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Featured researches published by Tatsuyoshi Sugimoto.


Pesticide Biochemistry and Physiology | 1985

Inhibition of chitin biosynthesis by buprofezin analogs in relation to their activity controlling Nilaparvata lugens Stål

Yoshio Izawa; Matazaemon Uchida; Tatsuyoshi Sugimoto; Toshiro Asai

Abstract Buprofezin (Applaud, 2-tert-butylimino-3-isopropyl-5-phenyl-3,4,5,6-tetrahydro-2H-1,3,5-thiadiazin-4-one) strongly inhibited the [3H]chitin synthesis from N-acetyl- d -[1-3H]glucosamine in the brown rice planthopper, Nilaparvata lugens Stal. No inhibition was observed for [3H]-labeled protein biosynthesis from [5-3H]glucose or l -[3,5-3H]tyrosine but [3H]-labeled nucleic acid synthesis from [5-3H]glucose was weakly reduced by buprofezin. The lethal activity of buprofezin analogs related well to their inhibitory potency against chitin biosynthesis in N. lugens nymphs.


Pesticide Biochemistry and Physiology | 1987

Inhibition of prostaglandin biosynthesis and oviposition by an insect growth regulator, buprofezin, in Nilaparvata lugens Stål

Matazaemon Uchida; Yoshio Izawa; Tatsuyoshi Sugimoto

Abstract Buprofezin (2-tert-butylimino-3-isopropyl-5-phenyl-perhydro-1,3,5-thiadiazin-4-one) strongly suppressed the oviposition of Nilaparvata lugens Stal. An injection of prostaglandin E2 (10 pg/female) did not affect the egg-laying of untreated N. lugens at all, but significantly increased that of buprofezin-treated insects to produce a normal level of oviposition rate. Histological observation showed that the eggs accumulated in ovaries of the buprofezin-treated N. lugens were remarkably eliminated from the body after the prostaglandin E2 injection. [3H]Prostaglandin biosynthesis from [3H]arachidonic acid was also inhibited by 84% in the buprofezin-treated N. lugens female adults. The suppression of insect egg-laying by buprofezin should be attributed to the inhibition of prostaglandin E2 biosynthesis.


Journal of Chromatography B: Biomedical Sciences and Applications | 1985

Determination of malotilate and its metabolites in plasma and urine

Norio Takasugi; Eiichi Mafune; Shizue Yokokawa; Kazue Toriyama; Katsuo Tsuchiya; Tatsuyoshi Sugimoto

A method for the determination of malotilate (I), the corresponding monocarboxylic acid (II) and its decarboxylated product (III) in plasma is described. Plasma was extracted with chloroform spiked with internal standard. The residue, dissolved in methanol, was chromatographed on a reversed-phase column with a mobile phase of 60% acetonitrile and 1% acetic acid in water. The sensitivity limit for I, II and III was 50, 25 and 100 ng/ml of plasma, respectively. Compound I in the same plasma extract was also analysed by gas chromatography--electron-impact mass spectrometry. The base peaks m/z 160 for I and m/z 162 for internal standard (IV) were monitored; the sensitivity limit for I was 2.5 ng/ml of plasma. The determination of the metabolites of I, II and its conjugate (V), and isopropyl-hydrogen malonate (VI) in urine by high-performance liquid chromatography is also described. The limit of quantification for VI was 2.0 micrograms/ml, and the overall coefficient of variation of VI was 4.7%. The limit of quantification for II in urine was 0.5 micrograms/ml and that for V was 1.0 micrograms/ml as total II (II + V). The overall precision of the method was satisfactory. The method was used to determine plasma and urine concentrations in four dogs orally dosed with 100, 200 or 400 mg of malotilate.


Agricultural and biological chemistry | 1985

Inhibition of cuticle deposition and chitin biosynthesis by a new insect growth regulator, buprofezin, in Nilaparvata lugens Stal.

Matazaemon Uchida; Toshiro Asai; Tatsuyoshi Sugimoto


Japanese Journal of Pharmacology | 1986

Acceleration of liver regeneration by malotilate in partially hepatectomized rats

Yoshimi Niwano; Minoru Katoh; Matazaemon Uchida; Tatsuyoshi Sugimoto


Japanese Journal of Pharmacology | 1986

Activation of Mitochondrial Functions by Malotilate in Relation to Accelerated Liver Regeneration in Partially Hepatectomized Rats

Yoshimi Niwano; Shigeo Konaka; Matazaemon Uchida; Tatsuyoshi Sugimoto


Journal of Pesticide Science | 1982

Bioconcentration of Fungicidal Dialkyl Dithiolanylidenemalonates in Oryzias latipes L.

Matazaemon Uchida; Shunji Punayama; Tatsuyoshi Sugimoto


Agricultural and biological chemistry | 1986

Antagonistic Effect of 20-Hydroxy-ecdysone to an Insect Growth Regulator, Buprofezin, in Nilaparvata lugens Stal

Matazaemon Uchida; Yoshio Izawa; Tatsuyoshi Sugimoto


Journal of Pesticide Science | 1983

Metabolism of Flutolanil in Rice Plant and Cucumber

Matazaemon Uchida; Kunihiko Ogawa; Tatsuyoshi Sugimoto; Hiroyasu Aizawa


Archive | 1983

Dithiolane derivative, process for producing the same and use thereof

Hitoshi Kurono; Tatsuyoshi Sugimoto; Minoru Katoh

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