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Dive into the research topics where Teresa Nebreda is active.

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Featured researches published by Teresa Nebreda.


European Journal of Epidemiology | 2000

Epidemiological characteristics of dogs with Lyme borreliosis in the province of Soria (Spain)

Francisco Jesús Merino; J.L. Serrano; José Vicente Saz; Teresa Nebreda; María Isabel Gegúndez; María Beltrán

From the point of view of the human disease, dogs are the most important animal reservoir of Lyme borreliosis; therefore, they are used as ‘sentinel animals’. In order to know the epidemiological characteristics of dogs with antibodies against Borrelia burgdorferi, 146 canine sera samples collected during 1993–94 have been studied. The antibody detection was made by an indirect immunofluorescence method and confirmed by a haemagglutination test. Seventeen dogs (11.6%) were seropositive, of which seven were hunting dogs, three were shepherd dogs, five were domestic pets, one was a watchdog and one was a stray dog. Seven dogs had longhair phenotype, 2 medium length type, 4 hard-hair and the other 4 were short-haired. Twelve seropositive dogs were males and five were females. All seropositive dogs were more than 1 year old. The dogs with greater seroprevalence were those that harboured ticks more often than the rest. Spring and summer were the seasons when more ticks were observed. The seroprevalence found in dogs was similar to that previously obtained in humans in this area. This finding gave evidence to an intimate association between human and canine seroprevalence.


Epidemiology and Infection | 2005

Tick species and tick-borne infections identified in population from a rural area of Spain.

Francisco Jesús Merino; Teresa Nebreda; Jose Luis Serrano; Pedro Fernández-Soto; Antonio Encinas; Ricardo Pérez-Sánchez

To determine the tick species that bite humans in the province of Soria (Spain) and ascertain the tick-borne pathogens that threaten peoples health in that province, 185 tick specimens were collected from 179 patients who sought medical advice at health-care centres. The ticks were identified, and their DNA examined by PCR for pathogens. Most ticks were collected in autumn and spring (59 and 57 respectively). Nine species of ticks were identified, the most frequent being Dermacentor marginatus (55.7%), Ixodes ricinus (12.4%) and Rhipicephalus bursa (11.9%). Ninety-seven females, 66 males, 21 nymphs and one larva were identified. Twenty-six ticks carried DNA from Rickettsia spp. (11 Rickettsia slovaca, 6 Rickettsia spp. RpA4/DnS14, 1 Rickettsia massiliae/Bar29, and 8 unidentified); two ticks carried DNA from Borrelia burgdorferi sensu lato and seven ticks harboured DNA from Anaplasma phagocytophilum.


Enfermedades Infecciosas Y Microbiologia Clinica | 2001

Brote de fiebre Q y seroprevalencia en una población rural de la provincia de Soria

Teresa Nebreda; Eugenio Contreras; Francisco Jesús Merino; Eduardo Dodero; Ángel Campos

Fundamento El proposito de este estudio es describir un brote de fiebre Q aguda en una poblacion rural de Soria durante la primavera de 1998 y estudiar la prevalencia de anticuerpos IgG frente a Coxiella burnetii en dicha poblacion. MEtodos 1. Brote de fiebre Q: los datos epidemiologicos,clinicos y analiticos se obtuvieron de la historia clinica y por encuesta estandarizada de todos los casos clinicos.Estos se confirmaron por fijacion del complemento. 2. Seroprevalencia: 253 sueros fueron seleccionados por muestreo no probabilistico de conveniencia a partir de muestras de sueros extraidas entre el 1 septiembre de 1996 y el 28 de febrero de 1999. Se consideraron positivos aquellos que por inmunofluorescencia indirecta tenian titulos de anticuerpos IgG frente a C. burnetii fase II iguales o superiores a 1/80. Resultados 1. Se confirmaron 14 casos de fiebre Q con una media de edad de 21,5 ±3,1 anos. El 64% de los pacientes presentaron neumonia y el 36% unaclinica inespecifica. No se encontraron antecedentes de contacto directo con animales, pero en los alrededores del pueblo habia 4 rebanos con un total de 2.614 ovejas. 2. La seroprevalencia fue del 60% (intervalo de confianzadel 95%: 54÷66). La seroprevalencia no se incremento a raiz del brote descrito en este estudio (p > 0,05). ConclusiOn. La alta seroprevalencia de anticuerpos frente a C. burnetii en esta poblacion indica que esta area es hiperendemica para dicha infeccion y al no haberse declarado ningun caso de infeccion en los anos anteriores parece indicar que o bien cursa de forma asintomatica o los signos clinicos son extremadamente leves.Probablemente los rebanos de ovejas fueron el foco de infeccion y la via aerea el mecanismo de transmision.


Enfermedades Infecciosas Y Microbiologia Clinica | 2010

Tularemia: una década en la provincia de Soria

Carmen Aldea-Mansilla; Teresa Nebreda; Susana García-de Cruz; Eduardo Dodero; Raquel Escudero; Pedro Anda; Ángel Campos

INTRODUCTION Tularemia is a zoonotic disease that has been regularly reported in Spain since 1997. This study analyzes suspected, probable, and confirmed cases of tularemia in the province of Soria, and compares them with tularemia cases recorded in the autonomous community of Castilla y Léon, which, with the exception of 1 sporadic case, occurred in 2 epidemic outbreaks in 1997/1998 and 2007/2008. METHODS We studied all patients (53) with signs and symptoms of tularemia in the period of 1997 to 2008. Sixty-three serum samples from these patients were tested by a microagglutination assay for antibodies against Francisella tularensis; additionally 10 blood cultures and 1 culture of abscess exudate from an enlarged lymph node were carried out. RESULTS Over the last decade, 19 cases of tularemia have been diagnosed in Soria (1 sporadic case in 1996, 5 associated with an outbreak reported in 1997/98 and 13 associated with an outbreak occurring in 2007/08). In 95% of the cases, previous contact with hares was reported. The ulceroglandular type was most frequently (62%) observed. F. tularensis was isolated on blood culture in 2 cases. The remaining patients were diagnosed by serology (4 confirmed cases, 13 probable cases). CONCLUSION The cases of tularemia documented in Soria showed clinical and epidemiological features (predominant ulceroglandular clinical presentation and previous contact with hares) identical to the 1997/98 tularemia outbreak in Castilla y Léon, but contrasted with the 2007/08 outbreak in Castilla y León where typhoidal clinical forms of the disease and a relationship with an increased rodent population (Mycrotus spp) were predominant.


European Journal of Epidemiology | 1998

Most common clinical presentation of Q fever in a province in the north of Spain

Francisco Jesús Merino; Teresa Nebreda; Ángel Campos

Q fever is a world-wide zoonosis, produced by Coxiella burnetti, a microorganism belonging to the Riskettsiaceae family. Q fever can appear as a non localized feverish disease, as a feverish syndrome with hepatic impairment or as an atypic pneumonia [1, 2]. The form of presentation varies between different geografic areas, thus, feverish form is more prevalent in Australia [3], while the hepatic one is prevalent in France [4] and the pneumonic one in Nova Scotia (Canada) [5]. In order to know which is the most common presentation pattern of Q fever in our area, we have checked all cases diagnosed between 1 January, 1984 and 31 December, 1996, in the province of Soria, situated in northern Spain. A suggestive clinical feature plus antibody detection against Coxiella burnetti were used as diagnostic criteria. The techniques used for serum diagnosis were complement fixation and/or indirect immunofluorescence. Two samples of sera were obtained in all cases, one during the acute phase of the disease, another 2-4 weeks after. Those cases in which seroconversion or a 4-fold antibody titer rise were found, were considered positive. Thirteen cases of Q fever were diagnosed. Patient age at the time of diagnosis ranged from 10 to 41 years old, with a mean age of 26.72 ? 8.05. Of all the Q fever cases, eleven were men and two women. Pneumonia was the most common presentation pattern, counting 10 cases. Another three were a feverish syndrome without any focus and with an intense headache, a feverish form with hepatitis, and a chronic endocarditis. Like in other areas of northern Spain, pneumonia was the most common form of Q fever. Thus, in a group of 60 patients, 75% were pneumonia [6], in a family outbreak of 5 cases, 3 (60%) presented pneumonia [7] and of 492 Q fever cases diagnosed between 1984 and 1991, 265 (54%) had pneumonia [8]. On the other hand, in central and southern regions of Spain, relative prevalence of pneumonia went down, the hepatic form being the most frequent [9, 10]. All our cases presented as an atypical pneumonia with alveolar infiltrate, with cough in four cases and headache in three. Four patients also had chest pain and none had hemoptysis. Only in two cases, contact with animals or derived products could be found as epidemiologic data explaining how the disease was transmitted. Animals infected with C. burnetti are usually the most important source of infection. Man can be infected by aerosol inhalation, or milk or fresh contaminated cheese ingestion [1, 2, 11]. This variability in the form of clinical presentation of Q fever has been related with the presence of different strains of C. burnetti in the different geographic areas and with plasmids that would regulate the virulence of the strains [2]. It has also been postulated that different clinical patterns would be related to different ways of disease transmission. So, in those cases in which C. burnetii is transmitted by milk or dairy products ingestion, both hepatitis and pneumonia can occur, and in those cases in which the organism is acquired by air inhalation, only pneumonia would occur [12].


Journal of The European Academy of Dermatology and Venereology | 1996

Cutaneous phaeohyphomycosis due to Alternaria sp. treated successfully with itraconazole

Teresa Nebreda; Luis Javier del Pozo; Jorge Alfaro; Francisco Jesús Merino; Angel Campus; Carlos Hörndler

Combined therapy using tetracycline and nicotinamide may be more effective than tetracycline alone [8,9]. Nycomed-DAK kindly supplied the oxytetracycline and placebo tablets. Henny Bang Jakobsen of Nycomed-DAK provided valuable assistance in planning the study. Financial assistance was provided by Aalborg Stifts Julelotteri. Addendum: Due to the unusually cold weather in Denmark in the summer of 1993, we suggested to the patients that they receive oxytetracycline on an open basis during the summer of 1994. In October, 1994, 25 patients were interviewed by telephone. Fifteen of these patients were treated with 500 mg to 2 g oxytetracycline for up to several months during the hot summer of 1994. Three did not think there had been any improvement in their disease during treatment, six felt there had been moderate improvement, and six felt there had been marked improvement during the treatment period.


Journal of The European Academy of Dermatology and Venereology | 1996

Orf in a rural region of Spain

Francisco Jesús Merino; Javier Pozo; Teresa Nebreda; Carlos Hörndler; Jorge Alfaro; José Vicente Saz; Ángel Campos

tions. Pentoxifylline has been found to suppress the effector phase in these reactions [8]. In addition, PTX has anti-inflammatory effects due to various mechanisms [8-10]. These recent observations led to the trial use of PTX in ABCD during the peak season in which only systemic steroids were able to control these reactions. Pentoxifylline successfully controlled the disease and thus acted as a steroid sparing agent [10].


Enfermedades Infecciosas Y Microbiologia Clinica | 2000

Cutaneous myiasis by Sarcophaga sp

Francisco Jesús Merino; Ángel Campos; Teresa Nebreda; Cánovas C; Cuezva F


Enfermedades Infecciosas Y Microbiologia Clinica | 1999

Retrospective diagnosis of the first case of tularemia associated with hare contact in Spain

Ángel Campos; Francisco Jesús Merino; Teresa Nebreda; García-Peña Fj; Sanz-Moncasi P


Enfermedades Infecciosas Y Microbiologia Clinica | 1996

[Variation of the incidence and antibiotic sensitivity of Neisseria gonorrhoeae in a 7-year period].

Teresa Nebreda; Francisco Jesús Merino; Ángel Campos; Vázquez M

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Pedro Anda

Instituto de Salud Carlos III

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Raquel Escudero

Instituto de Salud Carlos III

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