Takuya Uchida
University of Tokyo
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Publication
Featured researches published by Takuya Uchida.
Bioorganic & Medicinal Chemistry Letters | 2002
Satoru Kaneko; Masami Arai; Takuya Uchida; Tamako Harasaki; Takashi Fukuoka; Toshiyuki Konosu
Sordaricin analogues possessing 6-methoxy-7-methyl-1,4-oxazepane moiety instead of the sugar part were synthesized and evaluated. It was found that N-substituents on the oxazepane ring had influence on biological activity. In particular, N-(2-methylpropenyl) derivative 12p exhibited potent in vitro antifungal activity. Furthermore, 12p maintained significant activity (MIC 0.25 microg/mL) against Candida albicans SANK51486 even in the presence of 20% horse serum.
Bioorganic & Medicinal Chemistry Letters | 2002
Satoru Kaneko; Takuya Uchida; Satoshi Shibuya; Takeshi Honda; Isao Kawamoto; Tamako Harasaki; Takashi Fukuoka; Toshiyuki Konosu
Sordaricin derivatives possessing a cyclohexane ring appendage attached via an ether, thioether, amine, oxime, ester or amide linkage were synthesized and their antifungal activity was evaluated in vitro. Compounds containing a thioether bond or an oxime bond as a linkage exhibited potent MICs (< or = 0.125 microg/mL) against four Candida albicans strains including azole-low-susceptible strains. They were also active (MIC < or = 0.125 microg/mL) against Candida glabrata. Their in vivo efficacy was confirmed in a murine intravenous infection model with Candida albicans.
Tetrahedron Letters | 1997
Yasuyuki Endo; Takuya Uchida; Koichi Shudo
Abstract N-Acyl-N′-phenylhydrazines rearrange under basic conditions to afford o-aminophenyl-acetamides. This reaction can be rationalized in terms of [3,3] sigmatropic shifts of enolized intermediates. The Sommelet-Hauser-type and Stevens-type rearrangements of both aromatic and aliphatic acylhydrazines compete with the [3,3] rearrangement.
Synthesis | 1994
Yasuyuki Endo; Takuya Uchida; Shoji Hizatate; Koichi Shudo
Chemical & Pharmaceutical Bulletin | 2001
Toshiyuki Konosu; Sadao Oida; Yoshie Nakamura; Shinobu Seki; Takuya Uchida; Atsushi Somada; Makoto Mori; Yoshiko Harada; Yasuki Kamai; Tamako Harasaki; Takashi Fukuoka; Satoshi Ohya; Hiroshi Yasuda; Takahiro Shibayama; Shin-ichi Inoue; Akihiko Nakagawa; Yasuo Seta
Chemical & Pharmaceutical Bulletin | 1994
Takuya Uchida; Yasuyuki Endo; Shoji Hizatate; Koichi Shudo
Heterocycles | 2000
Yasuyuki Endo; Takuya Uchida; Kentaro Yamaguchi
Archive | 2003
Makoto Mori; Yoshiko Kagoshima; Takuya Uchida; Toshiyuki Konosu; Takahiro Shibayama
Archive | 2008
Tsuyoshi Soneda; Hiroshi Takeshita; Yoshiko Kagoshima; Yuko Yamamoto; Takafumi Hosokawa; Toshiyuki Konosu; Nobuhisa Masuda; Takuya Uchida; Issei Achiwa; Junichi Kuroyanagi; Tetsunori Fujisawa; Aki Yokomizo; Tetsuji Noguchi
Archive | 2003
Takuya Uchida; Toshiyuki Konosu