Tauhidul Islam

Speech enhancement based on student t modeling of Teager energy operated perceptual wavelet packet coefficients and a custom thresholding function

This paper presents a speech enhancement approach, where an adaptive threshold is statistically determined based on Student t Modeling of Teager energy (TE) operated perceptual wavelet packet (PWP) coefficients of noisy speech. In order to obtain an enhanced speech, the threshold thus derived is applied upon the PWP coefficients by employing a Student t pdf dependent custom thresholding function, which is designed based on a combination of modified hard and semisoft thresholding functions. Extensive simulations are carried out using the NOIZEUS database to evaluate the effectiveness of the proposed method for car and multi-talker babble noise corrupted speech signals. Several standard objective measures and subjective evaluations including formal listening tests show that the proposed method outperforms some of the state-of-the-art speech enhancement methods at high as well as low levels of SNRs.

A New Method for Estimating the Effective Poisson’s Ratio in Ultrasound Poroelastography

Ultrasound poroelastography aims at assessing the poroelastic behavior of biological tissues via estimation of the local temporal axial strains and effective Poisson’s ratios (EPR). Currently, reliable estimation of EPR using ultrasound is a challenging task due to the limited quality of lateral strain estimation. In this paper, we propose a new two-step EPR estimation technique based on dynamic programming elastography (DPE) and Horn-Schunck (HS) optical flow estimation. In the proposed method, DPE is used to estimate the integer axial and lateral displacements while HS is used to obtain subsample axial and lateral displacements from the motion-compensated pre-compressed and post-compressed radio frequency data. Axial and lateral strains are then calculated using Kalman filter-based least square estimation. The proposed two-step technique was tested using finite-element simulations, controlled experiments and in vivo experiments, and its performance was statistically compared with that of analytic minimization (AM) and correlation-based method (CM). Our results indicate that our technique provides EPR elastograms of higher quality and accuracy than those produced by AM and CM. Regarding signal-to-noise ratio and elastographic contrast-to-noise ratio, in simulated data, the proposed method provides an average improvement of 30% and 75%, respectively, with respect to AM and of 100% and 169%, respectively, with respect to CM, whereas, in experiments, the proposed approach provides an average improvement of 30% and 67% with respect to AM and of 230% and 525% with respect to CM. Based on these results, the proposed method may be the preferred one in experimental poroelastography applications.

Rayleigh modeling of teager energy operated perceptual wavelet packet coefficients for enhancing noisy speech

A statistical model for determining an adaptive threshold is proposed using Rayleigh distribution function of the teager energy (TE) operated perceptual wavelet packet coefficients.A custom thresholding function is proposed that combines ź-law and semisoft thresholding functions and is able to provide better thresholding than that provided by the thresholding functions described in the literature.Detail simulations have been carried out in order to investigate the performance of the proposed method in terms of objective and subjective senses.The performance of our proposed method is compared with state-of-the-art methods, namely Universal and SMPO.Simulation results show that the proposed method yields consistently better results in the sense of higher output segmental SNR improvement in dB, higher output PESQ, and lower WSS values than those of the existing methods. For enhancing noise corrupted speech, Rayleigh modeling of Teager energy (TE) operated perceptual wavelet packet (PWP) coefficients of the noisy speech is proposed in this paper. In order to obtain an enhanced speech, a threshold is derived and applied on the PWP coefficients by employing a custom thresholding function, which is designed based on a combination of µ-law and semisoft thresholding functions. The effectiveness of the proposed method is evaluated for car and multi-talker babble noise corrupted speech signals through performing extensive simulations using the NOIZEUS database. The proposed method is found to outperform some of the state-of-the-art speech enhancement methods not only at high but also at low levels of SNR in terms of standard objective measures and subjective evaluations including formal listening tests.

An analytical poroelastic model for ultrasound elastography imaging of tumors

The mechanical behavior of biological tissues has been studied using a number of mechanical models. Due to the relatively high fluid content and mobility, many biological tissues have been modeled as poroelastic materials. Diseases such as cancers are known to alter the poroelastic response of a tissue. Tissue poroelastic properties such as compressibility, interstitial permeability and fluid pressure also play a key role for the assessment of cancer treatments and for improved therapies. At the present time, however, a limited number of poroelastic models for soft tissues are retrievable in the literature, and the ones available are not directly applicable to tumors as they typically refer to uniform tissues. In this paper, we report the analytical poroelastic model for a non-uniform tissue under stress relaxation. Displacement, strain and fluid pressure fields in a cylindrical poroelastic sample containing a cylindrical inclusion during stress relaxation are computed. Finite element simulations are then used to validate the proposed theoretical model. Statistical analysis demonstrates that the proposed analytical model matches the finite element results with less than 0.5% error. The availability of the analytical model and solutions presented in this paper may be useful to estimate diagnostically relevant poroelastic parameters such as interstitial permeability and fluid pressure, and, in general, for a better interpretation of clinically-relevant ultrasound elastography results.

A model-based approach to investigate the effect of elevated interstitial fluid pressure on strain elastography

Finite element (FE) modeling provides a useful tool to understand the mechanical behavior of complex tissues, such as cancers, in a variety of testing conditions. Although a number of numerical and analytical models for cancerous tumors are retrievable in the literature, none of these models is capable of completely describing the behavior of a cancer embedded in a normal tissue in the conditions typical for an ultrasound elastography experiment. In this paper, we first design and implement a realistic FE model of the mechanical behavior of a cancer embedded in a normal tissue under ultrasound elastography testing conditions. In addition to the commonly used tissue mechanical properties, for the cancer, elevated interstitial fluid pressure (IFP) is incorporated in the model. IFP is a parameter of great clinical significance, but it is not typically considered in elastographic models of tumors. The developed model is then used to thoroughly study the effect of IFP on the axial, lateral and volumetric strains inside the tumor. The results of this study demonstrate that the presence of the IFP affects both the temporal and spatial distributions of the axial, lateral, volumetric strains and related elastographic parameters. Thus, these results lead to two important considerations: (1) that a correct interpretation of experimental elastographic data need a clear understanding of the effect of the IFP on the obtained elastograms and (2) that this IFP-dependent alteration of the elastographic parameters may provide an opportunity to non-invasively gain localized information about this clinically relevant parameter.

An analytical poroelastic model of a non-homogeneous medium under creep compression for ultrasound poroelastography applications - Part I

An analytical theory for the unconfined creep behavior of a cylindrical inclusion (simulating a soft tissue tumor) embedded in a cylindrical background sample (simulating normal tissue) is presented and analyzed in this paper. Both the inclusion and the background are considered as fluid-filled, porous materials, each of them being characterized by a set of mechanical properties. Specifically, in this paper, the inclusion is considered to be less permeable than the background. The cylindrical sample is compressed using a constant pressure within two frictionless plates and is allowed to expand in an unconfined way along the radial direction. Analytical expressions for the effective Poissons ratio (EPR) and fluid pressure inside and outside the inclusion are derived and analyzed. The theoretical results are validated using finite element models (FEM). Statistical analysis shows excellent agreement between the results obtained from the developed model and the results from FEM. Thus the developed theoretical model can be used in medical imaging modalities such as ultrasound poroelastography to extract the mechanical parameters of tissues and/or to better understand the impact of the different mechanical parameters on the estimated displacements, strains, stresses and fluid pressure inside a tumor and in the surrounding tissue.

A model-based approach to investigate the effect of a long bone fracture on ultrasound strain elastography

The mechanical behavior of long bones and fractures has been under investigation for many decades due to its complexity and clinical relevance. In this paper, we report a new subject-specific methodology to predict and analyze the mechanical behavior of the soft tissue at a bone interface with the intent of identifying the presence and location of bone abnormalities with high accuracy, spatial resolution, and contrast. The proposed methodology was tested on both intact and fractured rabbit femur samples with finite element-based 3-D simulations, created from actual femur computed tomography data, and ultrasound elastography experiments. The results included in this study demonstrate that elastographic strains at the bone/soft tissue interface can be used to differentiate fractured femurs from the intact ones on a distribution level. These results also demonstrate that coronal plane axial shear strain creates a unique contrast mechanism that can be used to reliably detect fractures (both complete and incomplete) in long bones. Kruskal–Wallis test further demonstrates that the contrast measure for the fracture group (simulation: 2.1286±0.2206; experiment: 2.7034 ± 1.0672) is significantly different from that for the intact group (simulation: 0 ± 0; experiment: 1.1540±0.6909) when using coronal plane axial shear strain elastography (

A novel filter for accurate estimation of fluid pressure and fluid velocity using poroelastography

p

Non-invasive imaging of Young's modulus and Poisson's ratio in cancers in vivo

< 0.01). We conclude that: 1) elastography techniques can be used to accurately identify the presence and location of fractures in a long bone and 2) the proposed model-based approach can be used to predict and analyze strains at a bone fracture site and to better interpret experimental elastographic data.

Non-invasive assessment of the spatial and temporal distributions of interstitial fluid pressure, fluid velocity and fluid flow in cancers in vivo

Fluid pressure and fluid velocity carry important information for cancer diagnosis, prognosis and treatment. Recent work has demonstrated that estimation of these parameters is theoretically possible using ultrasound poroelastography. However, accurate estimation of these parameters requires high quality axial and lateral strain estimates from noisy ultrasound radio frequency (RF) data. In this paper, we propose a filtering technique combining two efficient filters for removal of noise from strain images, i.e., Kalman and nonlinear complex diffusion filters (NCDF). Our proposed filter is based on a novel noise model, which takes into consideration both additive and amplitude modulation noise in the estimated strains. Using finite element and ultrasound simulations, we demonstrate that the proposed filtering technique can significantly improve image quality of lateral strain elastograms along with fluid pressure and velocity elastograms. Technical feasibility of the proposed method on an in vivo set of data is also demonstrated. Our results show that the CNRe of the lateral strain, fluid pressure and fluid velocity as estimated using the proposed technique is higher by at least 10.9%, 51.3% and 334.4% when compared to the results obtained using a Kalman filter only, by at least 8.9%, 27.6% and 219.5% when compared to the results obtained using a NCDF only and by at least 152.3%, 1278% and 742% when compared to the results obtained using a median filter only for all SNRs considered in this study.