Taylan Oksay

Ileal orthotopic neobladder (modified Hautmann) via a shorter detubularized ileal segment: experience and results.

To evaluate the clinical, urodynamic, functional, radiological and metabolic results of the ileal (modified Hautmann) orthotopic neobladder over 10 years of experience.

Protective effects of melatonin against oxidative injury in rat testis induced by wireless (2.45 GHz) devices

Wireless devices have become part of everyday life and mostly located near reproductive organs while they are in use. The present study was designed to determine the possible protective effects of melatonin on oxidative stress–dependent testis injury induced by 2.45‐GHz electromagnetic radiation (EMR). Thirty‐two rats were equally divided into four different groups, namely cage control (A1), sham control (A2), 2.45‐GHz EMR (B) and 2.45‐GHz EMR+melatonin (C). Group B and C were exposed to 2.45‐GHz EMR during 60 min day−1 for 30 days. Lipid peroxidation levels were higher in Group B than in Group A1 and A2. Melatonin treatment prevented the increase in the lipid peroxidation induced by EMR. Also reduced glutathione (GSH) and glutathione peroxidase (GSH‐Px) levels in Group D were higher than that of exposure group. Vitamin A and E concentrations decreased in exposure group, and melatonin prevented the decrease in vitamin E levels. In conclusion, wireless (2.45 GHz) EMR caused oxidative damage in testis by increasing the levels of lipid peroxidation and decreasing in vitamin A and E levels. Melatonin supplementation prevented oxidative damage induced by EMR and also supported the antioxidant redox system in the testis.

Management of symptomatic ureteral calculi complicating pregnancy.

OBJECTIVE To review our experiences with management of symptomatic ureteral calculi complicating pregnancy. METHODS Between January 2001 and December 2011, 57 pregnant women were treated for symptomatic ureteral stones. The medical records of these patients were reviewed retrospectively. RESULTS The mean patient age was 24 (range 17-37) years and gestational age at presentation was 26 weeks (range 12-38). Most of the cases (60%) occurred in the third trimester. Flank pain was the most common presenting symptom (90%). Ultrasonography was the initial test confirming diagnosis. With conservative management, spontaneous passing of stones was noted in 13 cases (22.8%). In 10 patients (17.5%), symptomatic relief occurred without spontaneous passing of stones until the end of pregnancy. Invasive management was required in 34 patients (59.6%) because of persistent pain and/or ureteral obstruction. In 29 patients, ureteral calculi were treated successfully by ureteroscopy. Stones were extracted by pneumatic lithotripsy or forceps. In 5 patients, only double-J stent was inserted during ureteroscopy as a result of unreached or migrated stone. The majority of patients (58.8%) had lower ureteric calculi. The mean size of the stones retrieved was 7 mm (range 4-13 mm). Minor complications like ureteric edema, mild ureteric laceration, or bleeding were seen in 5 patients. Three patients had a urinary tract infection and 3 complained of stent-induced bladder irritation; uterine contraction was observed after the procedure in 1 patient, but no serious obstetric or urologic complications were observed in any case. CONCLUSION When conservative treatment fails, ureteroscopy is an effective and safe therapeutic option in symptomatic ureteral calculi complicating pregnancy.

N-acetyl cysteine attenuates diazinon exposure-induced oxidative stress in rat testis

The aim of this study was to investigate the gonadotoxic effects of diazinon and its mechanism of action with special reference to its possible reactive oxygen species generating potential in rat testis and the protective effect of N‐Acetyl Cysteine (NAC) on the exposure of diazinon. The vehicle was given orally to the control group and NAC, diazinon, combination of NAC and diazinon were given to three treatment groups for 4 weeks. Testis lipid peroxidation levels were higher in diazinon group than in control although lipid peroxidation levels were lower in diazinon + NAC group than in diazinon group. The reduced glutathione (GSH) levels were lower in diazinon group than in control and NAC group although its levels were higher in diazinon + NAC group than in diazinon group. Vitamin C, Vitamin E and β‐carotene concentrations were also lower in diazinon group than in control and NAC groups. Vitamin E and β‐carotene concentrations were higher in diazinon + NAC group than diazinon group. Glutathione peroxidase activity and vitamin A concentrations in the testis did not show any difference between the four groups. In conclusion, we observed that NAC treatment modulated diazinon‐induced oxidative injury in the rat testis. These findings suggest that NAC supplementation can be useful in testis oxidative injury caused by the organophosphate insecticides.

Effect of increasing paternal body mass index on pregnancy and live birth rates in couples undergoing intracytoplasmic sperm injection.

In this study, our purpose was to investigate the possible effect of paternal obesity on intracytoplasmic sperm injection (ICSI) outcomes on the basis of clinical pregnancy outcome. Antropometric measurements of 155 couples, referred to our infertility clinic and who underwent an ICSI cycle, have been evaluated. The study sample were divided into three groups with respect to paternal body mass index (BMI), as normal weight (BMI: 20–24.9), overweight (BMI: 25–29.9) and obese (BMI ≥ 30). Results of conventional semen analysis were also analysed. Clinical pregnancy data, including fertilisation rate, implantation rate, clinical pregnancy rate and live birth rate, were evaluated. Paternal obesity was a significant negative factor for sperm concentration and sperm motility (P = 0.03 and P = 0.01 respectively). A significant decrease of clinical pregnancy rate and live birth rate was associated with increased paternal BMI (P = 0.04 and P = 0.03 respectively). We have not determined a significant difference among groups in terms of fertilisation rate and implantation rate. This study demonstrates that increasing paternal BMI has a negative influence on ICSI success, including clinical pregnancy rate and live birth rate. There is a need for further studies to point the importance of lifestyle changes in order to overcome the negative influence of paternal obesity on couples fertility.

The effect of cadmium toxicity on renal nitric oxide synthase isoenzymes.

The aim of this study was to assess the cadmium (Cd) toxicity on renal nitric oxide synthase (NOS) isoenzymes. The study was carried out on 18 inbred male (Cd group: 10 and control group: 8) Wistar rats. Cd group received drinking water containing 15 mg/L Cd for 30 days; and at the end of the 30 days, plasma Cd was analysed. One kidney was snap frozen to assess the endothelial NOS (eNOS), inducible NOS (iNOS) and neuronal NOS (nNOS) expressions by Western blot analyses, and the other kidney was preserved for histopathological examination. Plasma Cd levels were significantly elevated in the Cd group. The Western blot analyses found higher levels of eNOS, iNOS and nNOS in the Cd group but only eNOS and nNOS levels were statistically significant. There was no difference in pathological assessment of the renal tissues. Cd toxicity increases NOS isoenzyme levels and may affect renal physiology.

Long-term effects of microsurgical varicocelectomy on pain and sperm parameters in clinical varicocele patients with scrotal pain complaints

We aimed to investigate the long‐term effects of microsurgical varicocelectomy on pain improvement and sperm parameters in patients with varicocele‐related pain. A total of 72 patients who had undergone microsurgical subinguinal varicocelectomy because of varicocele with scrotal pain between 2004 and 2009 were included in the study. The patients were grouped according to the presence or absence of pain following surgical treatment. The patients expressing a decrease in frequency and severity of pain or minimal fullness sense were included in the pain‐positive group. The mean follow‐up period was 54.4 ± 18.06 months. There was left‐sided varicocele in 80.3% of patients, while 19.7% had bilateral varicocele. In our study, complete success rate (Visual Analog Scale: 0–1) was found to be 79.2% (57/72), while failure (complete and partial failure) rate was 20.8% (15/72), and a significant difference was found (P < 0.05). Microsurgical subinguinal varicocelectomy is a reliable approach for clinically varicocele patients with scrotal pain complaints. Regardless of the type of pain, varicocelectomy significantly decreases pain. The success of the treatment is not related to the degree of varicocele.

Fragmentation of a forgotten double J stent and excreted with urine: case report.

A 45-year-old woman applied to our clinic withcomplaints of recurrent dysuria and excretionof some plastic pieces with her urine for thelast one year. When we examined the plasticpieces we recognized that they were some doubleJ fragments. The kidney ureter bladder radiography (KUB)demonstrated about 2–3 cm of stent fragments atthe left ureter, left kidney and bladder. Therewas a 3 cm of bladder opacity encircling thefragment at the bladder. The bladder stone refracted and the stentfragment was taken out. Then ureterorenoscopyperformed and the pieces at the ureter weretaken out.

Bilateral Hydronephrosis Secondary to Cystocele

Abstract A 75-year-old patient applied to the urology clinic with a cystocele and ultrasonography of urinary tract evidencing bilateral grade III hydronephrosis. She didn’t complain about any urination problem. Gynecologic examination showed a marked cystocele throughout its entire extension on the anterior wall of vagina. The excretory urography confirmed the presence of bilateral hydronephrosis and ‘narrowing distal ureters.’ An anterior colporrhaphy and tension-free vaginal tape procedure were performed without any complication. At the third month of the follow-up, regression in hydronephrosis was observed and there was no urinary complaint. In women presenting dilatation of upper urinary tract, pelvic organ prolapses must be kept in mind and a convenient examination is the key point to rule it out. Unnoticed cases can lead to a wrong diagnosis and redundant surgery.

Acute Prostatitis Due to Brucellosis; Report of Two Cases

DOI: 10.4328/JCAM.3758 Received: 14.07.2015 Accepted: 31.07.2015 Publihed Online: 02.08.2015 Corresponding Author: Ibrahim Koc, Pulmonary Medicine, Viransehir State Hospital, Sanliurfa, Turkey. GSM: +905453142502 E-Mail: Ibrahimkoc1981@gmail.com Ozet Pulmoner emboli vucudun baska bir yerinden kaynaklanan bir olusumla ile pulmoner arterlerin tikanmasi ve erken teshis ve tedavi edilmedigi takdirde yuksek olum oranina sahip bir hastaliktir. Tuberkuloz Mycobacterium tuberculosis’in neden oldugu genellikle akcigerleri etkileyen bir hastalik olup vucudun diger organlari da etkilenebilmektedir. Burada nefes darligi, kilo kaybi ve gece terlemeleri, nefes darligi sikayetleri ile klinigimize basvuran altmis uc yasinda bir kadin hasta sunulmaktadir. Ileri yasta kilo kaybi ve gece terlemesi, bir maligniteyi dusundurmus olmakla beraber tumor belirtecleri negatif saptandi. Sigara icmeyen daha onceden saglikli olan bir bireyde dusuk oksijen saturasyonu pulmoner emboliden suphelendirmistir. Akcigerin bilgisayarli tomografi anjiyografisinde lenfadenopati ve pulmoner emboli saptandi. Servikal lenf nodu eksizyonunun patolojik degerlendirmesinde kazeifikasyon nekrozu saptandi. Sonuc olarak pulmoner emboli tanili olan hastalarda kilo kaybi ve oksijen saturasyonunda dusme varsa maligniteyle beraber tuberkulozun da ekarte edilmesi gerekmektedir.