Tanzer Korkmaz

Effect of Ankaferd Blood Stopper on air leakage in the lung and prevention of bleeding: an experimental study

BackgroundAir leakage and hemorrhage are important causes of morbidity and mortality in operations and traumas of the lung. Ankaferd Blood Stopper is a herbal product used for stopping hemorrhage. In our study, we investigated the efficacy of Ankaferd Blood Stopper in the prevention of air leakage in the lung and bleeding.MethodsA total of twenty-one Wistar-Albino rats weighing 240 ± 20 grams were used in our study. An equal amount of injury was created in all groups by performing left thoracotomies. No interventions were made on tissue injury in the first group, and suturing was performed in the second group, and Ankaferd was applied in the third group. Air leakage and duration of bleeding were recorded in all groups.ResultsA statistically significant difference was found between the three groups in terms of air leakage time (p = 0,0001) and bleeding time (p = 0,0001). While a significant effect of Ankaferd was detected in terms of air leakage compared to standard surgery (p = 0,017), no difference was found in terms of bleeding time.ConclusionsAnkaferd Blood Stopper ceases the air leakage in the lung parenchyma significantly and effectively. No significant difference is seen compared to the standard surgery group, although it ceases bleeding significantly.

The effect of erythropoietin to pulmonary injury and mast cells secondary to acute pancreatitis

BackgroundAcute pancreatitis is a life-threatening necroinflammatory disease that is characterized by systemic inflammatory response syndrome and acute lung injury even in its very first days. Erythropoietin (EPO) is a hormone considered as an antiapoptotic and cytoprotective with observed receptors of anti-inflammatory effect on organs apart from the liver and the kidneys. In this study, the effects of EPO on pulmonary mast cells and on secondary injury caused by acute pancreatitis are investigated.MethodsTwenty one Wistar Albino rats were divided into three groups—sham, control, and EPO groups—with 7 rats per group. Pancreatitis was induced by administering 4.5% sodium taurocholate into the pancreatic duct. A 1000 U/kg/day dosage (three times) of EPO was administered to the EPO group. Blood urea nitrogen (BUN), creatinine, amylase, and troponin I in the serum were studied; and lung, kidney, brain, and heart tissues were examined histopathologically.ResultsThere were no histopathological changes in the other organ tissues except for the lung tissue. Compared to the control group, the EPO group showed significantly reduced alveolar hemorrhage, septal neutrophil infiltration, lung wall thickness score, and mast cell count in the lung tissue.ConclusionsAdministration of EPO reduces the mast cell count and lung wall thickness, and it reduces the alveolar hemorrhage and septal infiltration induced by acute pancreatitis.

The Effects of Oral Antibiotics on Infection Prophylaxis in Traumatic Wounds

BACKGROUND The objective of this study is to examine the effectiveness of oral antibiotics in the prevention of infection development in traumatic wounds. METHODS Forty Wistar albino rats were divided into five groups of eight animals. After the crushed wound model was made on the back of the rats, wounds were closed with a simple suture and Staphylococcus aureus ATCC 29213 strain was used to create infection. All rats apart from the controls were given oral gavage with antibiotics, including cephalexin, amoxicillin-clavulanate, clarithromycin (CAM), or levofloxacin for 5 days. Wounds were evaluated qualitatively and quantitatively on 5th day approximately 18 h after the last treatment. RESULTS In the quantitative evaluation, no infection was observed in the treatment groups with amoxicillin-clavulanate, CAM, cephalexin, or levofloxacin. There was no significant difference on the numbers of bacteria found in the wounds among the groups. In terms of quantitative inflammation findings, no hyperemia or pus was detected in the groups that were given medication. Furthermore, no statistically significant difference was found among the groups in terms of induration. CONCLUSION Oral prophylactic antibiotics have been found to be effective in the prevention of wound infection in the traumatic crushed wound model infected with S. aureus in rats.

The Effects of Ankaferd Blood Stopper on the Recovery Process in an Experimental Oesophageal Perforation Model

BACKGROUND Oesophageal perforation is a life-threatening pathology that is generally treated conservatively; however, surgical procedures are frequently performed. A topical haemostatic agent, Ankaferd Blood Stopper (ABS), also has beneficial wound-healing effects. AIMS This study aimed to determine the effects of ABS following experimental oesophageal perforations. STUDY DESIGN Animal experiment. METHODS The experimental rats were classified into 6 groups (with 7 rats in each group). Pairs of groups (primary repair alone and primary repair + ABS) were terminated in the 1(st), 2(nd), and 3(rd) weeks following injury. The oesophageal perforations, which were 8-10 mm in length, were created using a nasogastric tube. The perforation sites were repaired with a 6-0 polyglactine thread in the primary repair groups. Additionally, ABS was sprayed over the perforation site in the treatment groups. Each oesophagus was evaluated histopathologically. RESULTS There were fewer microabscesses and areas of necrosis in the ABS groups compared with the primary repair groups. The histopathological evaluation revealed that the ABS groups had less inflammation and more re-epithelisation compared to the primary repair groups (p=0.002 and p=0.003, respectively). Fibrosis in the ABS groups was moderate in the 2(nd) week and mild in the 3(rd) week. Comparing the groups with respect to the time intervals, only the 1(st) week groups showed a significant difference in terms of re-epithelialisation (p=0.044). CONCLUSION Topical ABS application on the repaired experimental oesophageal perforation regions led to positive wound-healing effects compared with the rats that were administered the primary repair alone.

Tek doz duloksetin genç erkek hastada hiponatremiye neden olabilir mi

Somatik semptomlari olan orta yasli bir erkek hastada tek doz duloksetin tedavi sonrasi hizlica gelisen bir hiponatremi olgusunu rapor ettik. Yirmi sekiz yasinda erkek hasta halsizlik ve basdonmesi sikayeti ile basvurdu. Duloksetinin kesilmesi ve normal salin tedavisinden uc gun sonra tamamen normale dondu. Duloksetin ile tedavi edilen hastalarin hiponatremi acisindan yakin takiplerinin yapilmasi gereklidir.

İlginç Bir İnhaler Cihaz Kazasi; Çivi Aspirasyonu Olgusu

Sonucta bu olgu bildirimi, KOAH tanisiyla bron- kodilatator ilac kullanimi sirasinda inhaler cihaz icinde biraktigi civiyi aspire etmis olan yasli bir hastada oldugu gibi, ender olarak olusabilecek as- pirasyonlari onleyebilme adina, riskli hasta grup- larinda tibbi cihaz ve ilaclarin kullanimi hakkin- da daha iyi bilgilendirmenin onemini vurgulamak amaciyla sunulmustur

Ölüm Raporlarında Belirtilen Ölüm Nedenlerinin Kendi Aralarında ve ICD Kodlarıyla Uyumunun Değerlendirilmesi

Bulgular: İki yıllık sürede toplam 351 olgunun 218’inin (%62,1) erkek ve yaş ortalamalarının da 67,1±0,7 olduğu tespit edildi. Hastane içi ölümlerin %87,5’inin (n=307) 60 yaş ve üzerinde ve yoğun bakımda gerçekleştiği, ölüme kadar geçen süre ortalamasının 15,4±25,4 saat olduğu görüldü. Doğrudan ölüme sebep olan hastalık veya durumların %23,9’unun (n=84) kalp-pompa yetmezliği hastalıkları ve %19,9’unun (n=70) da “kardiyopulmoner arrest” olarak kaydedildiği ve ilk kaydedilen ICD kodunda en fazla uyumluluğun MI olgularında olduğu görüldü.

Analgesic treatment in patients with acute extremity trauma and effect of training

SUMMARY Objectives Studies indicate that emergency physicians (EP) under-evaluate and undertreat the pain experienced by their patients. The objective of this study was to investigate how EPs treat pain in adult patients with limb trauma and to determine if their behavior could be affected by training in the short-term.