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Tatiana Pilyugina

Broad Institute

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Publication

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Archive | 2014

Identification of ML359 as a Small Molecule Inhibitor of Protein Disulfide Isomerase

Carol Khodier; Lynn VerPlank; Partha Nag; Jun Pu; Jacqueline Wurst; Tatiana Pilyugina; Chris Dockendorff; Christine N. Galinski; Alissa A. Scalise; Freda Passam; Lotte van Hessem; James Dilks; Daniel R. Kennedy; Robert Flaumenhaft; Michelle Palmer; Sivaraman Dandapani; Benito Munoz; Stuart L. Schrieber

Blood | 2013

Development Of Second Generation Thiol Isomerase Inhibitors To Prevent Thrombus Formation

Partha Nag; Christine N. Galinski; Sheryl R. Bowley; Roelof H. Bekendam; James Dilks; Alissa A. Scalise; Lotte van Hessem; Jun Pu; Tatiana Pilyugina; Sivaraman Dandapani; Benito Munoz; Robert Flaumenhaft

Archive | 2014

Table 4, SAR Analysis: Modification of ester functionality

Carol Khodier; Lynn VerPlank; Partha Nag; Jun Pu; Jacqueline Wurst; Tatiana Pilyugina; Chris Dockendorff; Christine N. Galinski; Alissa A. Scalise; Freda Passam; Lotte van Hessem; James Dilks; Daniel R. Kennedy; Robert Flaumenhaft; Michelle Palmer; Sivaraman Dandapani; Benito Munoz; Stuart L. Schrieber

Archive | 2014

Figure 4, Dose-dependent Activity of the Probe (ML359) in the inhibition of PDI-induced insulin aggregation

Carol Khodier; Lynn VerPlank; Partha Nag; Jun Pu; Jacqueline Wurst; Tatiana Pilyugina; Chris Dockendorff; Christine N. Galinski; Alissa A. Scalise; Freda Passam; Lotte van Hessem; James Dilks; Daniel R. Kennedy; Robert Flaumenhaft; Michelle Palmer; Sivaraman Dandapani; Benito Munoz; Stuart L. Schrieber

Archive | 2014

Table 10, Platelet Aggregation Activity and Platelet Aggregation Reversibility: Profile of ML359, CID 70701242 and CID 70701237

Carol Khodier; Lynn VerPlank; Partha Nag; Jun Pu; Jacqueline Wurst; Tatiana Pilyugina; Chris Dockendorff; Christine N. Galinski; Alissa A. Scalise; Freda Passam; Lotte van Hessem; James Dilks; Daniel R. Kennedy; Robert Flaumenhaft; Michelle Palmer; Sivaraman Dandapani; Benito Munoz; Stuart L. Schrieber

Archive | 2014

Table 9, Prior Art Database Search

Carol Khodier; Lynn VerPlank; Partha Nag; Jun Pu; Jacqueline Wurst; Tatiana Pilyugina; Chris Dockendorff; Christine N. Galinski; Alissa A. Scalise; Freda Passam; Lotte van Hessem; James Dilks; Daniel R. Kennedy; Robert Flaumenhaft; Michelle Palmer; Sivaraman Dandapani; Benito Munoz; Stuart L. Schrieber

Archive | 2014

Table 8, Comparison of the Probe ML359 to Project Criteria

Carol Khodier; Lynn VerPlank; Partha Nag; Jun Pu; Jacqueline Wurst; Tatiana Pilyugina; Chris Dockendorff; Christine N. Galinski; Alissa A. Scalise; Freda Passam; Lotte van Hessem; James Dilks; Daniel R. Kennedy; Robert Flaumenhaft; Michelle Palmer; Sivaraman Dandapani; Benito Munoz; Stuart L. Schrieber

Archive | 2014

Figure 2, Stability of the probe (ML359, CID 23723882) in presence of glutathione

Carol Khodier; Lynn VerPlank; Partha Nag; Jun Pu; Jacqueline Wurst; Tatiana Pilyugina; Chris Dockendorff; Christine N. Galinski; Alissa A. Scalise; Freda Passam; Lotte van Hessem; James Dilks; Daniel R. Kennedy; Robert Flaumenhaft; Michelle Palmer; Sivaraman Dandapani; Benito Munoz; Stuart L. Schrieber

Archive | 2014

Figure 1, Stability of the Probe (ML359, CID 23723882) in PBS Buffer (pH 7.4, 23°C)

Carol Khodier; Lynn VerPlank; Partha Nag; Jun Pu; Jacqueline Wurst; Tatiana Pilyugina; Chris Dockendorff; Christine N. Galinski; Alissa A. Scalise; Freda Passam; Lotte van Hessem; James Dilks; Daniel R. Kennedy; Robert Flaumenhaft; Michelle Palmer; Sivaraman Dandapani; Benito Munoz; Stuart L. Schrieber

Archive | 2014

Table 5, Selectivity profile of ML359 and selective analogues

Carol Khodier; Lynn VerPlank; Partha Nag; Jun Pu; Jacqueline Wurst; Tatiana Pilyugina; Chris Dockendorff; Christine N. Galinski; Alissa A. Scalise; Freda Passam; Lotte van Hessem; James Dilks; Daniel R. Kennedy; Robert Flaumenhaft; Michelle Palmer; Sivaraman Dandapani; Benito Munoz; Stuart L. Schrieber

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Collaboration

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Alissa A. Scalise

Western New England University

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Benito Munoz

Broad Institute

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Christine N. Galinski

Western New England University

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James Dilks

Beth Israel Deaconess Medical Center

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Jun Pu

Broad Institute

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Lotte van Hessem

Beth Israel Deaconess Medical Center

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Partha Nag

Broad Institute

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Sivaraman Dandapani

Broad Institute

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Carol Khodier

Broad Institute

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Chris Dockendorff

Broad Institute

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