Teruo Kutsuma

Partial hydrolysis of diethyl γγ-diethoxycarbonylpimelate: a method of preparing γγ-diethoxycarbonylpimelic acid

Abstract When one mole of diethyl γγ-diethoxycarbonylpimelate was hydrolysed with exactly two moles of sodium hydroxide in absolute ethanolic solution at room temperature, γγ-diethoxycarbonylpimelic acid was produced in excellent yield. Its structure was proved beyond doubt by two independent methods.

A practical synthesis of 8-hydroxyacyclovir and 9-(carboxymethoxymethyl)guanine, metabolites of acyclovir

Improved methods for the synthesis of 8-hydroxyacyclovir and 9-(carboxymethoxymethyl)guanine, metabolites of acyclovir, were examined. The methods were found to be useful for practical preparation of 8-hydoxyacyclovir and9-(caboxymethoxymethyl)guanine of high purity. Careful spectroscopic analysis of 8-hydroxyacyclovir in DMSO-d 6 suggested that it may be exist in an 8-oxo tautomer rather than an 8-hydroxy tautomer under the solution conditions.