Tetsuaki Kubota

Preparation of graft polypeptide binding bleomycin derivative

Abstract The esterification of carboxyl groups in poly-( l -glutamic acid) and atelo-collagen was carried out using N -hydroxysuccinimide and dicyclohexylcarbodiimide as coupling reagents in dimethylformamide (DMF) and/or dimethylsulphoxide (DMSO). The succinimide ester of polypeptide was allowed to react with the amino group of pepleomycin and then 2-aminoethanol in DMF and DMSO mixture. The graft polypeptide binding pepleomycin molecule is able to release the drug moiety during the biodegration of backbone polypeptides.

Surgical Treatment for Superior Advanced Maxillary Carcinoma and Reconstruction of the Zygomaticoorbital Floor

In cases of superior advanced maxillary carcinoma, the zygomaticoorbital floor is reconstructed using a rectus abdominis muscle flap or a osteocutaneous scapular flap after a radical maxillectomy including the zygomaticoorbital floor bone. In cases with residual disease in the zygomaticoorbital floor without an invading palatine process after radiotherapy and chemotherapy, we made an effort to keep the palatine process intact and reconstruct the zygomaticoorbital floor using a collagen plate. On the other hand, in cases with residual disease in both the zygomaticoorbital floor and palatine process, we performed a radical maxillectomy and carried out the reconstruction using an osteocutaneous scapular flap combined with a collagen plate. We performed a partial or radical maxillectomy for 8 patients with superior advanced maxillary carcinoma and reconstructed the zygomaticoorbital floor defects using a collagen plate. One was reconstructed by combining a collagen plate with an osteocutaneous scapular flap. By this method we succeeded in preventing eye ball sinking.

A Case of Olfactory Neuroblastoma

A case of olfactory neuroblastoma is reported. A 74-year-old man visited our hospital exhibiting left nasal obstruction and bleeding in May 1997. An examination revealed a large tumor in his left nasal cavity; its surface was smooth and it bled easily. The patient did not have any visual acuity difficulties and the cervical lymph nodes were not swollen. A CT scan revealed a large tumor in his left nasal cavity and maxillary sinus which did not extend into the cranial space or eye socket. There were no bone defects. The patient underwent surgery for an olfactory neuroblastoma in June 1997. Based on the pathological findings, we made a diagnosis of olfactory neuroblastoma. The patient was treated with radiation therapy after surgical therapy. 45 Gy radiation therapy was added. The patient was followed up for 1 year and 6 months. In January 1999, there was local tumor reccurence and the tumor invaded his brain. Unfortunately, he died soon after from this local recurrence of his brain tumor in June 1999.

A Case of Leukoencephalopathy after Drip Infusion of 5-Fluorouracil (5-FU)

A 42-year-old man was admitted due to advanced nasopharynx cancer and administered a total dose of 19250 mg 5-fluorouracil (5-FU). On the fifth day, he exhibited acute consciousness disturbance, and the 5-FU administration was immediately stopped. An MRI revealed a high intensity lesion on the T2weighed image. The brain disease improved gradually. We do not have an effective cure for this disease but it must be detected early.

Clinical Efficacy of Oxatomide on Japanese Cedar Pollinosis. Results of Kanagawa Multicenter Study for 3 Years.

Atsushi Shinkawa, Hirosato Miyake and Makoto Sakai (Tokai University), Isamu Takeyama (St. Marianna University School of Medicine), Tetsuya Shitara (Kitazato University), Hirokuni Otsuka and Yasuo Hattori (Nippon Medical School, Dai-ni Hospital), Yoichi Ishizuka (Teikyo University School of Medicine, Mizonokuchi Hospital), Tetsuaki Kubota (Showa University School of Medicine, Fujigaoka Hospital), Hiroyuki Zusho (Kanto Rosai Hospital)

Four cases of malignant melanoma of the beas and neck in which interferon was locally administered.

頭頸部悪性黒色腫 (MM) 4症例に対してInterferon (IFN) の局所投与を行い, 全症例にComplete Response (CR) を認めた。鼻腔症例は, DAV療法, Linac照射が奏功せず, IFN-αの局所投与のみでCRとなった。鼻中隔症例, 鼻前庭症例, 鼻背症例に対しては, 当初よりIFN-βの局所投与のみを行いCRとなった。鼻中隔症例は, 原発巣は制御されていたが, 治療後17ヵ月後に頸部リンパ節転移を認めたため頸部郭清を行い現在経過良好である。頭頸部領域におけるMMの治療上, 広範囲全摘が不可能であっても, IFNの局所投与が部位的に確実に行えるならば, IFNの位置付け役割は特記すべきものと思われた。