Tatiane Caroline Daboit
Universidade Federal do Rio Grande do Sul
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Featured researches published by Tatiane Caroline Daboit.
Mycoses | 2014
Tatiane Caroline Daboit; Cibele Massotti Magagnin; Daiane Heidrich; Laura Czekster Antochevis; Suelen Vigolo; Lúcia Collares Meirelles; Karine de Oliveira Alves; Maria Lúcia Scroferneker
Chromoblastomycosis is a chronic mycosis that affects the skin and subcutaneous tissues caused by several genera of dematiaceous fungi. There is not a treatment of choice. Thus, tools that help guide clinical practice are fundamental. In this sense, antifungal activity tests in vitro could be useful. However, trials with chromoblastomycosis agents are scarce. The aim of this study was to evaluate both the in vitro susceptibility of 60 chromoblastomycosis agents to five antifungals and the combination of amphotericin B (AMB) and terbinafine (TRB). TRB, itraconazole (ITZ) and ketoconazole (KTZ) were, in this order, the drugs which showed better activity against the chromoblastomycosis agents. The less active drugs were voriconazole (VRZ) and AMB. The more differentiated group was Exophiala spinifera. Cladophialophora carrionii and Fonsecaea spp. are significantly more susceptible to KTZ than Phialophora verrucosa, whereas C. carrionii is significantly more sensitive to VRZ than P. verrucosa and E. spinifera. Assays in this direction allow the knowledge of the susceptibility of the causative agents which may help the management of patients with this disease. This study includes the largest number of these agents and of genera found in the literature.
Medical mycology case reports | 2012
Tatiane Caroline Daboit; Rodrigo Pereira Duquia; Cibele Massotti Magagnin; Sandra Denise Camargo Mendes; Mauricio Ramírez Castrillón; Raquel Steglich; Inajara Silveira dos Santos; Gerson Vettorato; Patricia Valente; Maria Lúcia Scroferneker
We report a case of an 80-year-old Brazilian man, farmer, with lesions on the dorsum of the hand. A direct mycological examination, cultivation and microculture slide observation was performed. The sequencing of ITS1-5.8S rDNA-ITS2 region was carried out and the etiological agent confirmed as Exophiala spinifera. The in vitro susceptibility of this isolate to antifungal agents alone and in combination was evaluated. This is the third case of phaeohyphomycosis caused by Exophiala spinifera in Brazil.
Mycoses | 2010
Tatiane Caroline Daboit; Cheila Denise Ottonelli Stopiglia; Gilsane Lino von Poser; Maria Lúcia Scroferneker
Plants of the genus Pterocaulon (Asteraceae) are popularly used in the treatment of skin diseases caused by fungi and bacteria. The aim of this work was to investigate the in vitro activity of the crude methanolic extract obtained from the aerial parts of Pterocaulon alopecuroides (Lam.) against some agents of chromoblastomycosis, a chronic fungal infection of the skin and of the subcutaneous tissue caused by traumatic inoculation of the aetiological agent. The extract was active against all the strains tested showing a minimum inhibitory concentration between 625 and 2500 μg ml−1. The assessment of fungistatic/fungicidal activity demonstrated that the extract was fungistatic against Fonsecaea spp. and fungicidal against all the other fungi. Our results indicate that the identification of bioactive components present in the crude methanolic extract of P. alopecuroides against chromoblastomycosis agents can be an important strategy to manage this mycosis in the future.
Journal of Infection in Developing Countries | 2015
Daiane Heidrich; Marcelo Rocha Garcia; Cheila Denise Ottonelli Stopiglia; Cibele Massotti Magagnin; Tatiane Caroline Daboit; Gerson Vetoratto; Joel Schwartz; Taís Guarienti Amaro; Maria Lúcia Scroferneker
INTRODUCTION Dermatophytoses are considered a public health problem. The objectives of this study were to determine the evolution of their prevalence in the metropolitan area of Porto Alegre, Brazil, and to analyze the dermatophyte species distribution according to body site and demographic characteristics of the patients. METHODOLOGY This work was a retrospective analysis of data from patients attending a tertiary care hospital during 1996-2011. RESULTS There were 9,048 cases with cultures positive for dermatophytes. Trichophyton rubrum occurred in 59.6% of the cases, followed by Trichophyton interdigitale (34%), Microsporum canis (2.6%), Epidermophyton floccosum (1.5%), Microsporum gypseum (1.3%), and Trichophyton tonsurans (0.9%). The angular coefficients for T. interdigitale, E. floccosum, T. rubrum, and M. canis were +1.119, +0.211, -0.826 and -0.324% per year, respectively. Males presented higher prevalence of infection (79.3% versus 53.9%). Tinea unguium occurred in 48.5% of the cases, followed by tinea pedis (33.1%). T. rubrum was the predominant species in all regions of the body except the scalp, where M. canis was responsible for 75% of the cases. CONCLUSION Monitoring of the evolution of dermatophytosis tracks changes in prevalence over the years and may assist practical measures for the public health control of this disease.
Mycoses | 2009
Tatiane Caroline Daboit; Cheila Denise Ottonelli Stopiglia; Mariana Carissimi; Valeriano Antonio Corbellini; Valter Stefani; Maria Lúcia Scroferneker
The development of azole antifungals has allowed for the treatment of several fungal infections. However, the use of these compounds is restricted because of their hepatotoxicity or because they need to be administered together with other drugs in order to prevent resistance to monotherapy. Benzoxazole derivatives are among the most thriving molecular prototypes for the development of antifungal agents. 2‐(2′‐hydroxyphenyl) benzoxazoles are versatile molecules that emit fluorescence and have antibacterial, antiviral and antifungal properties. 2‐(2′‐hydroxy‐5′‐aminophenyl) benzoxazole (HAMBO) was tested against Candida yeast. The inhibition provided by HAMBO was lower than that of fluconazole, showing low antifungal activity against Candida spp., but equivalent to that of benzoxazoles tested in similar studies. HAMBO showed fungistatic activity against all analysed strains. This class of novel benzoxazole compounds may be used as template to produce better antifungal drugs.
Revista Do Instituto De Medicina Tropical De Sao Paulo | 2013
Cheila Denise Ottonelli Stopiglia; Mariana Carissimi; Tatiane Caroline Daboit; Valter Stefani; Valeriano Antonio Corbellini; Maria Lúcia Scroferneker
Introduction Sporothrix schenckii is a thermal dimorphic pathogenic fungus causing a subcutaneous mycosis, sporotrichosis. Nitrocoumarin represents a fluorogenic substrate class where the microbial nitroreductase activity produces several derivatives, already used in several other enzyme assays. The objective of this study was the analysis of 6-nitrocoumarin (6-NC) as a substrate to study the nitroreductase activity in Sporothrix schenckii. Methods Thirty-five samples of S. schenckii were cultivated for seven, 14 and 21 days at 35 °C in a microculture containing 6-nitrocoumarin or 6-aminocoumarin (6-AC) dissolved in dimethyl sulfoxide or dimethyl sulfoxide as a negative control, for posterior examination under an epifluorescence microscope. The organic layer of the seven, 14 and 21-day cultures was analyzed by means of direct illumination with 365 nm UV light and by means of elution on G silica gel plate with hexane:ethyl acetate 1:4 unveiled with UV light. Results All of the strains showed the presence of 6-AC (yellow fluorescence) and 6-hydroxylaminocoumarin (blue fluorescence) in thin layer chromatography, which explains the green fluorescence observed in the fungus structure. Conclusion The nitroreductase activity is widely distributed in the S. schenckii complex and 6-NC is a fluorogenic substrate of easy access and applicability for the nitroreductase activity detection.
Revista Do Instituto De Medicina Tropical De Sao Paulo | 2016
Daiane Heidrich; Cheila Denise Ottonelli Stopiglia; Cibele Massotti Magagnin; Tatiane Caroline Daboit; Gerson Vettorato; Tais Guarienti Amaro; Maria Lúcia Scroferneker
The yeasts of the genus Candida infect skin, nails, and mucous membranes of the gastrointestinal and the genitourinary tract. The aim of this study was to determine the prevalence of dermatomycoses caused by Candida spp., and their etiological aspects in the metropolitan area of Porto Alegre, Brazil. A retrospective study with data obtained from tertiary hospital patients, from 1996 to 2011, was performed. The analyzed parameters were date, age, gender, ethnicity, anatomical region of lesions, and the direct examination results. For all the statistical analyses, a = 0.05 was considered. Among positive results in the direct mycological examination, 12.5% of the total of 4,815 cases were positive for Candida spp. The angular coefficient (B) was -0.7%/ year, showing a decrease over the years. The genus Candida was more prevalent in women (15.9% of women versus 5.84% of men), and in addition, women were older than men (54 versus 47 years old, respectively). There was no difference between ethnic groups. The nails were more affected than the skin, with 80.37% of the infections in the nails (72.9% in fingernails and 7.47% in toenails). Our study corroborates the literature regarding the preference for gender, age, and place of injury. Moreover, we found a decrease in infection over the studied period.
Revista Brasileira de Biociências | 2014
Paula Mattana; Priscila Raupp da Rosa; Jandora Severo Poli; Neila Silvia Pereira dos Santos Richards; Tatiane Caroline Daboit; Maria Lúcia Scroferneker; Ana Paula Winter Pastore; Gertrudes Corção; Francisco Carlos Deschamps; Fabiano Cleber Bertoldi; Patricia Valente
Mycopathologia | 2013
Tatiane Caroline Daboit; Cibele Massotti Magagnin; Daiane Heidrich; Mauricio Ramírez Castrillón; Sandra Denise Camargo Mendes; Gerson Vettorato; Patricia Valente; Maria Lúcia Scroferneker
Revista Do Instituto De Medicina Tropical De Sao Paulo | 2015
Daiane Heidrich; Tatiane Caroline Daboit; Cheila Denise Ottonelli Stopiglia; Cibele Massotti Magagnin; Gerson Vetoratto; Taís Guarienti Amaro; Maria Lúcia Scroferneker
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Cheila Denise Ottonelli Stopiglia
Universidade Federal do Rio Grande do Sul
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