Tatsuji Kurose
SANTEN PHARMACEUTICAL CO., LTD.
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Publication
Featured researches published by Tatsuji Kurose.
Journal of Ocular Pharmacology and Therapeutics | 2003
Masatomo Kato; Tatsuji Kurose; Tomoko Oda; Suguru Miyaji
Platelet-activating factor (PAF) may be an important mediator in allergic conjunctivitis. In this study, apafant, a potent PAF antagonist, was evaluated for topical ocular anti-PAF activity in PAF and antigen stimulated conjunctivitis models. PAF, when injected into parpebral conjunctiva, provoked an acute increase, measured as dye leakage, in conjunctival vascular permeability. Apafant inhibited this response in a dose-related manner, and the inhibitory action of 0.1% apafant lasted for at least 6 hours duration. PAF, when instilled into the conjunctival sac, induced itch-scratching behavior and clinical symptoms, such as conjunctival redness and edema. These were inhibited by pretreatment with apafant ophthalmic solution. In a passive conjunctival anaphylaxis model in guinea pigs, significant inhibition of the allergic response was observed following topical ocular administration of apafant 5 and 15 minutes prior to the antigen challenge. We have demonstrated that PAF plays an important role in the development of allergic conjunctivitis. These results clearly indicate that apafant has potential as a topical ocular anti-PAF for treating allergic conjunctivitis.
Archive | 2008
Masatomo Kato; Miwa Takai; Takahiro Matsuyama; Tatsuji Kurose; Yumi Hagiwara; Mamoru Matsuda; Toshiyuki Mori
Archive | 2008
Mamoru Matsuda; Toshiyuki Mori; Masato Nagatsuka; Sachiko Kobayashi; Shinji Takaoka; Masatomo Kato; Miwa Takai; Takahiro Matsuyama; Tatsuji Kurose; Yumi Hagiwara
Archive | 2008
Masatomo Kato; Miwa Takai; Takahiro Matsuyama; Tatsuji Kurose; Yumi Hagiwara; Mamoru Matsuda; Toshiyuki Mori
Archive | 2009
Masatomo Kato; Miwa Takai; Takahiro Matsuyama; Tatsuji Kurose; Yumi Hagiwara; Mamoru Matsuda; Toshiyuki Mori; Kenji Imoto; Atsuyoshi Dota
Archive | 2006
Kouji Oohashi; Reina Doi; Tatsuji Kurose; Masaaki Kageyama
Archive | 2009
Masatomo Kato; Miwa Takai; Takahiro Matsuyama; Tatsuji Kurose; Yumi Hagiwara; Kenji Oki; Mamoru Matsuda; Toshiyuki Mori
Archive | 2011
Kouji Oohashi; Reina Doi; Tatsuji Kurose; Masaaki Kageyama
Archive | 2011
Kouji Oohashi; Reina Doi; Tatsuji Kurose; Masaaki Kageyama
Archive | 2009
Masatomo Kato; Miwa Takai; Takahiro Matsuyama; Tatsuji Kurose; Yumi Hagiwara; Kenji Oki; Mamoru Matsuda; Toshiyuki Mori