

Kwansei Gakuin University

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Christopher F. Reilly

University of Georgia

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Danforth Lincoln

Georgia Institute of Technology

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Ervin G. Erdös

University of Texas System

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