Network


Latest external collaboration on country level. Dive into details by clicking on the dots.

Hotspot


Dive into the research topics where Tamara L. Martin is active.

Publication


Featured researches published by Tamara L. Martin.


Journal of Bone and Joint Surgery, American Volume | 2000

Histological changes in the human anterior cruciate ligament after rupture.

Martha M. Murray; Scott D. Martin; Tamara L. Martin; Myron Spector

Background: Four phases in the response to injury of the ruptured human anterior cruciate ligament are observed histologically; these include an inflammatory phase, an epiligamentous repair phase, a proliferative phase, and a remodeling phase. One objective of this study was to describe the histological changes that occur in the ruptured human anterior cruciate ligament during these phases. Myofibroblast-like cells that contain a-smooth muscle actin are present in the midsubstance of the intact human anterior cruciate ligament. A second objective of this study was to determine whether an increased number of myofibroblast-like cells is found in the midsubstance of the ruptured human anterior cruciate ligament because it was thought that those cells might be responsible in part for the retraction of the ruptured anterior cruciate ligament. In the early phase of this study, it was found that the number of myofibroblast-like cells in the midsubstance of the ruptured anterior cruciate ligament was actually decreased, and this hypothesis was abandoned. During the epiligamentous repair phase, synovial tissue was formed that covered the ends of the ruptured anterior cruciate ligament. Most of the synovial lining cells were myofibroblast-like cells that contained a-smooth muscle actin. The primary objective of this study was to determine the location and the characteristics of the a-smooth muscle actin-containing myofibroblast-like cells that appear in the human anterior cruciate ligament following rupture. Methods: Twenty-three ruptured and ten intact human anterior cruciate ligaments were evaluated for cellularity, nuclear morphology, blood vessel density, and percentage of cells containing a contractile actin isoform, a-smooth muscle actin. The histological features of the synovial and epiligamentous tissues were also described. Results: At no time after rupture was there evidence of tissue-bridging between the femoral and tibial remnants of the anterior cruciate ligament. The ruptured ligaments demonstrated a time-dependent histological response, which consisted of inflammatory cell infiltration up to three weeks, gradual epiligamentous repair and resynovialization between three and eight weeks, and neovascularization and an increase in cell number density between eight and twenty weeks. Compared with the intact ligaments, there was a decrease in the percentage of myofibroblast-like cells containing a-smooth muscle actin within the remnant of the ligament. However, many of the epiligamentous and synovial cells encapsulating the remnants contained a-smooth muscle actin. Conclusions: After rupture, the human anterior cruciate ligament undergoes four histological phases, consisting of inflammation, epiligamentous regeneration, proliferation, and remodeling. The response to injury is similar to that reported in other dense connective tissues, with three exceptions: formation of an a-smooth muscle actin-expressing synovial cell layer on the surface of the ruptured ends, the lack of any tissue bridging the rupture site, and the presence of an epiligamentous reparative phase that lasts eight to twelve weeks. Other characteristics reported in healing dense connective tissue, such as fibroblast proliferation, expression of a-smooth muscle actin, and revascularization, also occur in the ruptured human anterior cruciate ligament. Clinical Relevance: Unlike extra-articular ligaments that heal after injury, the human intra-articular anterior cruciate ligament forms a layer of synovial tissue over the ruptured surface, which may impede repair of the ligament. Moreover, a large number of cells in this synovial layer and in the epiligamentous tissue express the gene for a contractile actin isoform, a-smooth muscle actin, thus differentiating into myofibroblasts. These events may play a role in the retraction and lack of healing of the ruptured anterior cruciate ligament.


Journal of Bone and Joint Surgery, American Volume | 1997

Suprascapular Neuropathy. Results of Non-Operative Treatment*

Scott D. Martin; Russell F. Warren; Tamara L. Martin; Kevin Kennedy; Stephen J. O'Brien; Thomas L. Wickiewicz

We retrospectively reviewed the results of non-operative treatment of suprascapular neuropathy in fifteen patients seen between November 1983 and February 1991. The clinical diagnosis was confirmed with electrodiagnostic studies. The treatment consisted of a program of physical therapy to improve the range of motion of the shoulder and to strengthen the surrounding muscles. The average duration of follow-up was three years and eleven months (range, one year to eight years and ten months). The latest evaluation included electrodiagnostic studies of the affected extremity and dynamic isokinetic testing of both upper extremities. The result was excellent for five patients and good for seven. The three remaining patients had operative treatment because of persistent symptoms; one of these patients had an excellent result, one had a good result, and one had a poor result. The results suggest that, in the absence of a well defined lesion producing mechanical compression of the suprascapular nerve, suprascapular neuropathy should be treated non-operatively.


Orthopedic Clinics of North America | 2002

Anterior cruciate ligament graft fixation

Scott D. Martin; Tamara L. Martin; Charles H. Brown

ACL reconstruction, when performed correctly, has become a reliable, reproducible surgical technique with a predictable outcome. Successful results can be achieved via anatomic reconstruction with rigid fixation of a strong graft. Fixation techniques continue to evolve, with biologic fixation of graft constructs gaining popularity over the past several years. The choice of fixation should be one that provides a firm construct where accelerated rehabilitation can be achieved on all isolated primary ACL reconstructions. The results should be reproducible and, most important, the surgeon should be comfortable and confident with the fixation device. Prior to selecting a particular fixation device, the surgeon should not only be aware of any potential problems noted on biomechanical testing but also have familiarity with the proper use of the device and any clinical follow-up studies in the literature.


Journal of Pediatric Orthopaedics | 1994

Proximal tibial osteotomy with compression plate fixation for tibia vara

Scott D. Martin; Michael C. Moran; Tamara L. Martin; Stephen W. Burke

A surgical technique for the accurate intraoperative correction of tibia vara deformities with maintainence of postoperative alignment is presented. This was a retrospective study of 13 knees of nine patients with tibia vara deformities treated by proximal tibial and fibular osteotomies using compression-plate fixation. Average age of the patients was 9 + 1 years, with a range of 3 + 1 to 14 + 11 years. The average preoperative deformity was 20° of varus with a range of 15–36°. Average follow-up was 3 + 3 years, with a range of 2 to 4 + 1 years. All patients had intraoperative correction to an average valgus of 5° (range 4–8° valgus), with an overall valgus correction of 25° (range 20–40°). There was one reoperation for unilateral recurrence of deformity in a child who progressed from stage III to stage VI postoperatively. Proximal tibial osteotomy with compression-plate fixation provides an accurate and reliable method for the correction of multiplanar deformities in children and adolescents.


Acta Biomaterialia | 2013

Lubricin and smooth muscle α-actin-containing myofibroblasts in the pseudomembranes around loose hip and knee prostheses

Thomas Cheriyan; John E. Ready; Gregory W. Brick; Scott D. Martin; Tamara L. Martin; Thomas M. Schmid; Robert F. Padera; Myron Spector

The objective was to evaluate the presence and distribution of the lubricating and anti-adhesion glycoprotein lubricin and cells containing the contractile isoform smooth muscle α-actin (SMA) in pseudomembranes around loose hip prostheses. Periprosthetic tissue was obtained at revision arthroplasty of eight aseptic, loose hip implants, and for comparison three loose knee prostheses. Immunohistochemical analysis was performed in 3 zones: zone 1, within 300μm of the edge of the implant-tissue interface; zone 2, between zones 1 and 3; zone 3, within 300μm of the resected/trimmed edge. The presence of lubricin was extensive in all samples: (1) as a discrete layer at the implant-tissue interface; (2) within the extracellular matrix (ECM); (3) intracellularly. There was significantly more high grade (>50%) lubricin surface staining at the implant-tissue interface compared with the resected edge. While there was also a significant effect of location of high grade ECM lubricin staining, there was no significant effect of implant type (i.e. hip versus knee). All but two hip pseudomembrane samples showed the presence of many SMA-containing cells. There was a significant effect of location on the number of SMA-expressing cells, but not of implant type. These findings might explain why the management of loose prosthesis is so challenging.


Journal of Bone and Joint Surgery, American Volume | 1996

ARTHROSCOPIC SURGERY. THE FOOT & ANKLE. Richard D. Ferkel. Edited by Terry L. Whipple and illustrated by Susan E. Brust. Philadelphia, Lippincott-Raven, 1996.

Tamara L. Martin; Michael G. Wilson

This comprehensive text will be of interest to orthopaedic surgeons specializing in the treatment of the foot and ankle as well as to practitioners specializing in sports medicine. Rather than being just a manual on technique, this impressive work covers all aspects of arthroscopy of the foot and ankle—including historical perspectives, instrumentation, operating-room setup, specific operative indications, and potential complications—in encyclopedic …


Contemporary Clinical Trials | 2005

139.00, 335 pp.

Alisha H. Creel; Elena Losina; Lisa A. Mandl; Robert J. Marx; Nizar N. Mahomed; Scott D. Martin; Tamara L. Martin; Peter J. Millett; Anne H. Fossel; Jeffrey N. Katz


JAMA Internal Medicine | 2004

An assessment of willingness to participate in a randomized trial of arthroscopic knee surgery in patients with osteoarthritis.

Daniel H. Solomon; Jerry Avorn; Asra Warsi; Charles H. Brown; Scott D. Martin; Tamara L. Martin; John Wright; Michele Burgener; Jeffrey N. Katz


Archive | 2008

Which Patients With Knee Problems Are Likely to Benefit From Nonarthroplasty Surgery?: Development of a Clinical Prediction Rule

Tamara L. Martin; Scott D. Martin; Magruder C. Donaldson


Trib. méd. (Bogotá) | 1998

Mechanical Leg Pain

Scott D. Martin; Tamara L. Martin

Collaboration


Dive into the Tamara L. Martin's collaboration.

Top Co-Authors

Avatar
Top Co-Authors

Avatar

Charles H. Brown

Brigham and Women's Hospital

View shared research outputs
Top Co-Authors

Avatar

Jeffrey N. Katz

Brigham and Women's Hospital

View shared research outputs
Top Co-Authors

Avatar

Michael G. Wilson

Brigham and Women's Hospital

View shared research outputs
Top Co-Authors

Avatar

Myron Spector

Brigham and Women's Hospital

View shared research outputs
Top Co-Authors

Avatar

Alisha H. Creel

Brigham and Women's Hospital

View shared research outputs
Top Co-Authors

Avatar

Anne H. Fossel

Brigham and Women's Hospital

View shared research outputs
Top Co-Authors

Avatar

Asra Warsi

Brigham and Women's Hospital

View shared research outputs
Top Co-Authors

Avatar

Daniel H. Solomon

Brigham and Women's Hospital

View shared research outputs
Top Co-Authors

Avatar

Elena Losina

Brigham and Women's Hospital

View shared research outputs
Researchain Logo
Decentralizing Knowledge