Tavershima Dzenda

Effect of Yeast Probiotic on Growth, Antioxidant Enzyme Activities and Malondialdehyde Concentration of Broiler Chickens.

The aim of the study was to determine the effect of yeast probiotic on body weight, and the activities of anti-oxidant enzymes: superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), and malondialdehyde (MDA) concentration of broiler chickens. The experiment was carried out on hybrid Hubbard broiler chickens (n = 200). Two-hundred day-old chicks were randomly selected and distributed into four groups of 50 day-old chicks each: Control, C, and treatment groups comprising T1, T2 and T3 administered with 0.25 mL, 0.5 mL and 1.0 mL yeast probiotic, respectively. Chicks were fed a commercial starter diet for the first 28 days of age, followed by pelleted finisher diet from 29 to 42 days. Chickens in T1 had a significantly (p < 0.01) higher body weight at 4th week of age when compared with the control. SOD activity in all treatment groups was not significantly (p > 0.05) different when compared with the control. GPx activity was significantly (p < 0.01) higher in T1, when compared with the control. GPx activity in T2 was higher (p < 0.01) when compared with the control. There was no significant (p > 0.05) difference in MDA level in all the treatment groups. In conclusion, administering yeast probiotic supplement increased body weight and enhanced serum anti-oxidant enzyme activities of broiler chickens.

Seasonal, sex and live weight variations in feed and water consumptions of adult captive African Giant rats (Cricetomys gambianus, Waterhouse-1840) kept individually in cages.

Adult African Giant rats (Cricetomys gambianus, Waterhouse) (AGRs) (n = 231) of both sexes (117 bucks, 114 does) were live-trapped in the wild in Zaria, Nigeria. Live weight (LW), daily feed consumption (FC) and water consumption (WC) of the AGRs were measured during the cold-dry (CDS), hot-dry (HDS) and rainy (RS) seasons for 2 years with the aim of determining seasonal, sex and LW variations. Feed consumption was significantly different (p < 0.001) between all the seasons, with the lowest mean value recorded during the HDS, while the highest was obtained during the RS. Water consumption was also lowest (p < 0.001) during the HDS but did not differ significantly (p > 0.05) between the CDS and RS. Both feed and water consumptions were higher (p < 0.01) in the males (bucks) than the females (does) during the CDS and HDS, but the sex difference was not significant (p > 0.05) during the RS. Feed consumption correlated positively (p < 0.0001) with WC and relative humidity, but negatively (p < 0.0001) with LW, ambient temperature and heat index. In conclusion, both feed and water consumptions in AGRs decrease with increased seasonal heat and adult LW and are lower in does than in bucks during the dry seasons (CDS and HDS). Intervention may be indicated during the HDS to improve feed and water consumptions for optimal performance of the AGRs.

Diurnal and Seasonal Fluctuations in Rectal Temperature, Respiration and Heart Rate of Pack Donkeys in a Tropical Savannah Zone

ABSTRACT The study was designed to determine diurnal and seasonal changes in basic physiologic responses of donkeys adapted to the tropical Savannah. The rectal temperature (RT), respiratory rate (RR) and heart rate (HR) of six male Nubian pack donkeys, and the dry-bulb temperature (DBT), relative humidity and heat index of the experimental site were concurrently recorded hourly, from 06:00 h to 18:00 h (GMT +1), for three days, spread 1 week apart, during the cold-dry (harmattan), hot-dry and humid (rainy) seasons, in an open grazing field. Values of the physiologic parameters recorded during the morning (06:00 h–11:00 h) were lower (P<0.001) than those obtained in the afternoon (12:00 h–15:00 h) and evening (16:00 h–18:00 h) hours in all seasons, but the robustness of the diurnal rhythm differed (P<0.05) between seasons. Many diurnal hourly DBT mean values recorded during the harmattan and hot-dry seasons fell outside the established thermoneutral zone for tropically-adapted donkeys, while those obtained during the rainy season were within the zone, indicating that the dry seasons were more thermally stressful to the donkeys than the humid season. Overall mean RT dropped (P<0.05) during the harmattan season. The RR rose, while HR dropped (P<0.001) during the hot-dry season. In conclusion, daytime and season had profound influence on RT, RR and HR of the donkeys, therefore, diurnal and seasonal variations should be taken into account during clinical evaluation before reaching conclusion on health status and fitness for work in donkeys.

Diurnal, seasonal, and sex patterns of heart rate in grip‐restrained African giant rats (Cricetomys gambianus, Waterhouse)

This study was carried out to determine heart rate (HR) values, including diurnal, seasonal, and sex patterns, in the African giant rat (Cricetomys gambianus, Waterhouse). HR was measured using stethoscope in grip‐restrained African giant rats of either sex (103 bucks and 98 does), live‐trapped from a tropical Savannah, and caged individually in the laboratory during the harmattan (cold‐dry), hot‐dry, and rainy seasons over a 3‐year period. The HR fluctuated between 90 and 210 beats per minute (bpm) throughout the study period. Diurnal changes in HR (mean ± SEM) during the hot‐dry and rainy seasons were nonsignificant (P > 0.05), but the morning and afternoon values differed (P < 0.01) during the cold‐dry season. The HR varied (P < 0.05) among seasons, with peak, nadir, and moderate values recorded during the cold‐dry (165.8 ± 0.51 bpm), hot‐dry (153.1 ± 0.74 bpm), and rainy (163.4 ± 0.70 bpm) seasons, respectively. Mean HR of bucks was lower than that of does during the cold‐dry (P < 0.0001) and hot‐dry (P < 0.01) seasons, but sex difference during the rainy season was insignificant (P > 0.05). Overall, mean HR was lower (P < 0.0001) in bucks (158.8 ± 0.53 bpm) than in does (164.8 ± 0.53 bpm). In conclusion, values of HR in African giant rats are shown for the first time. Season, sex, and daytime influenced the HR, and should be considered during clinical evaluations of the rats.

Effect of different levels of supplemental yeast on performance indices, serum enzymes and electrolytes of broiler chickens

The aim of the study was to investigate the effect of supplemental probiotic preparation on performance indices, serum enzymes and electrolytes of broiler chickens. Two hundred (200) day-old Marshall broiler chicks were randomly selected and distributed based on the level of supplementation into four groups of 50 chicks each (Control, C; E10.5%, E21.5% and E32.0%). Chickens fed 2.0% probiotic had a significantly higher body weight when compared with the control group. Activity of alanine aminotransferase differed significantly in the group E10.5%, and especially (p<0.01) in the group E11.5%. Alkaline phosphatase activity decreased significantly (p<0.05), when compared with that of the control group. Serum calcium and phosphorus concentrations in experimental groups were significantly higher. Potassium concentration in experimental group rose significantly (p<0.05), when compared with that of the control broiler chickens. In conclusion, supplementing broiler feeds with 2.0% yeast probiotic improved performance indices, serum enzyme activities and enhanced the maintenance of electrolyte homeostasis in broiler chickens. Keywords: Body weight, feed conversion ratio, serum biochemistry, Saccharomyces cerevisiae, broiler chicken. African Journal of Biotechnology Vol. 12(35), pp. 5480-5485

Mechanism of Action of Tephrosia vogelii Leaf Extract on Isolated Rabbit Jejunum

ABSTRACT An investigation was carried out on the isolated rabbit jejunum using the crude methanolic leaf extract of Tephrosia vogelii Hook. f. (Fabaceae) with the aim of determining the possible mechanism by which it increases the contractions of intestinal smooth muscle. Atropine concentration-dependently (2.0 × 10−10–6.4 × 10−9 g/ml) blocked the effect of the extract (2.0 × 10−4–4.0 × 10−4 g/ml) on both the frequency and amplitude of contraction of the isolated tissue (n = 4). Similarly, nifedipine concentration-dependently (4.0 × 10−9–8.0 × 10−6 g/ml) blocked the effect of the extract (2.0 × 10−4–4.0 × 10−4 g/ml) on both the frequency and amplitude of contraction of the tissue (n = 4). The extract, apparently, acted through muscarinic cholinergic receptors present in the tissue, and this action probably involved the mobilization of extracellular calcium ions.

Heamatobiochemical Alterations Induced by Carbamazepine and Phenytoin: Mini Review

This review was carried out to conduct a literature survey of the effects of anticonvulsants carbamazepine (CBZ), phenytoin (PHT) and their combination on haematological and serum biochemical parameters. CBZ and PHT are among the oldest AEDs and usually the first line of treatment in epilepsy, being prescribed alone or sometimes in combination for retractable epilepsy. AEDs have been associated with different side effects which could be deleterious to the haemopoietic, nervous and/or hepatic systems. However, these effects may subside with the discontinuation of the medication(s). Side effects are prominent with the older AEDs such as CBZ, PHT, valproic acid (VPA) and phenobarbital (PB).