Taro Kazuno

Chemistry and Metabolism of Bile Alcohols and Higher Bile Acids

Publisher Summary This chapter discusses the chemistry and metabolism of bile alcohols and higher bile acids. The bile acids, occurring in the bile of mammals, birds, some snakes, and most bony fish are all mono-, di-or trihydroxy derivatives of the cholanoic acid. These C 24 acids have been shown to be made biosynthetically from a C 27 sterol, cholesterol—a process involving loss of the terminal three carbon atoms in the side chain. Early studies on the metabolism of bile alcohols and higher bile acids were concerned mainly with the role of these compounds as the intermediates in the formation of C 24 bile acids from cholesterol in mammals. There is no doubt that these experiments made valuable contributions to the studies of mammalian bile acid biosynthesis. The next biochemical problem will be to elucidate the formation of the bile alcohols and the higher bile acids themselves. Comparative studies on the biosynthetic pathways of these compounds in primitive animals will provide additional information on the formation of the common bile acids and will serve as a better guide regarding the evolution of bile salts. Investigations in this field have been undertaken only quite recently.

Stero-bile acids and bile sterols. LVII. Chromatography of bile alcohols

Abstract This paper describes the column, paper and thin layer Chromatographic characteristics of 40 different bile alcohols that were synthesized or isolated from bile in this laboratory. Bile alcohols differing not only in number, character and position of polar groups but also in A/B ring junction and in length of the side chain are separable by methods to be described.

Synthese Der Stero‐Gallensäuren XXVIII. Partialsynthese Der 24‐äthyl‐Koprostansäure

Ausgehend von Cholansaure lies sich eine 24-Athyl-koprostansaure, die als Derivat des Stigmasterins erscheint, in 5 Reaktions-Stufen gewinnen.